Hotels in Santa Clara

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Where to stay in Santa Clara?

A hotel with a swimming pool, a covered area, and a multi-story building with balconies.

A spacious lobby with a glass staircase, large arched windows, and a dragon sculpture.

A spacious lobby with high ceilings, a central seating area, and large windows offering views of the outdoors.

A resort with a large swimming pool, multiple balconies, and lush landscaping.

1. Gamboa Rainforest Reserve

Colon

$139

$152 total

includes taxes & fees

Sep 21 - Sep 22

An outdoor patio with wooden tables and beige umbrellas, surrounded by lush greenery and palm trees.

A swimming pool with a bridge, surrounded by palm trees and a building with a sloped roof.

A hotel room with two beds, a nightstand with a phone, and a wall-mounted light fixture.

A white van with floral graphics and text advertising a shuttle service to an airport.

2. Riande Aeropuerto Hotel & Casino

Tocumen

$108

$119 total

includes taxes & fees

Sep 13 - Sep 14

A swimming pool with a water feature, surrounded by plants and seating areas.

A modern reception area with a teal accent wall, a reception desk, two white chairs, and a computer monitor.

A bar area with a long counter, multiple bar stools, and a television screen displaying a sports event.

A hotel courtyard with a swimming pool, outdoor seating, and a building with multiple balconies.

3. Holiday Inn Panama Canal by IHG

Panama City

$98

$119 total

includes taxes & fees

Sep 13 - Sep 14

A pool area with a covered patio, outdoor seating, and a bar area.

A modern hotel room with a dining area, a bed, and a large window.

A modern hotel room with a bed, a desk, and a wardrobe.

A building with a covered outdoor area, multiple windows, and a fire extinguisher mounted on the wall.

4. Albrook Inn

Panama City

$68

$74 total

includes taxes & fees

Sep 25 - Sep 26

A buffet with various food items including fruits, juices, and cheeses.

A gym with treadmills, weight machines, and dumbbells.

A modern hotel lobby with a sectional sofa, a glass coffee table, and a vibrant green wall mural.

An aerial view of a rectangular swimming pool with two lounge chairs and a ladder.

5. Courtyard by Marriott Panama Metromall

San Antonio

$101

$111 total

includes taxes & fees

Oct 9 - Oct 10

A modern, well-lit buffet area with a variety of food items and neatly arranged plates.

A modern living room with a sofa, armchairs, a coffee table, and a dining area with a table and chairs.

A spacious indoor area with a high ceiling, potted plants, and a seating arrangement.

An outdoor swimming pool with lounge chairs and umbrellas, surrounded by potted plants.

6. Best Western El Dorado Panama Hotel

Bethania

$85

$93 total

includes taxes & fees

Oct 10 - Oct 11

A rooftop pool area with lounge chairs and a bar, overlooking a city skyline at sunset.

A buffet setup with various dishes and utensils.

A spacious lobby with high ceilings, large windows, and modern lighting fixtures.

A modern hotel lobby with a glass railing, seating area, and contemporary lighting fixtures.

7. Marriott Panama Hotel

Panama City

$161

$177 total

includes taxes & fees

Sep 26 - Sep 27

A hotel entrance with a central water feature, seating areas, and potted plants.

A pool with a central water feature, surrounded by seating areas and potted plants.

The entrance of The Santa Maria with a covered walkway and a view of the interior.

An outdoor dining area with wicker chairs and tables, a bar with bottles, and a pool in the background.

8. The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Juan Diaz

$269

$296 total

includes taxes & fees

Oct 1 - Oct 2

A resort with a pool area, lounge chairs, and a view of a bridge at night.

A bar area with a counter, stools, and a seating area with tables and chairs.

A formal dining area with round tables, white tablecloths, and blue lace borders.

A hotel room with a bed, a TV on a wooden cabinet, a nightstand with a lamp, and a view of the outdoors through a glass door.

9. Radisson Hotel Panama Canal

Amador

$91

$100 total

includes taxes & fees

Oct 10 - Oct 11

A poolside area with lounge chairs and a covered seating area, reflecting the pool and surrounding structures.

A spacious dining area with large windows offering a view of lush greenery.

A room with a large glass window, a wooden chair, and a glass table with a plant.

A spacious lobby with a large glass wall offering a view of the forest. There are multiple seating areas and a bar.

10. Summit Rainforest Golf Resort & All Inclusive

Panama City

$213

$235 total

includes taxes & fees

Sep 13 - Sep 14

A balcony with a view of a marina and a hilly landscape.

A modern hotel lobby with a reception desk, seating area, and a large window overlooking the city.

A couple seated on wicker chairs with a view of a body of water and greenery in the background.

A couple in white robes on a bed with a champagne bottle and ice bucket.

11. The Beach House

Amador

$77

$85 total

includes taxes & fees

Sep 11 - Sep 12

A buffet with various food items and a decorative plant.

A hotel with a swimming pool, outdoor seating, and a modern architectural design.

A spacious lobby with a high ceiling, a glass railing on the upper level, and a seating area with modern furniture.

A gym with treadmills, weight machines, and a red carpet.

12. Sheraton Grand Panama

San Francisco

$176

$193 total

includes taxes & fees

Sep 19 - Sep 20

A rooftop pool with a city view, lounge chairs, and a clear sky.

A modern lounge area with a bar, seating, and a large window offering a city view.

A modern lobby with a curved grey sofa, a round coffee table, and an orange armchair. There are potted plants and a reception desk in the background.

A modern kitchen with a marble countertop, a refrigerator, and a dining area with a table set for two.

13. Corporate Stays Arcadia | Executive Furnished Apartments

Costa del Este

$108

$125 total

includes taxes & fees

Oct 10 - Oct 11

A rooftop pool with sun loungers and a city skyline in the background.

A spacious lobby with a blue sofa, multiple armchairs, and a coffee table.

A bar area with a curved counter, multiple screens, and a patterned carpet.

A long, narrow hallway with a wooden floor and light-colored walls.

14. Waymore Hotel Spa & Casino

Bella Vista

$62

$123 total

includes taxes & fees

Sep 21 - Sep 22

A hotel with a pool, beach, and palm trees.

A large hotel with multiple towers, a central courtyard with a swimming pool, and surrounding landscaped areas.

A beachfront hotel with a large building, a beach, and a clear sky.

A spacious lobby with a large seating area, a reception desk, and large windows offering a view of the ocean and palm trees.

15. The Westin Playa Bonita Panama

Veracruz

$206

$227 total

includes taxes & fees

Sep 25 - Sep 26

A balcony with wicker chairs and a view of the cityscape.

A rooftop pool area with a view of high-rise buildings in the background.

A hotel room with a large bed, a desk with a lamp, a chair, and a view of a cityscape through a window.

A reception area with a marble wall, a 'Free Wireless Internet' sign, and a floral arrangement.

16. Ramada Plaza by Wyndham Panama Punta Pacifica

San Francisco

$72

$79 total

includes taxes & fees

Oct 2 - Oct 3

A reception area with a wooden desk, two chairs, and a plant.

A modern interior with a reception desk, seating area, and potted plants.

A balcony with a metal railing overlooking a body of water, with a clear sky in the background.

An aerial view of a marina with boats docked, a parking area, and surrounding greenery.

17. MARINN Tropical Vibes Hotel

Amador

$78

$85 total

includes taxes & fees

Sep 15 - Sep 16

A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.

A hotel room with a bed, a TV, a desk, and a view of the cityscape through a window.

A spacious lobby with a central seating area, a chandelier, and a modern ceiling design.

A modern hotel room with a dining area, a TV, and a city view.

18. Hotel Riu Plaza Panama

Bella Vista

$123

$135 total

includes taxes & fees

Sep 28 - Sep 29

A multi-story hotel with a Marriott sign, surrounded by high-rise buildings and a busy street with cars.

A modern reception area with a wooden panel wall, a sign indicating 'Marriott Bonvoy', and three reception desks with digital displays.

A coastal building complex with multiple structures, a prominent tower, and a beach in the foreground.

A modern cafe with wooden tables and chairs, large windows, and decorative vases on shelves.

19. Courtyard by Marriott Panama Multiplaza Mall

San Francisco

$110

$121 total

includes taxes & fees

Sep 26 - Sep 27

A covered outdoor seating area with a view of a city skyline and water.

A restaurant with large windows offering a view of a city skyline and palm trees.

A cityscape with high-rise buildings, a waterfront, and a modern sculpture.

A hotel room with two beds, a desk, and a large window offering a city view.

20. Plaza Paitilla Inn Hotel

San Francisco

$103

$114 total

includes taxes & fees

Oct 4 - Oct 5

View all properties

Go beyond your typical stay in Santa Clara

Pet friendly

Apartment

Apart hotel

Spa

Pool

Hot tub

Family friendly

Top landmarks in Santa Clara

Culebra Cut

8.0/10 (14 reviews)

If you're planning a bit of sightseeing during your trip, head to Culebra Cut— just one of the landmarks located 5.8 mi (9.3 km) from central Santa Clara.

See properties

Learn more about Santa Clara

The region around Santa Clara is home to attractions such as Culebra Cut and Albrook Shopping Mall.

See all hotels in Santa Clara

A beach with waves, a boat, and a forested hill in the background.

Check out reviews of Santa Clara hotels guests love

Waymore Hotel Spa & Casino

10/10 Excellent

"nice clean place and the staff was helpful"

Megapolis Hotel Panamá

10/10 Excellent

"Everything was great"

Principe Hotel and Suites

10/10 Excellent

"Superb costumer service Great Location"

Aloft by Marriott Panama

10/10 Excellent

"Everything was good"

Dreams Playa Bonita Panama - All Inclusive

8/10 Good

"Excellent stay! Dreams Playa was beautiful, relaxing, and the overall experience was wonderful. The only thing travelers should be aware of is the resort’s distance from the city. Traffic can be especially heavy between 5:00 PM and 8:00 PM, making trips from Panama City take much longer. Overall, highly recommended—just plan accordingly and be mindful of the location and traffic."

Decapolis Hotel Panama City

8/10 Good

"Decapolis hotel is in an excellent location, the breakfast buffet, the Bistro restaurant restaurant and gym are all nice. The rooms are clean and the bedding comfortable staff were friendly and helpful. However, the carpets especially on floor 19 need replacing or a deep clean. Floor 19 is also pretty loud I'm not sure what the cause is but I suspect it's the air-conditioning."

Ramada Plaza by Wyndham Panama Punta Pacifica

10/10 Excellent

"Great service, clean room 100% recommend"

Central Hotel Panama Casco Viejo

10/10 Excellent

"Very very nice, especially given that this hotel is a historic building. The food is excellent in the restaurants too. The breakfast is yummy!"

JW Marriott Panama

10/10 Excellent

"The hotel is beautiful with really nice and spacious rooms. The pool area is unbelievable. Plus, a great location."

Frequently asked questions

Can I book a refundable accommodation in Santa Clara?

If you want the flexibility to change your plans to Santa Clara, most properties offer refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Santa Clara be like during my trip?

With an average temperature of 78°F, Santa Clara is a great place if you want to enjoy the sunshine year all year long.

Why should I book my Santa Clara accommodation with Hotels.com?

There are plenty of reasons to book your Santa Clara travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.