Hotels in St. Charles

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Tonight
Oct 29 - Oct 30
Tomorrow
Oct 30 - Oct 31
This weekend
Oct 30 - Nov 1
Next weekend
Nov 6 - Nov 8

Where to stay in St. Charles?

A Comfort Inn & Suites hotel with a modern design, featuring a prominent signage and a parking lot.

1. Comfort Inn & Suites Rochester South Mayo Clinic

Comfort Inn & Suites Rochester South Mayo Clinic
2.0 star property
Rochester
8.8 out of 10, Excellent, (1,009 reviews)
Conveniently located just 0.9 mi from the airport, with a free shuttle service during limited hours. Unwind in the indoor pool and hot tub after exploring nearby Mayo Clinic. Guests love the helpful staff, clean rooms, and free amenities including breakfast, WiFi, and parking.
The price is $71
$82 total
includes taxes & fees
Nov 28 - Nov 29
Comfort Inn & Suites Rochester South Mayo Clinic
An outdoor seating area with wicker chairs and tables, surrounded by vibrant flowers and a red umbrella.

2. Stone Mill Hotel & Suites

Stone Mill Hotel & Suites
3.0 star property
Lanesboro
9.6 out of 10, Exceptional, (727 reviews)
Nestled alongside a scenic golf course, this charming hotel offers complimentary breakfast, WiFi, and parking. Outdoor enthusiasts can explore nearby hiking trails, kayaking spots, and seasonal skiing, while cultural attractions and the praised staff enhance your countryside escape.
The price is $105
$113 total
includes taxes & fees
Nov 2 - Nov 3
Stone Mill Hotel & Suites
A modern hotel lobby with a reception desk, seating area, and a kitchenette.

3. Spark by Hilton Rochester South

Spark by Hilton Rochester South
3.0 star property
Rochester
9.2 out of 10, Wonderful, (601 reviews)
Within 10 minutes of Mayo Clinic, this welcoming Rochester hotel offers free breakfast, WiFi, and parking. Swim in the indoor pool, stay fit at the on-site gym, and experience friendly service that guests consistently praise.
The price is $67
$77 total
includes taxes & fees
Nov 29 - Nov 30
Spark by Hilton Rochester South
A modern hotel lobby with a reception desk, seating area, and a dining space.

4. Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG
2.5 star property
Rochester
8.8 out of 10, Excellent, (1,002 reviews)
Relax at this Rochester hotel just minutes from Mayo Clinic. Wake up to a free hot breakfast, unwind in the indoor pool, or keep up your routine at the fitness center. Clean rooms with fridges and microwaves offer comfort after hospital visits.
The price is $92
$106 total
includes taxes & fees
Nov 27 - Nov 28
Holiday Inn Express Rochester South - Mayo Area by IHG
A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

5. Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area
2.0 star property
Rochester
9.0 out of 10, Wonderful, (1,013 reviews)
Wake up to a free full breakfast at this quiet hotel just 5 minutes from Mayo Clinic. Enjoy complimentary WiFi and parking, plus a 24-hour fitness center. The helpful staff and convenient location near Olmsted County Fairgrounds make this a peaceful choice.
The price is $67
$77 total
includes taxes & fees
Nov 28 - Nov 29
Econo Lodge Mayo Clinic Area
A two-story house with a porch and a covered entryway.

6. The Wen Inn formerly Andor Wenneson

The Wen Inn formerly Andor Wenneson
3.0 star property
Peterson
9.6 out of 10, Exceptional, (98 reviews)
This historic inn offers hiking and biking paths right outside your door, with free breakfast featuring local cuisine. Just minutes from Magelssen Bluff Park, guests enjoy complimentary WiFi, parking, and peaceful garden views.
The price is $105
$114 total
includes taxes & fees
Nov 4 - Nov 5
The Wen Inn formerly Andor Wenneson
A hotel lobby with a reception desk, seating area, and a bar.

7. Super 8 by Wyndham Rochester Mayo Clinic Area

Super 8 by Wyndham Rochester Mayo Clinic Area
2.0 star property
Rochester
7.8 out of 10, Good, (1,000 reviews)
Tranquil accommodations just 5 minutes from Mayo Clinic with complimentary on-the-go breakfast served each morning. Guests consistently praise the helpful staff and quiet atmosphere. Apache Mall and Olmsted County Fairgrounds are located nearby.
The price is $51
$59 total
includes taxes & fees
Nov 7 - Nov 8
Super 8 by Wyndham Rochester Mayo Clinic Area
A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

8. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3.0 star property
Rochester
7.6 out of 10, Good, (1,059 reviews)
Situated just a 10-minute drive from Mayo Clinic, this hotel offers a complimentary buffet breakfast each morning. Guests appreciate the spotless rooms, free WiFi, and parking. The fitness center and proximity to local attractions add extra value.
The price is $71
$82 total
includes taxes & fees
Nov 15 - Nov 16
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

9. Quality Inn & Suites Mayo Clinic Area

Quality Inn & Suites Mayo Clinic Area
2.5 star property
Rochester
8.8 out of 10, Excellent, (969 reviews)
This hotel offers peaceful rooms just 5 minutes from Mayo Clinic, with complimentary full breakfast and parking. Nearby restaurants and shops enhance convenience, while attentive staff ensure a comfortable stay near Olmsted County Fairgrounds.
The price is $67
$78 total
includes taxes & fees
Nov 27 - Nov 28
Quality Inn & Suites Mayo Clinic Area
A multi-story building with a balcony, surrounded by various potted plants and flowers.

10. Green Gables Inn

Green Gables Inn
2.0 star property
Lanesboro
9.6 out of 10, Exceptional, (172 reviews)
Nestled in Lanesboro with free continental breakfast served each morning, this welcoming inn offers complimentary WiFi and parking. Discover nearby Root River and Sylvan Park during your stay, with convenient access for outdoor adventures.
The price is $147
$158 total
includes taxes & fees
Oct 30 - Oct 31
Green Gables Inn
A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.

11. AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic
3.0 star property
Rochester
8.2 out of 10, Very good, (1,582 reviews)
Steps from Mayo Clinic, this tranquil hotel offers an indoor pool and on-site dining at Crooked Pint Ale House. Rooms include microwaves and refrigerators while the quiet environment ensures restful recovery. Free breakfast and parking add convenience.
The price is $75
$87 total
includes taxes & fees
Nov 8 - Nov 9
AmericInn by Wyndham Rochester Near Mayo Clinic
A hotel room with two beds, a desk, a chair, a TV, a wardrobe, and a window with curtains.

12. MainStay Suites Rochester South Mayo Clinic

MainStay Suites Rochester South Mayo Clinic
2.5 star property
Rochester
7.4 out of 10, Good, (146 reviews)
This extended-stay hotel offers free WiFi and parking only 10 minutes from Mayo Clinic. Spacious suites provide a home base while you're near major medical facilities, with Marcus Rochester Cinema and Olmsted County Fairgrounds close by.
The price is $61
$70 total
includes taxes & fees
Nov 8 - Nov 9
MainStay Suites Rochester South Mayo Clinic
A reception area with a stone wall, a marble counter, and a red accent wall.

13. Red Carpet Inn Rochester

Red Carpet Inn Rochester
2.0 star property
Rochester
7.6 out of 10, Good, (562 reviews)
The price is $63
$73 total
includes taxes & fees
Oct 30 - Oct 31
Red Carpet Inn Rochester
Interior detail

14. Birch Hill Suite Rochester – Med City

Birch Hill Suite Rochester – Med City
2.5 star property
Rochester
7.6 out of 10, Good, (97 reviews)
This modern Rochester hotel offers free WiFi and parking, plus a fitness center for health-conscious guests. Located within 10 minutes of Mayo Clinic and Saint Marys Campus, it's also near Marcus Cinema and Olmsted County Fairgrounds.
The price is $64
$74 total
includes taxes & fees
Nov 1 - Nov 2
Birch Hill Suite Rochester – Med City
A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

15. Hampton Inn Rochester-South

Hampton Inn Rochester-South
2.5 star property
Rochester
9.0 out of 10, Wonderful, (1,000 reviews)
Unwind in this tranquil retreat just 5 minutes from Mayo Clinic. After enjoying the free breakfast, take a refreshing dip in the indoor pool or relax in the hot tub. The helpful staff, free WiFi, and convenient parking enhance your stay near Apache Mall.
The price is $98
$113 total
includes taxes & fees
Nov 8 - Nov 9
Hampton Inn Rochester-South
A hotel room with a large bed, a desk with a chair, a television, and a view of the outdoors through a door.

16. Baymont by Wyndham Rochester Mayo Clinic Area

Baymont by Wyndham Rochester Mayo Clinic Area
2.5 star property
Rochester
7.0 out of 10, Good, (845 reviews)
The price is $60
$69 total
includes taxes & fees
Nov 22 - Nov 23
Baymont by Wyndham Rochester Mayo Clinic Area
A Comfort Inn hotel with a stone facade, a covered entrance, and a parking area.

17. Comfort Inn & Suites West - Medical Center

Comfort Inn & Suites West - Medical Center
3.0 star property
Rochester
8.8 out of 10, Excellent, (666 reviews)
Conveniently located just 10 minutes from Mayo Clinic, this Rochester hotel offers comfort with an indoor pool and relaxing hot tub. Free parking and a fitness center enhance your stay while medical facilities remain easily accessible.
The price is $87
$100 total
includes taxes & fees
Nov 28 - Nov 29
Comfort Inn & Suites West - Medical Center
An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

18. Home2 Suites by Hilton Rochester Mayo Clinic Area

Home2 Suites by Hilton Rochester Mayo Clinic Area
3.0 star property
Rochester
9.6 out of 10, Exceptional, (1,000 reviews)
Relax at this Rochester hotel just 5 minutes from Mayo Clinic. Splash in 2 indoor pools or work out at the fitness center. The comfortable rooms include sofa beds and refrigerators, while free breakfast, WiFi, and parking add value to your stay.
The price is $110
$126 total
includes taxes & fees
Nov 7 - Nov 8
Home2 Suites by Hilton Rochester Mayo Clinic Area
A hotel room with two beds, a large landscape painting above the headboard, a bedside table with a phone, and a blue patterned rug.

19. Days Inn by Wyndham Winona

Days Inn by Wyndham Winona
2.0 star property
Winona
7.6 out of 10, Good, (1,000 reviews)
Wake up to free breakfast at this business-friendly Winona hotel, where a 24-hour fitness center keeps you energized. Just minutes from Remlinger Muscle Cars, enjoy clean rooms, helpful staff, and convenient parking near Mississippi River attractions.
The price is $67
$75 total
includes taxes & fees
Nov 19 - Nov 20
Days Inn by Wyndham Winona
A spacious outdoor dining area with multiple tables and chairs, large windows, and a wooden ceiling structure.

20. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (1,000 reviews)
Steps from Rochester Public Library and Shops University Square, this hotel offers peaceful rooms and a rooftop terrace. Enjoy American cuisine at Crave restaurant, grab snacks at the deli, or unwind at the bar after using the fitness center.
The price is $93
$107 total
includes taxes & fees
Nov 28 - Nov 29
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Go beyond your typical stay in St. Charles

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Learn more about St. Charles

St. Charles is well-known for its attractions such as Whitewater State Park and Whitewater River.

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An aerial view of a town with industrial buildings, roads, and green areas.

Check out reviews of St. Charles hotels guests love

A multi-story building with a balcony, surrounded by various potted plants and flowers.
Green Gables Inn

Green Gables Inn

Green Gables Inn
Lanesboro

10/10 Exceptional

Quiet, accessible, very clean. Enjoyed how close it is to downtown.
United States
RICHARD
Reviewed June 6, 2025
Green Gables Inn

Frequently Asked Questions

What accommodations do travelers recommend in St. Charles?

White Valley Motel is an accommodation that is popular with guests.

Can I book refundable accommodations in St. Charles?

If you need the flexibility to change your plans to St. Charles, most properties provide refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in St. Charles be like during my vacation?

July and August are typically the warmest months in St. Charles when the average temp is 67°F. January and February are the coldest months when the average temperature is 22°F. June and May are the months with the most rain.

Why should I book my St. Charles accommodation with Hotels.com?

There are plenty of reasons to book your St. Charles travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.