Hotels in Florida Keys Scenic Highway
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Amoray Dive Resort
Amoray Dive Resort
2.0 star property
Key Largo
9.2 out of 10, Wonderful, (1001)
9.2/10
Wonderful
(1001)
- Coastal paradise near pristine John Pennekamp State Park awaits water enthusiasts.
The price is $157
$157
$204 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Reefhouse Resort & Marina
Reefhouse Resort & Marina
3.5 star property
Key Largo
9.2 out of 10, Wonderful, (1330)
9.2/10
Wonderful
(1330)
- Unwind by a private beach minutes from John Pennekamp Coral Reef State Park.
The price is $229
$229
$298 total
includes taxes & fees
Dec 21 - Dec 22
Azul del Mar
Azul del Mar
3.5 star property
Key Largo
9.0 out of 10, Wonderful, (799)
9.0/10
Wonderful
(799)
The price is $219
$219
$246 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Hampton Inn Key Largo Manatee Bay
Hampton Inn Key Largo Manatee Bay
2.5 star property
Key Largo
8.8 out of 10, Excellent, (1005)
8.8/10
Excellent
(1005)
- Seaside escape with a private beach and pool, minutes from Coral Reef State Park.
The price is $179
$179
$201 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Largo Resort
Largo Resort
3.0 star property
Key Largo
9.4 out of 10, Exceptional, (294)
9.4/10
Exceptional
(294)
- Palm-lined paradise minutes from the coral reef state park for a serene escape.
The price is $238
$238
$334 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Dolphin Point Villas
Dolphin Point Villas
3.5 star property
Key Largo
9.6 out of 10, Exceptional, (469)
9.6/10
Exceptional
(469)
- Beachfront escape with a private shore and nearby coral reef adventures.
The price is $219
$219
$275 total
includes taxes & fees
Dec 21 - Dec 22
Sunset Cove Beach Resort
Sunset Cove Beach Resort
2.5 star property
Key Largo
9.0 out of 10, Wonderful, (1001)
9.0/10
Wonderful
(1001)
The price is $221
$221
$249 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The Pelican Key Largo Cottages
The Pelican Key Largo Cottages
2.0 star property
Key Largo
8.8 out of 10, Excellent, (1001)
8.8/10
Excellent
(1001)
- Coastal cottages with private marina and water adventures minutes from Key Largo's attractions.
The price is $122
$122
$137 total
includes taxes & fees
Dec 22 - Dec 23
Playa Largo Resort & Spa, Autograph Collection
Playa Largo Resort & Spa, Autograph Collection
4.5 star property
Rock Harbor
8.8 out of 10, Excellent, (1000)
8.8/10
Excellent
(1000)
- Beachside elegance on Key Largo with cabanas and marina access, plus 3 restaurants.
The price is $343
$343
$441 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Coconut Bay Resort Key Largo
Coconut Bay Resort Key Largo
2.0 star property
Rock Harbor
9.6 out of 10, Exceptional, (192)
9.6/10
Exceptional
(192)
- Experience the Florida Keys waterfront while just minutes from coral reefs.
The price is $235
$235
$264 total
includes taxes & fees
Dec 20 - Dec 21
Chesapeake Beach Resort
Chesapeake Beach Resort
3.5 star property
Matecumbe
9.2 out of 10, Wonderful, (1599)
9.2/10
Wonderful
(1599)
- Escape to a peaceful ocean retreat with breathtaking sunset views in Islamorada.
The price is $189
$189
$269 total
includes taxes & fees
Dec 22 - Dec 23
Drop Anchor
Drop Anchor
3.0 star property
Islamorada
8.8 out of 10, Excellent, (1000)
8.8/10
Excellent
(1000)
- Unwind at this oceanfront Art Deco gem with free kayaking and bicycles.
The price is $149
$149
$202 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Cheeca Lodge & Spa
Cheeca Lodge & Spa
5.0 star property
Matecumbe
9.2 out of 10, Wonderful, (1272)
9.2/10
Wonderful
(1272)
The price is $499
$499
$635 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Breezy Palms Resort
Breezy Palms Resort
2.5 star property
Matecumbe
8.8 out of 10, Excellent, (588)
8.8/10
Excellent
(588)
- Coastal hideaway with marina access just steps from Breezy Palms Beach.
The price is $125
$125
$193 total
includes taxes & fees
Dec 21 - Dec 22
Bayside Villas by Islander Resort
Bayside Villas by Islander Resort
3.5 star property
Matecumbe
8.8 out of 10, Excellent, (401)
8.8/10
Excellent
(401)
The price is $349
$349
$460 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Lime Tree Bay Resort
Lime Tree Bay Resort
3.5 star property
Long Key
9.2 out of 10, Wonderful, (1105)
9.2/10
Wonderful
(1105)
- Beachfront escape with tennis, kayaking, and multiple pools along Florida's scenic Keys.
The price is $159
$159
$224 total
includes taxes & fees
Dec 23 - Dec 24
Edgewater Lodge
Edgewater Lodge
2.5 star property
Long Key
8.6 out of 10, Excellent, (800)
8.6/10
Excellent
(800)
- Oceanfront retreat with marina access and kayaking in Long Key, Florida.
The price is $249
$249
$280 total
includes taxes & fees
Dec 20 - Dec 21
Rainbow Bend Resort
Rainbow Bend Resort
2.5 star property
Marathon
8.2 out of 10, Very Good, (784)
8.2/10
Very Good
(784)
- Enjoy the private Florida Keys beach and pool at an oceanfront hideaway in Marathon.
The price is $109
$109
$168 total
includes taxes & fees
Dec 21 - Dec 22
Kingsail Resort
Kingsail Resort
2.0 star property
Marathon
8.6 out of 10, Excellent, (1042)
8.6/10
Excellent
(1042)
- Serene waterfront motel with marina access and a short drive to Sombrero Beach.
The price is $135
$135
$152 total
includes taxes & fees
Dec 21 - Dec 22
Ibis Bay Beach Resort
Ibis Bay Beach Resort
2.5 star property
Northside Resort
8.0 out of 10, Very Good, (2012)
8.0/10
Very Good
(2012)
The price is $156
$156
$202 total
includes taxes & fees
Dec 20 - Dec 21
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Great weekend hotel deals in Florida Keys Scenic Highway, FL
Showing deals for:Dec 26 - Dec 28
Image gallery for Playa Largo Resort & Spa, Autograph Collection
Playa Largo Resort & Spa, Autograph Collection
4.5 star property
Key Largo
8.8/10Excellent (1,000 reviews)
14% off
$807 nightly
Price is $1,925
$1,925
Total with taxes and fees
Total with taxes and fees
Image gallery for Almond Tree Inn Hotel - Adults Only
VIP Access
Almond Tree Inn Hotel - Adults Only
3.5 star property
Key West
10/10Exceptional (1,000 reviews)
30% off
$798 nightly
Price is $1,795
$1,795
Total with taxes and fees
Total with taxes and fees
Image gallery for Chesapeake Beach Resort
Chesapeake Beach Resort
3.5 star property
Islamorada
9.2/10Wonderful (1,599 reviews)
5% off
$769 nightly
Price is $1,842
$1,842
Total with taxes and fees
Total with taxes and fees
Image gallery for Lime Tree Bay Resort
VIP Access
Lime Tree Bay Resort
3.5 star property
Long Key
9.2/10Wonderful (1,105 reviews)
Member Price available
$579 nightly
Price is $1,393
$1,393
Total with taxes and fees
Total with taxes and fees
Image gallery for Ibis Bay Beach Resort
Ibis Bay Beach Resort
2.5 star property
Key West
8.0/10Very Good (2,012 reviews)
Member Price available
$587 nightly
Price is $1,376
$1,376
Total with taxes and fees
Total with taxes and fees
Image gallery for Rainbow Bend Resort
Rainbow Bend Resort
2.5 star property
Marathon
8.2/10Very Good (784 reviews)
5% off
$455 nightly
Price is $1,114
$1,114
Total with taxes and fees
Total with taxes and fees
Image gallery for The Pelican Key Largo Cottages
The Pelican Key Largo Cottages
2.0 star property
Key Largo
8.8/10Excellent (1,001 reviews)
Member Price available
$455 nightly
Price is $1,023
$1,023
Total with taxes and fees
Total with taxes and fees
Check out pet-friendly hotels in Florida Keys Scenic Highway
9.2 out of 10, Wonderful, (1330)
9.2/10
Wonderful
(1330)
The price is $229
$229
$298 total
includes taxes & fees
Dec 21 - Dec 22
8.8 out of 10, Excellent, (1005)
8.8/10
Excellent
(1005)
The price is $179
$179
$201 total
includes taxes & fees
Jan 6 - Jan 7, 2026
9.0 out of 10, Wonderful, (1001)
9.0/10
Wonderful
(1001)
The price is $221
$221
$249 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Playa Largo Resort & Spa, Autograph Collection
Playa Largo Resort & Spa, Autograph Collection4.5 star property
Rock Harbor
8.8 out of 10, Excellent, (1000)
8.8/10
Excellent
(1000)
The price is $343
$343
$441 total
includes taxes & fees
Jan 19 - Jan 20, 2026
8.8 out of 10, Excellent, (1000)
8.8/10
Excellent
(1000)
The price is $149
$149
$202 total
includes taxes & fees
Jan 11 - Jan 12, 2026
9.2 out of 10, Wonderful, (1599)
9.2/10
Wonderful
(1599)
The price is $189
$189
$269 total
includes taxes & fees
Dec 22 - Dec 23
8.8 out of 10, Excellent, (392)
8.8/10
Excellent
(392)
The price is $185
$185
$222 total
includes taxes & fees
Jan 5 - Jan 6, 2026
9.2 out of 10, Wonderful, (1105)
9.2/10
Wonderful
(1105)
The price is $159
$159
$224 total
includes taxes & fees
Dec 23 - Dec 24
8.6 out of 10, Excellent, (800)
8.6/10
Excellent
(800)
The price is $249
$249
$280 total
includes taxes & fees
Dec 20 - Dec 21
8.2 out of 10, Very Good, (784)
8.2/10
Very Good
(784)
The price is $109
$109
$168 total
includes taxes & fees
Dec 21 - Dec 22
You may also like hotels with pools in Florida Keys Scenic Highway
9.2 out of 10, Wonderful, (1001)
9.2/10
Wonderful
(1001)
The price is $157
$157
$204 total
includes taxes & fees
Jan 6 - Jan 7, 2026
9.2 out of 10, Wonderful, (1330)
9.2/10
Wonderful
(1330)
The price is $229
$229
$298 total
includes taxes & fees
Dec 21 - Dec 22
8.8 out of 10, Excellent, (1005)
8.8/10
Excellent
(1005)
The price is $179
$179
$201 total
includes taxes & fees
Jan 6 - Jan 7, 2026
9.4 out of 10, Exceptional, (294)
9.4/10
Exceptional
(294)
The price is $238
$238
$334 total
includes taxes & fees
Jan 18 - Jan 19, 2026
9.6 out of 10, Exceptional, (469)
9.6/10
Exceptional
(469)
The price is $219
$219
$275 total
includes taxes & fees
Dec 21 - Dec 22
Playa Largo Resort & Spa, Autograph Collection
Playa Largo Resort & Spa, Autograph Collection4.5 star property
Rock Harbor
8.8 out of 10, Excellent, (1000)
8.8/10
Excellent
(1000)
The price is $343
$343
$441 total
includes taxes & fees
Jan 19 - Jan 20, 2026
8.8 out of 10, Excellent, (1000)
8.8/10
Excellent
(1000)
The price is $149
$149
$202 total
includes taxes & fees
Jan 11 - Jan 12, 2026
9.2 out of 10, Wonderful, (1599)
9.2/10
Wonderful
(1599)
The price is $189
$189
$269 total
includes taxes & fees
Dec 22 - Dec 23
8.8 out of 10, Excellent, (588)
8.8/10
Excellent
(588)
The price is $125
$125
$193 total
includes taxes & fees
Dec 21 - Dec 22
8.8 out of 10, Excellent, (392)
8.8/10
Excellent
(392)
The price is $185
$185
$222 total
includes taxes & fees
Jan 5 - Jan 6, 2026
You can also stay at hotels with an ocean view in Florida Keys Scenic Highway
9.0 out of 10, Wonderful, (799)
9.0/10
Wonderful
(799)
The price is $219
$219
$246 total
includes taxes & fees
Jan 5 - Jan 6, 2026
9.2 out of 10, Wonderful, (1001)
9.2/10
Wonderful
(1001)
The price is $157
$157
$204 total
includes taxes & fees
Jan 6 - Jan 7, 2026
9.4 out of 10, Exceptional, (294)
9.4/10
Exceptional
(294)
The price is $238
$238
$334 total
includes taxes & fees
Jan 18 - Jan 19, 2026
8.8 out of 10, Excellent, (1000)
8.8/10
Excellent
(1000)
The price is $149
$149
$202 total
includes taxes & fees
Jan 11 - Jan 12, 2026
9.2 out of 10, Wonderful, (1599)
9.2/10
Wonderful
(1599)
The price is $189
$189
$269 total
includes taxes & fees
Dec 22 - Dec 23
9.2 out of 10, Wonderful, (1272)
9.2/10
Wonderful
(1272)
The price is $499
$499
$635 total
includes taxes & fees
Jan 3 - Jan 4, 2026
8.8 out of 10, Excellent, (588)
8.8/10
Excellent
(588)
The price is $125
$125
$193 total
includes taxes & fees
Dec 21 - Dec 22
9.2 out of 10, Wonderful, (1105)
9.2/10
Wonderful
(1105)
The price is $159
$159
$224 total
includes taxes & fees
Dec 23 - Dec 24
8.6 out of 10, Excellent, (800)
8.6/10
Excellent
(800)
The price is $249
$249
$280 total
includes taxes & fees
Dec 20 - Dec 21
8.2 out of 10, Very Good, (784)
8.2/10
Very Good
(784)
The price is $109
$109
$168 total
includes taxes & fees
Dec 21 - Dec 22
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Florida Keys Scenic Highway
Apart hotel
Ocean view
Pet friendly
Family friendly
Resort
Learn more about Florida Keys Scenic Highway
Florida Keys Scenic Highway is well-known for its attractions such as Duval Street and Curry Hammock State Park.
Check out reviews of Florida Keys Scenic Highway hotels guests love
Blue Flamingo Resort Key West
10/10 Excellent
"This is the excellent hotel. The best most impressive hotel stay I have ever been to. It’s top clean. Wifi is super fast. Lots of charging outlet. Bath is super clean and shining. Resort has a lot of fun. "
Cheeca Lodge & Spa
10/10 Excellent
"Ate dinner at the Asian restaurant Nikki- the Chilean Seabass was delicious andmelted with every bite.
And service was good"
DoubleTree Resort by Hilton Grand Key - Key West
10/10 Excellent
"The room was clean and comfortable. Pool area was fabulous! Staff was friendly and helpful too"
Ibis Bay Beach Resort
10/10 Excellent
"Very goood "
Beachside Resort & Residences
10/10 Excellent
"Great spacious room! Very comfortable"
Lime Tree Bay Resort
10/10 Excellent
"Just the best!"
Southernmost Beach Resort and Guesthouses
10/10 Excellent
"Comfortable bed, nice amenities enjoyed live music in the afternoon by the pool. "
Travelodge by Wyndham Florida City/Homestead/Everglades
10/10 Excellent
"The staff members was very friendly, very clean rooms and very close to everything definitely going back to this hotel"
Hyatt Vacation Club at Windward Pointe, Key West
10/10 Excellent
"Excellent place to stay on Key West, spacious apartment, nice view, quiet area, great pool area and billiard table, mini market inside property. Just 10 min drive to famous Duvall Street and different restaurants walking distance from the hotel."
Frequently asked questions
Why should I book my Florida Keys Scenic Highway accommodation with Hotels.com?
There are plenty of reasons to book your Florida Keys Scenic Highway travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.