Top 10 Hotels in Adrian, TX in 2026 (from $76)

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Where to stay in Adrian?

A Country Inn with a red and white color scheme, a reception desk, a coffee bar, and a large window with blinds.

A hotel bathroom with a sink, a coffee maker, a hair dryer, and a mirror.

A hotel room with a bed, bedside tables, a desk, a chair, a television, and a bathroom visible in the background.

A modern living room with a red accent wall, a white reception desk, and a large clock.

1. Route 66 Desert Rose Country Inn

Vega

$76

$86 total

includes taxes & fees

Sep 16 - Sep 17

A swimming pool with white chairs around it, a tiled border, and a window with a view.

A hotel room with two beds, a desk, a chair, a television, and a painting on the wall.

A bathroom with a white bathtub, a shower with a handheld showerhead, a metal shelf with towels, and a step stool.

A modern building with a flat roof, large windows, and a covered entrance area.

2. Days Inn by Wyndham Vega TX

Vega

$86

$96 total

includes taxes & fees

Sep 20 - Sep 21

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Go beyond your typical stay in Adrian

Top landmarks in Adrian

Midway Point of Route 66

You might want to get your camera out and head to Midway Point of Route 66— just one of the landmarks located 0.5 mi (0.8 km) from central Adrian.

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Learn more about Adrian

The region around Adrian is home to attractions such as Midway Point of Route 66 and Magnolia Gas Station.

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Frequently Asked Questions

Can I book refundable hotels in Adrian?

If you want the flexibility to change your travel plans to Adrian, most hotels provide refundable* rates you can book. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in Adrian be like during my trip?

The warmest months in Adrian are usually July and August with an average temp of 78°F. January and December are the chilliest months when the average temp is 43°F. The rainiest months are May and October.

Why should I book my Adrian hotel through Hotels.com?

There are plenty of reasons to book your Adrian travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.