Hotels in Byron

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Top 5 hotels in Byron at a glance

Comfort Inn & Suites West - Medical Center — 3-star hotel in Rochester. Guest rating: 8.8/10 — Excellent.
Sleep Inn & Suites West-Near Medical Center — 2.5-star hotel in Rochester. Guest rating: 9.0/10 — Wonderful.
Hampton Inn & Suites Rochester-North — 2.5-star hotel in Rochester. Guest rating: 9.2/10 — Wonderful.
Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG — 2.5-star hotel in Kutzky Park. Guest rating: 8.6/10 — Excellent.
Staybridge Suites Rochester - Commerce Dr NW by IHG — 3-star hotel in Rochester. Guest rating: 8.8/10 — Excellent.

Where to stay in Byron?

Comfort Inn & Suites West - Medical Center

Rochester

$87

$100 total

includes taxes & fees

Sep 5 - Sep 6

Efficiency Two Queen Suite with Sofa Bed - Disabled Access - Non-Smoking | Premium bedding, desk, blackout drapes, iron/ironing board

Sleep Inn & Suites West-Near Medical Center

Rochester

$86

$99 total

includes taxes & fees

Sep 13 - Sep 14

Indoor pool, open 6 AM to midnight, sun loungers

Two queens bed non smoking | Premium bedding, in-room safe, laptop workspace, blackout drapes

Hampton Inn & Suites Rochester-North

Rochester

$98

$112 total

includes taxes & fees

Aug 30 - Aug 31

Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Kutzky Park

$95

$109 total

includes taxes & fees

Aug 22 - Aug 23

Studio Suite, 1 Queen Bed, Kitchen | In-room safe, desk, laptop workspace, iron/ironing board

Staybridge Suites Rochester - Commerce Dr NW by IHG

Rochester

$127

$146 total

includes taxes & fees

Aug 22 - Aug 23

Suite, 1 King Bed, Non Smoking | Desk, laptop workspace, iron/ironing board, bed sheets

Quality Inn near Medical Center

Rochester

$63

$72 total

includes taxes & fees

Sep 6 - Sep 7

Suite, 1 King Bed, Non Smoking | 1 bedroom, premium bedding, pillowtop beds, desk

Baymont by Wyndham Kasson Rochester Area

Kasson

$60

$64 total

includes taxes & fees

Sep 6 - Sep 7

Indoor pool, open 9:00 AM to 10:00 PM, pool umbrellas, sun loungers

Executive Room, 2 Queen Beds, Refrigerator & Microwave, Pool View (Living Room) | Blackout drapes, soundproofing, iron/ironing board

Executive Room, 2 Queen Beds, Non Smoking, Refrigerator & Microwave (Living Room) | Blackout drapes, soundproofing, iron/ironing board

Standard Room, 2 Queen Beds, Accessible, Refrigerator & Microwave | Blackout drapes, soundproofing, iron/ironing board

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Rochester

$94

$108 total

includes taxes & fees

Aug 23 - Aug 24

In-room safe, desk, iron/ironing board, cribs (free)

Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

Rochester

$70

$80 total

includes taxes & fees

Sep 1 - Sep 2

Studio, 2 Double Beds, Non Smoking | Desk, iron/ironing board, WiFi (free), bed sheets

Studio, 1 King Bed, Non Smoking | Private kitchen | Coffee/tea maker, full-size fridge, microwave, stovetop

Extended Stay America Suites Rochester North

Rochester

$68

$79 total

includes taxes & fees

Aug 29 - Aug 30

Premium bedding, desk, blackout drapes, iron/ironing board

TownePlace Suites by Marriott Rochester

Rochester

$98

$113 total

includes taxes & fees

Aug 23 - Aug 24

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Rochester

$76

$87 total

includes taxes & fees

Aug 23 - Aug 24

In-room safe, laptop workspace, blackout drapes, iron/ironing board

Hampton Inn Rochester-South

Rochester

$93

$108 total

includes taxes & fees

Aug 28 - Aug 29

Suite, 1 King Bed, Jetted Tub | In-room safe, desk, laptop workspace, iron/ironing board

Holiday Inn Express Rochester South - Mayo Area by IHG

Rochester

$92

$106 total

includes taxes & fees

Aug 21 - Aug 22

Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park

$112

$128 total

includes taxes & fees

Sep 3 - Sep 4

Desk, blackout drapes, iron/ironing board, cribs (free)

Standard Room, 1 King Bed, Non Smoking | Desk, blackout drapes, iron/ironing board, cribs (free)

Indoor pool, open 7:00 AM to 11:00 PM, sun loungers

Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

$77

$89 total

includes taxes & fees

Aug 23 - Aug 24

Apartment, 1 King Bed, Accessible, Non Smoking (Mobility/Hearing, Tub w/Grab bars) | Premium bedding, down comforters, pillowtop beds, desk

Apartment, 1 Bedroom, 2 Queen Beds, Non Smoking | Premium bedding, down comforters, pillowtop beds, desk

AmericInn by Wyndham Rochester Near Mayo Clinic

Rochester

$75

$87 total

includes taxes & fees

Aug 23 - Aug 24

Desk, laptop workspace, blackout drapes, iron/ironing board

Suite, 1 Bedroom | Living room | Flat-screen TV, Netflix

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Kutzky Park

$104

$119 total

includes taxes & fees

Sep 12 - Sep 13

Standard Room, 1 King Bed, Non Smoking | Desk, WiFi (free), bed sheets

Econo Lodge Mayo Clinic Area

Rochester

$70

$81 total

includes taxes & fees

Sep 13 - Sep 14

Egyptian cotton sheets, premium bedding, pillowtop beds, minibar

Home2 Suites by Hilton Rochester Mayo Clinic Area

Rochester

$115

$132 total

includes taxes & fees

Aug 27 - Aug 28

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Go beyond your typical stay in Byron

Pet friendly

Family friendly

Pool

Hot tub

Top landmarks in Byron

Somerby Park

Somerby Park is worth a visit, located 0.8 mi (1.3 km) from central Byron.

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Oxbow Park

8.8/10 (5 reviews)

Oxbow Park is 3.4 mi (5.5 km) from central Byron, why not stop by during your stay. Our travelers also like this walkable area for its restaurants. If you like Oxbow Park, you'll love Douglas State Trail Head Rochester, just a short drive away.

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Cheery Meadows Center

If you like shopping, take time out to go to Cheery Meadows Center when in Byron.

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Salem Glen Winery

Travelers might want a tour of Salem Glen Winery, just one of the places to visit, and located 7.3 mi (11.8 km) from central Byron.

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Salem Town Hall

Salem Town Hall is worth a visit, located 3.7 mi (6 km) from central Byron.

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High Point Shopping Center

If you like shopping, take time out to go to High Point Shopping Center when in Byron. Splash some more cash at Byron Town Square.

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Somerby Golf Club

You might want to practice your swing at Somerby Golf Club, a golf course located 1.2 mi (1.9 km) from central Byron. If Somerby Golf Club doesn't quite scratch your golfing itch, Putting Green, and Links of Byron Mini Golf are also nearby.

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Valley View Park

Valley View Park is worth a visit, located 0.4 mi (0.6 km) from central Byron.

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Check out reviews of Byron hotels guests love

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

10/10 Excellent

"We loved this property! The pool was fun for every age. It was very nice to have the bedroom with full bath plus another half bath in the living room area."

Kahler Inn and Suites - Mayo Clinic Area

8/10 Good

"the air handler was noisy and room felt damp"

Med City Inn & Suites - Mayo Clinic Area

10/10 Excellent

"We had an issue with our first room battery was dead on door lock so they were able to move us. We appreciated the accomadati9n and the breakfast. Staff was helpful. Could use maybe a swing or slide outside by the dinosaur statue. My son pived it."

Aspen Select

10/10 Excellent

"It was nice that we could just walk across the street to the hospital each day. Nice and friendly staff!"

Super 8 by Wyndham Rochester Mayo Clinic Area

10/10 Excellent

"Unforgettable nights"

Hampton Inn Rochester-South

10/10 Excellent

"Everything functioned as it should."

Kahler Grand Hotel

10/10 Excellent

"The location could not be better."

Brentwood Inn & Suites

8/10 Good

"I find the Brentwood a very good place to stay when I am visiting the Mayo Clinic. My room is always ready when I arrive in town and the staff helpful. The room is clean and adequate for I want for my one-night stay. I particularly like the free or included parking fee and best of all the connection to the subway directly from the hotel. The price point is attractive for the accommodations."

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

10/10 Excellent

"The shuttle to Mayo and St Mary's was super convenient and reliable."

Frequently asked questions

What hotels do travelers recommend in Byron?

Guests like Kahler Grand Hotel, Med City Inn & Suites - Mayo Clinic Area and Kahler Inn and Suites - Mayo Clinic Area.

Can I book refundable accommodations in Byron?

If you're looking for the flexibility to change your plans to Byron, most properties provide refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in Byron be like during my vacation?

July and August are typically the warmest months in Byron when the average temp is 67°F. January and February are the coldest months when the average temperature is 21°F. June and May are the months with the most rain.

Why should I book my Byron hotel with Hotels.com?

There are lots of reasons to book your Byron trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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