Hotels in Clarksdale

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Where to stay in Clarksdale?

A pool area with a rock formation backdrop, a wooden post, and a sign indicating a clinic.

A hotel room with a large bed, a fireplace, a TV, and a jacuzzi.

A wooden reception desk with a moose mural, a mounted cow head, and a framed map on the wall.

A cozy log cabin interior with a fireplace, wooden furniture, and a television.

1. Stoney Creek Hotel St. Joseph

St. Joseph

$105

$122 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with a bed, a sofa, a small table, a microwave, and a TV.

A coffee station with two coffee machines and a sign that reads 'MUST. HAVE. COFFEE.'

A coffee station with two coffee machines, a coffee press, and various coffee pods and cups.

A hotel reception area with two reception desks, a wall-mounted sign, and a patterned carpet.

2. Holiday Inn Express Hotel & Suites St. Joseph by IHG

St. Joseph

$114

$132 total

includes taxes & fees

Nov 1 - Nov 2

An indoor swimming pool with clear lane markings, a lifeguard chair, and a pool ladder.

A reception desk with a clock, a framed picture, and a wall with a 'smile' sign.

A Hampton Inn by Hilton building with a modern facade, large windows, and a well-lit entrance.

A snack and beverage vending area with various snack options and refrigerated beverage dispensers.

3. Hampton Inn St. Joseph

St. Joseph

$93

$107 total

includes taxes & fees

Nov 1 - Nov 2

A lobby with a seating area, a reception desk, and a chandelier.

A hotel lobby with a reception desk, seating area, and a refrigerator.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

A hotel room with a kitchenette, a sofa, a bench, a lamp, and a framed picture on the wall.

4. Drury Inn & Suites St Joseph

St. Joseph

$110

$127 total

includes taxes & fees

Oct 25 - Oct 26

A modern living room with a blue sofa, a fireplace, and a stone accent wall.

A Fairfield Inn & Suites Marriott hotel entrance with a modern design, including a prominent overhang and a stone pillar.

A modern hotel lobby with a stone fireplace, blue sofas, a round table, and large windows offering a view of the parking lot.

A restaurant with a long wooden table, chairs, and a bar area.

5. Fairfield Inn & Suites by Marriott St. Joseph

St. Joseph

$114

$132 total

includes taxes & fees

Oct 25 - Oct 26

A modern living area with a sofa, coffee table, and a dining table with chairs.

A compact kitchen with a refrigerator, microwave, sink, and wooden cabinets.

A multi-story hotel with a stone facade, multiple windows, and a parking lot.

A hotel room with two beds, a desk, a chair, a television, and a window with blinds.

6. Woodspring Suites St. Joseph

St. Joseph

$94

$109 total

includes taxes & fees

Oct 21 - Oct 22

A hotel room with two beds, a desk, a television, and a bathroom visible through an open door.

A hotel with a covered outdoor area, a brick building, and a sign for a nearby Subway.

A cozy room with a coffee machine, a clock, and a potted plant.

A modern kitchen with granite countertops, wooden cabinets, and a central island.

7. SureStay Hotel by Best Western Cameron

Cameron

$78

$86 total

includes taxes & fees

Oct 27 - Oct 28

A hotel bathroom with a wooden bathtub, a desk with a lamp, a chair, a television, and a microwave.

A hotel room with a bed, a desk with a computer, a chair, a TV, and a window with a view.

A two-story building with a covered parking area and a brick facade.

A reception area with a marble counter, a fish tank, a welcome sign, and a 'Super 8' sign.

8. Super 8 by Wyndham Cameron

Cameron

$88

$96 total

includes taxes & fees

Oct 30 - Oct 31

A multi-story hotel with a 'My Place' sign, featuring a stone facade and a covered entrance.

A modern restaurant with a bar area, seating arrangements, and a kitchen in the background.

9. My Place Hotel St Joseph MO

St. Joseph

$85

$99 total

includes taxes & fees

Nov 8 - Nov 9

A spacious kitchen with wooden cabinets, a dining area with a table and chairs, and a hallway leading to another room.

A hotel room with a bed, a desk, a chair, a television, and an air conditioning unit.

A multi-story hotel with a flat roof, a swimming pool, and a fenced parking area.

A hotel room with a bed, a desk with a computer, a microwave, a red chair, and a window with curtains.

10. Red Roof Inn Cameron

Cameron

$91

$101 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with a sofa, two beds, a patterned ottoman, a wall art piece, and a window with a view.

A hotel room with a desk, chair, television, sofa, ottoman, and a window with a patterned curtain.

A breakfast bar with waffle makers, a coffee maker, and a fruit bowl.

A multi-story hotel with a prominent 'HOME 2' sign, outdoor seating area, and a covered entrance.

11. Home2 Suites By Hilton St. Joseph

St. Joseph

$135

$156 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with two beds, a desk, a chair, and a television.

A hallway with a 7UP vending machine, white doors, and a brown mat.

A vending machine with snacks and a 7UP machine in a hallway with a staircase.

A hotel reception area with a wooden counter, a coffee machine, a phone, and a television.

12. Motel 6 Saint Joseph, MO

St. Joseph

$60

$69 total

includes taxes & fees

Nov 1 - Nov 2

A swimming pool with a hot tub, a ladder, and a slide.

A hotel room with a brown sofa, a wooden coffee table, a desk with a chair, and a lamp. There are three framed pictures on the wall, a window with curtains, and a radiator.

A reception area with a reception desk, a plant, a coffee station, and a sign for breakfast.

A hotel room with a large bed, two bedside tables with lamps, a desk, and a chair.

13. Quality Inn Cameron

Cameron

$108

$120 total

includes taxes & fees

Nov 19 - Nov 20

A hotel room with a large bed, a red wall, and a cityscape painting above the bed.

A hotel room with a television, a lamp, a microwave, and a desk with a chair.

A reception desk with a clock, decorative wall art, and American flags.

14. AmeriStay Inn

St. Joseph

$75

$87 total

includes taxes & fees

Oct 26 - Oct 27

A large, historic brick building with a prominent tower and a grand entrance.

A traditional interior with a fireplace, wooden furniture, and a chandelier.

A brick building with a covered porch and a large bush of white flowers.

A traditional room with a fireplace, ornate chandelier, and classic furniture.

15. Vineyard Mansion & Carriage House Bed & Breakfast

St. Joseph

$102

$151 total

includes taxes & fees

Oct 23 - Oct 24

A large brick building with multiple windows and a covered porch area.

A red brick building with a garden in front.

A traditional interior with a fireplace, a wooden staircase, and a patterned floor.

A covered porch with columns, potted plants, and a brick wall.

16. Whiskey Mansion

St. Joseph

$156

$181 total

includes taxes & fees

Oct 21 - Oct 22

A gazebo with a metal roof and wooden benches.

A lobby with a fireplace, a table with four chairs, and a patterned carpet.

A hotel room with two beds, a nightstand with a lamp, a small table, a mirror, and a window.

A hotel room with a wooden desk, two red chairs, a TV mounted on the wall, a mirror, and a wardrobe.

17. Econo Lodge Cameron

Cameron

$75

$83 total

includes taxes & fees

Nov 9 - Nov 10

A balcony with a stainless steel refrigerator, a wicker chair, and an air conditioning unit.

A building with a covered entrance, a small patio with chairs, and a window with blinds.

A motel with a large sign, a parking lot, and a building with a sloped roof.

A cluttered office space with a desk, computer, printer, and various office supplies.

18. Capri Motel By OYO Elwood, Wathena

Wathena

$75

$90 total

includes taxes & fees

Oct 31 - Nov 1

A reception desk with a "WELCOME" sign, a clock, and a mirror.

A compact kitchenette with a microwave, sink, and small refrigerator.

A hotel room with two beds, a desk with a chair, a microwave, a TV, and a small shelf with toiletries.

A kitchenette with a coffee machine, a trash can, and a sign indicating coffee service hours.

19. Motel 6 Cameron, MO

Cameron

$75

$82 total

includes taxes & fees

Oct 21 - Oct 22

View all properties

Go beyond your typical stay in Clarksdale

Check out reviews of Clarksdale hotels guests love

Holiday Inn Express Hotel & Suites St. Joseph by IHG

St. Joseph

10/10 Exceptional

Robert

Red Roof Inn Cameron

Cameron

10/10 Exceptional

We really enjoyed our stay in Springfield, IL and also our stay in Cameron, IL. I was impressed by the hospitality, cleanliness, comfortable bedding, the delicious snacks offered in the lobby and the accommodations offered to allow 3 adults and 2 children to all share a single room, saving us a good bit of money! The girls also enjoyed the hotel pool and the free breakfast was delicious both mornings in Springfield.

Shannon

Woodspring Suites St. Joseph

St. Joseph

10/10 Exceptional

Jeff

Super 8 by Wyndham Cameron

Cameron

10/10 Exceptional

Cathy

Hampton Inn St. Joseph

St. Joseph

10/10 Exceptional

marcie

Vineyard Mansion & Carriage House Bed & Breakfast

St. Joseph

10/10 Exceptional

This was our first experience with a B&B and this property did not disappoint. For a house that is over 130 years old it was very comfortable even the bed lines were luxurious. It was a hot weekend in St Joe and I had concerns about the A/C but the lower level of the house had central air and our room had a window unit that was more than adequate and even quiet. The modern kitchen and pantry were well stocked. This property has become our go to place to stay when visiting St Joe. We highly...

Brian

SureStay Hotel by Best Western Cameron

Cameron

10/10 Exceptional

Dawn

Whiskey Mansion

St. Joseph

10/10 Exceptional

I can't say enough good things about the Whiskey Mansion Inn. The house is gorgeous, it's been beautifully renovated, and the rooms are lovely. Our room was comfortable and had everything we needed, but it was also exquisitely decorated with excellent attention to detail. The Inn owner was gracious and welcoming, and gave us thoughtful recommendations for seeing the town. His lunch recommendation ended up being the best pizza we've ever had! If you are going to St. Joe, STAY HERE!

John

Motel 6 Cameron, MO

Cameron

10/10 Exceptional

Terrence

Frequently Asked Questions

Can I book a refundable hotel in Clarksdale?

If you're looking for the flexibility to change your plans to Clarksdale, most accommodations offer refundable* rates you can book. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Clarksdale be like during my visit?

The warmest months in Clarksdale are usually July and August with an average temp of 74°F. January and February are the chilliest months when the average temp is 33°F. The rainiest months are May and July.

Why should I book my Clarksdale hotel with Hotels.com?

There are plenty of reasons to book your Clarksdale travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.