Hotels in Medora

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Check prices for these dates

Tonight
Dec 23 - Dec 24
Tomorrow
Dec 24 - Dec 25
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

Where to stay in Medora?

In-room safe, blackout drapes, iron/ironing board
Super 8 by Wyndham Jerseyville
Super 8 by Wyndham Jerseyville
2.0 star property
8.0 out of 10, Very Good, (332)
  • cleanliness
    Take a break at this convenient Jerseyville motel with free breakfast daily.
The price is $82
$91 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Super 8 by Wyndham Jerseyville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Check out reviews of Medora hotels guests love

Holiday Inn Express and Suites Alton St Louis Area by IHG

Holiday Inn Express and Suites Alton St Louis Area by IHG

10/10 Excellent
"Yes but there were no tissue. Staff said they were on order"
Rhonda 1-night trip
Posted 2 days ago
Holiday Inn Express and Suites Alton St Louis Area by IHG

Frequently asked questions

Can I book a refundable hotel in Medora?
If you want the flexibility to change your plans to Medora, most accommodations provide refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in Medora be like during my vacation?
The warmest months in Medora are usually July and August with an average temp of 74°F. January and February are the chilliest months when the average temp is 36°F. The rainiest months are May and April.
Why should I book my Medora hotel with Hotels.com?
There are plenty of reasons to book your Medora travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.