A city skyline with modern buildings and a park with a lake.

Hotels in South Main

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Where to stay in South Main?

A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.

A Comfort Suites hotel entrance with a covered walkway, a sign, and a parking area.

A spacious lobby with a reception desk, two sofas, a coffee station, and large windows providing natural light.

A hotel room with a blue sofa, a desk with a lamp, a chair, a window with curtains, and two framed pictures on the wall.

1. Comfort Suites Houston near Medical Center- NRG Stadium

South Main

nancy

$80

$94 total

includes taxes & fees

Nov 1 - Nov 2

A modern lobby with a blue carpet, seating area, and large windows.

A banquet hall with round tables set for a formal event, featuring floral centerpieces and elegant table settings.

A spacious hall with a patterned carpet, a red curtain backdrop, and a grand chandelier.

A lobby with a bar area, leather seating, and a stone wall.

2. Wyndham Houston at Reliant Park & Medical Center

South Main

Charmin

$98

$115 total

includes taxes & fees

Oct 5 - Oct 6

A spacious lobby with a central seating area, a bar, and a reception desk.

A gym with various exercise equipment, including treadmills and weight machines, and a large window providing a view of the outside.

A modern living room with a fireplace, sofas, and a flat-screen TV.

A spacious indoor dining area with multiple tables and chairs, large windows, and hanging pendant lights.

3. Wingate Houston near Reliant Park/Medical Center

South Main

Deborah

$99

$116 total

includes taxes & fees

Oct 5 - Oct 6

A hotel room with a blue sofa, striped armchair, a small table, a TV on a cabinet, a microwave, and a door leading to a bedroom.

A hotel room with a large bed, two bedside tables, a nightstand, a mirror, and a window with curtains.

A vending machine and a Coca-Cola refrigerator in a hallway with tiled flooring and a ceiling with fluorescent lights.

A self-service breakfast bar with a coffee machine, cereal dispensers, and a refrigerated display.

4. Quality Inn & Suites NRG Park - Medical Center

South Main

HERBERT

$72

$84 total

includes taxes & fees

Oct 26 - Oct 27

A compact kitchen with dark cabinets, a microwave, a coffee maker, and a white countertop. There are two wicker chairs and a small table.

A hotel room with a dining table, a sofa, a TV, and a kitchen area.

A hotel room with a bed, a sofa, a table, a framed picture on the wall, and a bathroom visible through an open door.

A compact kitchen with a dining table, chairs, a coffee maker, and a refrigerator.

5. Candlewood Suites Houston Medical Center by IHG

South Main

Barbara

$74

$87 total

includes taxes & fees

Oct 11 - Oct 12

A glass door leading to an outdoor seating area with wicker furniture and cushions.

A modern kitchen with white cabinetry, a built-in oven, and a refrigerator.

A covered patio area with wicker furniture, a table, and a chair.

A modern residential building with a swimming pool, multiple balconies, and a covered outdoor area.

6. 3 BR Condo near Reliant/NRG Stadium

South Main

$127

$388 total

includes taxes & fees

Oct 6 - Oct 7

A spacious dining area with multiple tables and chairs, large windows, and hanging pendant lights.

A coffee station with two coffee machines and a variety of coffee pods and cups.

A hotel room with a bed, a desk, a chair, a sofa, and a TV.

A Holiday Inn Express & Suites hotel with a glass entrance, multiple floors, and a view of the surrounding neighborhood.

7. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

1.4 km from South Main

Martha

$118

$139 total

includes taxes & fees

Oct 7 - Oct 8

A bar area with a long counter, bar stools, a refrigerated display case with beverages, and a menu board above the counter.

A GoBoard® displaying the time, weather, and news.

A Courtyard by Marriott hotel with a central courtyard, multiple floors, and a parking lot.

A hotel pool area with a bar, seating, and a view of the building's exterior.

8. Courtyard By Marriott Houston Medical Center Reliant Park

2.7 km from South Main

Vicki

$121

$143 total

includes taxes & fees

Oct 11 - Oct 12

A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.

A multi-story hotel with a rooftop pool area, featuring a modern design and multiple balconies.

A modern reception area with a wooden reception desk, a coffee machine, and a seating area with a sofa and armchairs.

A spacious indoor area with high ceilings, large windows, and modern furniture.

9. Hyatt Place Houston Medical Center

Texas Medical Center, 3.1 km from South Main

Eduardo

$126

$149 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with a large bed, a flat-screen TV, a painting on the wall, and a view of the city through large windows.

A modern hotel room with a grey sectional sofa, a flat-screen TV, a desk with a lamp, and a cityscape view.

10. Hyatt House Houston Medical Center

Texas Medical Center, 3.1 km from South Main

Kathleen

$134

$158 total

includes taxes & fees

Oct 11 - Oct 12

A modern restaurant with a bar area, wooden flooring, and a variety of seating options including tables and chairs.

A restaurant with wooden tables and chairs, a bar area, and a green wall with a TV.

A modern interior with a seating area, a bar with a green wall, and a window with artwork.

A hotel room with a bed, a desk, a chair, a TV, and a wardrobe.

11. Hotel Ylem

2.3 km from South Main

Cynthia

$81

$100 total

includes taxes & fees

Oct 12 - Oct 13

A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

A modern bar area with a long counter, multiple seating options, and a variety of liquor bottles on shelves.

A dining table set with plates, cutlery, glasses, and candles, surrounded by chairs in a formal dining area.

An outdoor patio area with seating and a pool.

12. Hilton Houston Plaza/Medical Center

Texas Medical Center, 4.4 km from South Main

Tracey

$100

$119 total

includes taxes & fees

Oct 11 - Oct 12

A person sitting on a white lounge chair with a striped towel, reading a book.

A bar area with a long counter, multiple shelves with bottles, and a television screen.

A modern hotel room with a wooden desk, yellow chair, and a sofa with cushions. There is a round mirror on the wall and a painting above the sofa.

A hotel room with a large bed, a bench, a television, and a window with a city view.

13. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Greenway Plaza-Upper Kirby, 6.5 km from South Main

Kristian

$69

$81 total

includes taxes & fees

Oct 5 - Oct 6

A rooftop pool area with lounge chairs and a view of a tall building at night.

A modern hotel lobby with a bar area, seating arrangements, and a reception desk.

A rooftop terrace with outdoor seating, a pool, and city views.

A modern hotel with a prominent glass facade, a flat roof, and a ground-level entrance with a covered walkway.

14. The Westin Houston Medical Center/Museum District

Texas Medical Center, 4.4 km from South Main

Jennifer Noel

$170

$212 total

includes taxes & fees

Oct 11 - Oct 12

A reception area with a wooden reception desk, two refrigerators, and clocks displaying different city names.

A Best Western Plus hotel with a modern design, featuring a large geometric pattern on the facade.

A modern hotel lobby with a bar area, seating arrangements, and artwork on the walls.

A hotel room with two beds, a desk with a chair, a television, and a mirror.

15. Best Western Plus Pearland/Houston Medical Center Hotel

Southeast Houston, 10.2 km from South Main

Quyen

$83

$97 total

includes taxes & fees

Oct 11 - Oct 12

A spacious living area with a dining table, chairs, and a chandelier.

A high-rise hotel with a rooftop pool, multiple floors, and a city skyline in the background.

A hotel room with a bed, a nightstand, a desk with a chair, a large mirror, and a chandelier.

A restaurant with tables set for dining, surrounded by wicker chairs and potted plants.

16. Hotel Zaza Houston Museum District

6.3 km from South Main

Brenda

$276

$370 total

includes taxes & fees

Oct 8 - Oct 9

A hotel pool area with a pool, lounge chairs, and umbrellas.

A lobby with a round glass table, green chairs, a fireplace, and a reception desk.

A Hilton Garden Inn with a green roof, multiple floors, and a central entrance.

An outdoor patio with tables and chairs, large umbrellas, and a building with large windows in the background.

17. Hilton Garden Inn Houston-Pearland

10.6 km from South Main

LaTanya

$88

$100 total

includes taxes & fees

Oct 12 - Oct 13

A hotel entrance with a covered walkway, a 'No Parking' sign, and a 'Home 2 Suites by Hilton' sign.

A hotel room with a kitchenette, a bed, a bathroom, and a view of the hallway.

A balcony with a view of a city skyline, a blue sofa, and a tiled floor.

An indoor swimming pool with lounge chairs and yellow chairs around it.

18. Home2 Suites by Hilton at the Galleria

Greater Uptown, 8 km from South Main

Jarie

$106

$124 total

includes taxes & fees

Oct 26 - Oct 27

A spacious room with large windows, a red armchair, a small table, and a cabinet with decorative items.

A modern hotel room with a bed, a desk with a chair, a flat-screen TV, and a wall-mounted ironing board.

A vending machine stocked with various beverages and snacks, including sodas, energy drinks, and packaged foods.

A long, narrow hallway with doors on both sides, a carpeted floor, and a ceiling with recessed lighting and smoke detectors.

19. Studio 6 Houston, TX – Pearland/Medical Center

Southeast Houston, 12.9 km from South Main

Athens

$60

$70 total

includes taxes & fees

Oct 5 - Oct 6

A hotel lobby with a hot tub, a pool, and a dining area.

A spacious lobby with a high ceiling, a mezzanine level, and a variety of seating options including sofas and armchairs.

A hotel room with a large bed, a desk with a TV, a chair, a lamp, and a cityscape painting on the wall.

A hotel lobby with a reception desk, seating area, and a television mounted on the wall.

20. Drury Inn & Suites Houston Near the Galleria

The Galleria, 9.4 km from South Main

Juan

$102

$119 total

includes taxes & fees

Oct 11 - Oct 12

View all properties

Compare popular hotels in South Main

Property	Property class	Guest rating
Wingate Houston near Reliant Park/Medical Center	6.6 Good 1,004 reviews	View
Comfort Suites Houston near Medical Center- NRG Stadium	8.8 Excellent 1,000 reviews	View
Wyndham Houston at Reliant Park & Medical Center	7.2 Good 1,423 reviews	View
Candlewood Suites Houston Medical Center by IHG	7.4 Good 897 reviews	View
Quality Inn & Suites NRG Park - Medical Center	6.6 Good 1,000 reviews	View