Hotels in South San Francisco

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Oct 17 - Oct 18
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Oct 18 - Oct 19
Next weekend
Oct 23 - Oct 25
In two weeks
Oct 30 - Nov 1

Where to stay in South San Francisco?

A hotel lobby with a central reception desk, large columns, and hanging pendant lights.
A hotel entrance with a covered area, multiple floors, and a well-lit facade.
A patio area with outdoor seating, palm trees, and a building with large windows.
A kitchen with a granite countertop, a built-in wine rack, and a flat-screen TV mounted on the wall.

1. Hilton Garden Inn San Francisco Arpt North

Hilton Garden Inn San Francisco Arpt North
The East Side
$98
$115 total
includes taxes & fees
Oct 23 - Oct 24
Hilton Garden Inn San Francisco Arpt North
A multi-level hotel atrium with outdoor seating areas, a pool, and a central lounge.
A modern hotel lobby with a buffet area featuring a variety of food items and a coffee station.
A large indoor swimming pool with clear water, surrounded by lounge chairs and potted plants.
A modern hotel with a curved facade, multiple floors, and a well-lit entrance.

2. Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point
The East Side
$138
$163 total
includes taxes & fees
Nov 13 - Nov 14
Embassy Suites by Hilton San Francisco Airport Oyster Point
A spacious, modern living area with a high ceiling, large windows, and a variety of seating options including sofas and chairs.
A modern kitchen with a central island, bar stools, and a large window.
A modern interior with a long bench, decorative wall art, and a planter with large green plants.
A coffee shop interior with a branded sign, shelves stocked with snacks, a coffee machine, and a refrigerated display.

3. DoubleTree by Hilton San Francisco South Airport Blvd

DoubleTree by Hilton San Francisco South Airport Blvd
South San Francisco
$122
$144 total
includes taxes & fees
Oct 25 - Oct 26
DoubleTree by Hilton San Francisco South Airport Blvd
An outdoor patio with modern seating, a fire feature, and string lights.
A compact kitchen with a dishwasher, a microwave, and a built-in oven. There is a dining area with a table and chairs.
A modern hotel lobby with a seating area, a reception desk, and large windows offering a view of the parking area.
A hotel room with a wooden wall, a dining table with yellow chairs, a grey sofa, and a brown ottoman.

4. Home2 Suites by Hilton San Francisco Airport North

Home2 Suites by Hilton San Francisco Airport North
The East Side
$112
$131 total
includes taxes & fees
Nov 6 - Nov 7
Home2 Suites by Hilton San Francisco Airport North
A bar area with a curved wooden counter, bar stools, and a glass display case filled with bottles.
A hotel lobby with blue seating, a coffee table, and a patterned rug.
A hotel room with a sofa set, a coffee table, a TV, and a patterned carpet.
A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

5. Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel
South San Francisco
$107
$125 total
includes taxes & fees
Oct 31 - Nov 1
Best Western Plus Grosvenor Airport Hotel
Exterior
An outdoor patio area with seating and a building in the background.
A spacious lobby with a wooden floor, seating areas, a reception desk, and a bar area with shelves.
A hotel room with two beds, a desk, a television, and a balcony with curtains.

6. Sonesta Select San Francisco Airport Oyster Point Waterfront

Sonesta Select San Francisco Airport Oyster Point Waterfront
Oyster Point
$112
$132 total
includes taxes & fees
Oct 25 - Oct 26
Sonesta Select San Francisco Airport Oyster Point Waterfront
A modern living room with a stone wall, a flat-screen TV, leather sofas, and a dining area with natural light.
A hotel room with a desk, a sofa, a TV, a window with a view of trees, and a lamp.
A modern lobby with a seating area, a flat-screen TV, a stone accent wall, and large windows.
A hotel room with a sofa, a wooden table, a bed, a desk, a TV, and a large window with a view of a forest.

7. Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area

Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area
The East Side
$130
$151 total
includes taxes & fees
Oct 23 - Oct 24
Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area
A spacious lobby with a central seating area, a reception desk, and a second-floor balcony.
A hotel room with a bed, a TV, a desk, a kitchenette, and a seating area with a sofa and armchairs.
A Holiday Inn Express hotel with a well-lit entrance, a parking lot, and a clear sky.
A Holiday Inn Express reception desk with a blue and white color scheme and a large 'H' logo.

8. Holiday Inn Express San Francisco-Airport North by IHG

Holiday Inn Express San Francisco-Airport North by IHG
South San Francisco
$106
$136 total
includes taxes & fees
Oct 25 - Oct 26
Holiday Inn Express San Francisco-Airport North by IHG
A modern building entrance with a covered walkway, large glass doors, and potted plants.
A hotel room with a double bed, a desk with a chair, a large mirror, a sink with a vanity, and a small bathroom area.
A hotel lobby with seating areas, a reception desk, and a bar.
A hotel hallway with an elevator, a red carpet, and a decorative wall piece.

9. Hampton Inn San Francisco Airport

Hampton Inn San Francisco Airport
The East Side
$114
$135 total
includes taxes & fees
Nov 8 - Nov 9
Hampton Inn San Francisco Airport
A La Quinta hotel with a modern facade, a covered entrance, and a parking lot.
A modern kitchen with a central island, wooden cabinets, and stainless steel appliances.
A modern living room with a grey sofa, a wooden coffee table, and a vibrant pink armchair. A kitchen area with a countertop and sink is visible in the background.
A gym with treadmills, a spinning machine, and various exercise equipment.

10. La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Downtown South San Francisco
$121
$141 total
includes taxes & fees
Nov 12 - Nov 13
La Quinta Inn & Suites by Wyndham San Francisco Airport N
A courtyard with outdoor seating, a glass table, and potted plants.
A hotel room with two beds, a wooden headboard, a bedside table with a lamp, and a window with curtains.
A restaurant with wooden cabinets, red upholstered chairs, and a counter with coffee machines and food displays.
A hotel lobby with wooden furniture, a fireplace, and framed pictures on the walls.

11. Comfort Inn and Suites San Francisco Airport North

Comfort Inn and Suites San Francisco Airport North
The East Side
$100
$117 total
includes taxes & fees
Oct 25 - Oct 26
Comfort Inn and Suites San Francisco Airport North
A hotel room with a bed, bedside lamps, a framed picture on the wall, and a vase with flowers.
A room with a flat-screen TV mounted above a fireplace, two benches in front, and a wooden floor.
A circular outdoor seating area with red Adirondack chairs and a central fire pit.
A multi-story hotel with a central entrance, a parking lot, and a signboard.

12. Hotel Focus SFO

Hotel Focus SFO
The East Side
$98
$115 total
includes taxes & fees
Oct 30 - Oct 31
Hotel Focus SFO
An outdoor dining area with tables and chairs, surrounded by glass walls and trees.
The exterior of the AC Hotel South San Francisco with a modern facade, large glass windows, and a well-lit entrance.
A modern bar area with a large TV screen, bar stools, and a view of a body of water.
A modern hotel room with a large bed, a sofa, a desk, and a view of the ocean.

13. AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
Oyster Point
$166
$196 total
includes taxes & fees
Nov 1 - Nov 2
AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
A modern hotel room with a sectional sofa, a wooden coffee table, a desk with a chair, a TV mounted on the wall, and a large window with sheer curtains.
A hotel named 'Four Points by Sheraton' with a modern design, featuring a curved facade and multiple windows.
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.
A teal armchair with a matching ottoman, a floor lamp, a small side table, and a curtain.

14. Four Points by Sheraton Hotel & Suites San Francisco Airport

Four Points by Sheraton Hotel & Suites San Francisco Airport
South San Francisco
$111
$130 total
includes taxes & fees
Oct 25 - Oct 26
Four Points by Sheraton Hotel & Suites San Francisco Airport
A modern living room with a fireplace, a TV, a sofa, and a dining area with chairs.
A spacious dining area with high ceilings, large windows, and a variety of seating arrangements.
A multi-story hotel with a parking lot, surrounded by trees and a view of the ocean.
A modern lounge area with seating, a refrigerator stocked with beverages, and a view through a glass door.

15. Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
Oyster Point
$151
$178 total
includes taxes & fees
Nov 7 - Nov 8
Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
A stone facade with a sign for Larkspur Landing Home Suite Hotel, a lantern, and a flower bed.
A multi-story hotel with a central entrance, balconies, and a parking area.
A hotel breakfast area with a counter displaying bread, pastries, and a coffee station. There are two lamps on either side of the counter, and a menu sign is visible.
A hotel room with two beds, a TV, a dresser, and a window with curtains.

16. Larkspur Landing Extended Stay Suites South San Francisco

Larkspur Landing Extended Stay Suites South San Francisco
The East Side
$142
$166 total
includes taxes & fees
Nov 9 - Nov 10
Larkspur Landing Extended Stay Suites South San Francisco
A hotel room with a bed, desk, chair, television, and a microwave.
A breakfast bar with various food items and a sign that says "Healthy."
A gym with cardio machines, weight machines, and a TV screen.
A hotel with a prominent entrance, a covered walkway, and a parking area.

17. Hotel Nova SFO

Hotel Nova SFO
South San Francisco
$130
$152 total
includes taxes & fees
Oct 18 - Oct 19
Hotel Nova SFO
A hotel room with a large window, a flat-screen TV, a glass coffee table, two wooden chairs, a patterned rug, and a potted plant.
A hotel room with two beds, each with a wooden headboard, white bedding, and a blue patterned throw. There is a nightstand with a lamp between the beds, and two framed artworks on the walls.
A Travelodge hotel with a modern design, featuring a prominent sign, a covered entrance, and a bench outside.
A rectangular swimming pool with a clear blue water, surrounded by lounge chairs and a covered seating area.

18. Travelodge by Wyndham San Francisco Airport North

Travelodge by Wyndham San Francisco Airport North
South San Francisco
$77
$92 total
includes taxes & fees
Nov 15 - Nov 16
Travelodge by Wyndham San Francisco Airport North
An indoor courtyard with a stone floor, a round table with chairs, and potted plants.
A reception area with a wooden desk, a vase of flowers, a map, and a view of the outside.
A hallway with potted plants, a bench, and a reception desk.
A courtyard with a flat roof, potted plants, and outdoor seating.

19. Airport Inn

Airport Inn
Downtown South San Francisco
$122
$143 total
includes taxes & fees
Nov 1 - Nov 2
Airport Inn
A modern hotel room with a large bed, a cityscape painting, a round mirror, a wooden nightstand, and a desk with a chair.
A reception desk with a logo for Days Inn by Wyndham, a white wall, and a ceiling with recessed lighting.
Breakfast area
A modern kitchen with a refrigerator, a sink, and a countertop.

20. Days Inn by Wyndham San Francisco S/Oyster Point Airport

Days Inn by Wyndham San Francisco S/Oyster Point Airport
Paradise Valley
$116
$144 total
includes taxes & fees
Oct 18 - Oct 19
Days Inn by Wyndham San Francisco S/Oyster Point Airport
View all properties

You may also like family-friendly hotels in South San Francisco

A multi-level hotel atrium with outdoor seating areas, a pool, and a central lounge.
A modern hotel lobby with a buffet area featuring a variety of food items and a coffee station.
A large indoor swimming pool with clear water, surrounded by lounge chairs and potted plants.
A modern hotel with a curved facade, multiple floors, and a well-lit entrance.

Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point
The East Side
$138
$163 total
includes taxes & fees
Nov 13 - Nov 14
Embassy Suites by Hilton San Francisco Airport Oyster Point
A spacious, modern living area with a high ceiling, large windows, and a variety of seating options including sofas and chairs.
A modern kitchen with a central island, bar stools, and a large window.
A modern interior with a long bench, decorative wall art, and a planter with large green plants.
A coffee shop interior with a branded sign, shelves stocked with snacks, a coffee machine, and a refrigerated display.

DoubleTree by Hilton San Francisco South Airport Blvd

DoubleTree by Hilton San Francisco South Airport Blvd
South San Francisco
$122
$144 total
includes taxes & fees
Oct 25 - Oct 26
DoubleTree by Hilton San Francisco South Airport Blvd
A bar area with a curved wooden counter, bar stools, and a glass display case filled with bottles.
A hotel lobby with blue seating, a coffee table, and a patterned rug.
A hotel room with a sofa set, a coffee table, a TV, and a patterned carpet.
A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel
South San Francisco
$107
$125 total
includes taxes & fees
Oct 31 - Nov 1
Best Western Plus Grosvenor Airport Hotel
A hotel lobby with a central reception desk, large columns, and hanging pendant lights.
A hotel entrance with a covered area, multiple floors, and a well-lit facade.
A patio area with outdoor seating, palm trees, and a building with large windows.
A kitchen with a granite countertop, a built-in wine rack, and a flat-screen TV mounted on the wall.

Hilton Garden Inn San Francisco Arpt North

Hilton Garden Inn San Francisco Arpt North
The East Side
$98
$115 total
includes taxes & fees
Oct 23 - Oct 24
Hilton Garden Inn San Francisco Arpt North
An outdoor patio with modern seating, a fire feature, and string lights.
A compact kitchen with a dishwasher, a microwave, and a built-in oven. There is a dining area with a table and chairs.
A modern hotel lobby with a seating area, a reception desk, and large windows offering a view of the parking area.
A hotel room with a wooden wall, a dining table with yellow chairs, a grey sofa, and a brown ottoman.

Home2 Suites by Hilton San Francisco Airport North

Home2 Suites by Hilton San Francisco Airport North
The East Side
$112
$131 total
includes taxes & fees
Nov 6 - Nov 7
Home2 Suites by Hilton San Francisco Airport North
A modern living room with a stone wall, a flat-screen TV, leather sofas, and a dining area with natural light.
A hotel room with a desk, a sofa, a TV, a window with a view of trees, and a lamp.
A modern lobby with a seating area, a flat-screen TV, a stone accent wall, and large windows.
A hotel room with a sofa, a wooden table, a bed, a desk, a TV, and a large window with a view of a forest.

Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area

Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area
The East Side
$130
$151 total
includes taxes & fees
Oct 23 - Oct 24
Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area
Exterior
An outdoor patio area with seating and a building in the background.
A spacious lobby with a wooden floor, seating areas, a reception desk, and a bar area with shelves.
A hotel room with two beds, a desk, a television, and a balcony with curtains.

Sonesta Select San Francisco Airport Oyster Point Waterfront

Sonesta Select San Francisco Airport Oyster Point Waterfront
Oyster Point
$112
$132 total
includes taxes & fees
Oct 25 - Oct 26
Sonesta Select San Francisco Airport Oyster Point Waterfront
A spacious lobby with a central seating area, a reception desk, and a second-floor balcony.
A hotel room with a bed, a TV, a desk, a kitchenette, and a seating area with a sofa and armchairs.
A Holiday Inn Express hotel with a well-lit entrance, a parking lot, and a clear sky.
A Holiday Inn Express reception desk with a blue and white color scheme and a large 'H' logo.

Holiday Inn Express San Francisco-Airport North by IHG

Holiday Inn Express San Francisco-Airport North by IHG
South San Francisco
$106
$136 total
includes taxes & fees
Oct 25 - Oct 26
Holiday Inn Express San Francisco-Airport North by IHG
A courtyard with outdoor seating, a glass table, and potted plants.
A hotel room with two beds, a wooden headboard, a bedside table with a lamp, and a window with curtains.
A restaurant with wooden cabinets, red upholstered chairs, and a counter with coffee machines and food displays.
A hotel lobby with wooden furniture, a fireplace, and framed pictures on the walls.

Comfort Inn and Suites San Francisco Airport North

Comfort Inn and Suites San Francisco Airport North
The East Side
$100
$117 total
includes taxes & fees
Oct 25 - Oct 26
Comfort Inn and Suites San Francisco Airport North
An outdoor dining area with tables and chairs, surrounded by glass walls and trees.
The exterior of the AC Hotel South San Francisco with a modern facade, large glass windows, and a well-lit entrance.
A modern bar area with a large TV screen, bar stools, and a view of a body of water.
A modern hotel room with a large bed, a sofa, a desk, and a view of the ocean.

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
Oyster Point
$166
$196 total
includes taxes & fees
Nov 1 - Nov 2
AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Our prices for hotels in South San Francisco are cheapest in January
Price trends for hotels in South San Francisco
Pricing is based on two traveler single night rates
View properties in October
Typical weather for South San Francisco
October
High 19°C / low 14°C. Sunny most days.
View properties in October
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Monthly weather averages (˚C)

Top neighborhoods in South San Francisco

A panoramic view of San Francisco's South Peninsula, highlighting the city's dense urban areas, rolling hills, and the iconic Golden Gate Bridge in the distance.
An aerial view of a city with a large stadium, several schools, and a dense residential area.
An aerial view of a coastal city with a dense urban area, a large port, and a mountainous backdrop.

Downtown South San Francisco

Downtown South San Francisco buzzes with a blend of biotech innovation and cultural diversity. Corporate towers and colorful murals tell the story of this unique business hub. You'll find authentic taquerias, dim sum houses, and Filipino eateries nestled between modern office campuses along Grand Avenue. The neighborhood comes alive during weekdays when professionals fill its plazas and restaurants. Getting around is a breeze with nearby BART and Caltrain stations connecting you to San Francisco proper and beyond. Business hotels cater mostly to corporate travelers with practical amenities. The area quiets down after work hours, offering a genuine glimpse into Bay Area life away from tourist crowds.

A wooden bridge over a river, surrounded by autumn-colored vegetation and a distant mountain.
A nighttime view of the Golden Gate Bridge with its distinctive orange color and suspension cables.
A modern building complex by a calm river with sparse vegetation.

Oyster Point

Oyster Point balances sleek biotech campuses with stunning San Francisco Bay views. The waterfront promenade offers perfect spots for watching waves crash against the shore or catching a beautiful sunset. Modern plazas feature public art installations while walking paths showcase both cutting-edge architecture and natural bay ecosystems. Business travelers appreciate the corporate hotels with meeting facilities and convenient access to office buildings. Dining options cater primarily to weekday lunch crowds, with most establishments closing early evening. The area is best explored by car, though waterfront paths provide scenic strolling opportunities away from the corporate hustle.

The Golden Gate Bridge with its distinctive red towers and cables, spanning across the San Francisco Bay.
A large, modern bridge with a unique design against a clear blue sky.
Photo by Tonette Pineda✈⛵🚌🚉🚃🚅🚀

The East Side

The East Side delivers authentic local life away from San Francisco's tourist traps. Catch Bay views from San Bruno Point Park or explore diverse family-owned restaurants along Grand Avenue serving up killer tacos and pho. This residential neighborhood mixes Hispanic and Asian influences that shine through local markets and casual eateries. Budget travelers appreciate the affordable motels and extended-stay options that cost way less than downtown San Francisco. Buses connect to BART and Caltrain, though having wheels helps. Most spots close early, so plan your food adventures accordingly.

A mountainous landscape with rolling hills, dense forests, and a distant view of hills.

Paradise Valley

Paradise Valley offers a peaceful retreat from San Francisco's bustle while keeping you close to the action. This quiet residential neighborhood in South San Francisco balances suburban calm with convenient access to nearby attractions. Take a stroll through San Bruno Point Park or venture to local spots like K1 Speed for some indoor racing fun. Budget-friendly accommodations make Paradise Valley an appealing base for Bay Area exploration. The neighborhood's proximity to San Francisco International Airport and major highways ensures easy connections throughout the region. With ample street parking and minimal crowds, you'll appreciate this low-key alternative to the city's more hectic districts.

The Golden Gate Bridge spanning the Golden Gate Strait, with a city skyline in the background.

Serra Highlands

Serra Highlands offers a peaceful retreat from the Bay Area buzz with its hillside streets and family-friendly vibe. While there aren't tourist attractions within the neighborhood itself, you'll enjoy stunning panoramic views, quiet walking paths, and easy access to nearby highlights like Serramonte Center. Morning fog rolling over the hills creates a mystical atmosphere worth waking up for. Getting around requires a car or rideshare, as public transit is limited in this residential area. Accommodations consist mainly of vacation rental homes with suburban comforts like driveways and yards. For dining and shopping, you'll need to venture to surrounding commercial areas, making Serra Highlands perfect for travelers seeking authentic local living.

Top landmarks in South San Francisco

San Bruno Point Park

7.8/10 (451 reviews)
If you like quiet time surrounded by flowers and greenery, hang out at San Bruno Point Park in The East Side. Our travelers also like this walkable area for its restaurants. Want to stretch your legs some more? Head to Bayfront Park and John McLaren Park, both nearby.
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South San Francisco Convention Center

7.8/10 (668 reviews)
South San Francisco Convention Center is worth a visit, located 0.5 mi (0.8 km) from central South San Francisco. Hotels.com travelers also say the area is artsy and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander.
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San Francisco Baking Institute

7.6/10 (423 reviews)
If you'd like to get a taste of South San Francisco student life, check out San Francisco Baking Institute in The East Side. Let yourself be amazed at the art galleries in the area— your cultural tour starts here. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. South San Francisco has other landmarks you might want to visit such as Golden Gate Bridge.
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South San Francisco Hillside Sign

If you're planning a bit of sightseeing head to South San Francisco Hillside Sign— just one of the monuments in Paradise Valley. South San Francisco has other landmarks you might want to visit such as Golden Gate Bridge.
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See's Candies

8.0/10 (474 reviews)
See's Candies is 1.2 mi (2 km) from central South San Francisco, why not stop by during your stay. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. If you have fun at See's Candies, you'll love K1 Speed San Francisco, located nearby.
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K1 Speed San Francisco

7.6/10 (330 reviews)
K1 Speed San Francisco is 1.1 mi (1.7 km) from central South San Francisco, why not stop by during your stay. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. If you have fun at K1 Speed San Francisco, you'll love See's Candies, located nearby.
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Sign Hill Park

If you like quiet time surrounded by flowers and greenery, then make a stop at Sign Hill Park located 8.6 mi (13.8 km) from the center of San Francisco. Want to stretch your legs some more? Head to Bayfront Park and San Bruno Point Park, both nearby.
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Learn more about South San Francisco

Look beyond the iconic 'South San Francisco The Industrial City' sign crowning Sign Hill Park for a city with its own distinct identity. Grand Avenue serves up a global feast of family-run eateries where locals debate the merits of each dumpling house. San Bruno Mountain offers hiking trails with sweeping Bay views that explain why residents tolerate the fog. See's Candies factory tours satisfy sweet tooths, while K1 Speed delivers indoor racing thrills. The Convention Center hosts events that draw visitors who are surprised to discover this isn't simply San Francisco's southern neighborhood. Despite tripling in population since World War II, 'South City' maintains its working-class roots while embracing its role as a Peninsula destination in its own right.

See all hotels in South San Francisco
A coastal cityscape with a prominent bridge, clear blue waters, and a marina.

Check out reviews of South San Francisco hotels guests love

The Marina Inn on San Francisco Bay

The Marina Inn on San Francisco Bay

10/10 Excellent
"Loved everything!"
Sharlyn 1-night trip
Posted 3 hours ago
The Marina Inn on San Francisco Bay
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

8/10 Good
"The location was amazing! The hotel needs some cosmetic repairs but it is clean and everyone was very helpful. The breakfast was delicious."
Brooke 3-night trip
Posted 4 hours ago
Hotel Riu Plaza Fisherman's Wharf
Chancellor Hotel on Union Square

Chancellor Hotel on Union Square

10/10 Excellent
"Nice place. Great location. Very good value."
Benjamin 3-night trip
Posted 9 hours ago
Chancellor Hotel on Union Square
Handlery Union Square Hotel

Handlery Union Square Hotel

8/10 Good
"good"
William Donell 4-night trip
Posted 14 hours ago
Handlery Union Square Hotel
Club Quarters Hotel Embarcadero, San Francisco

Club Quarters Hotel Embarcadero, San Francisco

10/10 Excellent
"Great location with lovely staff!"
Frederick 1-night trip
Posted 1 day ago
Club Quarters Hotel Embarcadero, San Francisco

Frequently asked questions

What accommodations do travelers like in South San Francisco?
Guests like Travelodge by Wyndham San Francisco Airport North, Park Pointe Hotel and DoubleTree by Hilton San Francisco South Airport Blvd.
Can I book refundable accommodations in South San Francisco?
If you need the flexibility to change your travel plans to South San Francisco, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow down the results.
Where can I stay in South San Francisco if I want a vacation rental instead of a hotel?
If you're looking for a good alternative to a hotel, review our selection of 27 vacation homes. In addition, you can choose from 13 apartments.
What will the weather in South San Francisco be like during my visit?
The warmest months in South San Francisco are usually September and August with an average temp of 62°F. February and January are the chilliest months when the average temp is 53°F. The rainiest months are December and January.
Why should I book my South San Francisco accommodation with Hotels.com?
There are lots of reasons to book your South San Francisco trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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