Hotels in Charleston

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Where to stay in Charleston?

A building with a fountain and flower beds in front.

A reception area with a stone wall, wooden cabinets, and a sign for The Riverstone Hotel.

A hotel room with a beige sofa, two patterned armchairs, a ceiling fan, a flat-screen TV, and a window with curtains.

A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.

1. The Riverstone Hotel Charleston-Sikeston

Charleston

$66

$74 total

includes taxes & fees

Sep 13 - Sep 14

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

A reception area with a counter, a flat-screen TV, and a window with blinds.

A reception area with a sofa, a coffee table, a potted plant, and a framed picture on the wall.

2. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

$60

$66 total

includes taxes & fees

Sep 13 - Sep 14

A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

A hotel room with two beds, a nightstand, a lamp, and a window with curtains.

A bathroom with a sink, mirror, towel rack, shower, and toilet.

A motel with a sign reading "Eagle Inn" and a parking lot with several cars.

3. Eagle Inn Charleston

Charleston

$77

$85 total

includes taxes & fees

Sep 12 - Sep 13

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

4. Drury Inn & Suites Sikeston, MO

Sikeston

$102

$117 total

includes taxes & fees

Sep 17 - Sep 18

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.

A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.

5. Best Western Plus Sikeston I-55

Sikeston

$87

$99 total

includes taxes & fees

Sep 20 - Sep 21

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

An indoor swimming pool with a tiled floor, a lifeguard chair, and a pool ladder.

A reception area with a reception desk, a large wall-mounted sign, and a potted plant.

A buffet with various food items, including omelets and baked goods, served in metal containers.

6. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

$98

$111 total

includes taxes & fees

Oct 11 - Oct 12

A hotel lobby with a reception desk, seating area, and a large window.

A hotel lobby with a reception desk, two armchairs, a coffee table, and large windows with potted plants.

A Quality Inn hotel with a green sign, a covered outdoor area, and a parking lot.

A hotel room with two beds, a desk with a computer, a television, and a window with curtains.

7. Quality Inn Cairo I-57

Cairo

$70

$78 total

includes taxes & fees

Oct 2 - Oct 3

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

8. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

$101

$114 total

includes taxes & fees

Sep 17 - Sep 18

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A Travel Inn and Suites building with a prominent illuminated sign, a brick facade, and a parking lot.

A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.

A reception area with a sign for 'Travel Inn and Suites'.

9. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

$69

$79 total

includes taxes & fees

Sep 13 - Sep 14

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

A spacious lobby with a central atrium, a piano, and a reception desk.

A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.

10. Days Inn and Suites by Wyndham Sikeston

Sikeston

$65

$75 total

includes taxes & fees

Sep 13 - Sep 14

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a painting on the wall.

A bathroom with yellow walls, a wooden cabinet, a sink, a mirror, and a hanging towel rack.

A motel with a red roof and beige walls, a parking lot, and a signboard.

A reception desk with a computer, a framed picture on the wall, and a vase with flowers.

11. La Center Motel

La Center

$54

$63 total

includes taxes & fees

Sep 20 - Sep 21

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

12. Hampton Inn Sikeston

Sikeston

$102

$115 total

includes taxes & fees

Oct 11 - Oct 12

A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

A hotel lobby with a reception desk, seating area, and large windows offering a view of the outdoors.

A living room with two sofas, a coffee table, a TV, and a cabinet.

A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.

13. Comfort Inn & Suites Sikeston I-55

Sikeston

$89

$101 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A hotel room with two beds, a sofa, a coffee table, and artwork on the walls.

A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.

A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

14. Super 8 by Wyndham Sikeston/Miner Area

Sikeston

$57

$65 total

includes taxes & fees

Sep 20 - Sep 21

A modern kitchen with white cabinetry, stainless steel appliances, and a window with a view of greenery.

A kitchen with white cabinets, a stainless steel refrigerator, a coffee maker, and a trash can.

A small, single-story house with a front porch and a gravel driveway.

A living room with a gray sofa, a patterned rug, wooden flooring, a ceiling fan, a wall-mounted lamp, and a framed picture.

15. Quiet Country Stay: Modern Home Near Paducah

Cunningham

$149

$290 total

includes taxes & fees

Sep 28 - Sep 29

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

A reception area with a counter, a coffee machine, and seating.

A bathroom with a bathtub, toilet, and shower curtain.

A motel with a blue awning and a green 7-Eleven. It has a covered parking area and a two-story structure with a balcony.

16. Country Yard Inn and Suite

Sikeston

$59

$71 total

includes taxes & fees

Sep 16 - Sep 17

A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.

A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.

An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

17. TownePlace Suites by Marriott Sikeston

Sikeston

$109

$123 total

includes taxes & fees

Oct 11 - Oct 12

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

18. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

$100

$113 total

includes taxes & fees

Sep 20 - Sep 21

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern outdoor seating area with a glass-top table and a fire feature, overlooking a sunset view.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

19. The Riverview

Cape Girardeau

$114

$129 total

includes taxes & fees

Sep 13 - Sep 14

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

20. Pear Tree Inn Cape Girardeau West

Cape Girardeau

$72

$81 total

includes taxes & fees

Sep 20 - Sep 21

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Go beyond your typical stay in Charleston

Pet friendly

Pool

Family friendly

Our prices for hotels in Charleston are cheapest in January

Learn more about Charleston

Charleston is well-known for its attractions such as Mississippi River and Ohio River. Visitors give high marks to the city's restaurants and small-town setting.

See all hotels in Charleston

A sunset over a calm lake with tall trees reflected in the water.

Check out reviews of Charleston hotels guests love

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"All good, staff friendly and helpful! Breakfast was great and kick back dinner was good!"

The Riverview

10/10 Excellent

"Very clean They need a fitness center !"

Fairfield Inn & Suites by Marriott Cape Girardeau

10/10 Excellent

"The receptionist was very courteous. Helped answer all my questions. We loved the room. And we had a great breakfast before we left."

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent

"We had no problem checking in. The room was nice and clean. The staff were courteous and helpful. Parking was acceptable. Close to our room. No complaints."

Hampton Inn Sikeston

10/10 Excellent

"Really quiet place close to good restaurants and stores."

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"."

The Riverstone Hotel Charleston-Sikeston

10/10 Excellent

"Everything was fine for a one night stay."

Best Western Plus Sikeston I-55

8/10 Good

"Great location, nice, clean and well maintained, Hotel employees were very helpful great customer service,"

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good

"For a older hotel. It was pleasant. Very good staff"

Frequently asked questions

What hotels do travelers recommend in Charleston?

Guests like Super 8 by Wyndham Charleston/Sikeston East MO, The Riverstone Hotel Charleston-Sikeston and Eagle Inn Charleston.

Can I book a refundable accommodation in Charleston?

If you're looking for the flexibility to change your plans to Charleston, most accommodations offer refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.

Where should I consider staying in Charleston if I'm looking for a cheap accommodation?

An inexpensive option worth considering is The Riverstone Hotel Charleston-Sikeston.

What will the weather in Charleston be like during my vacation?

July and August are typically the warmest months in Charleston when the average temp is 77°F. January and February are the coldest months when the average temperature is 41°F. April and March are the months with the most rain.

Why should I book my Charleston accommodation with Hotels.com?

There are lots of reasons to book your Charleston trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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Book Hotels in Charleston on Hotels.com

Hotels in Charleston

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Where to stay in Charleston?

1. The Riverstone Hotel Charleston-Sikeston

2. Super 8 by Wyndham Charleston/Sikeston East MO

3. Eagle Inn Charleston

4. Drury Inn & Suites Sikeston, MO

5. Best Western Plus Sikeston I-55

6. Holiday Inn Express & Suites Sikeston Southwest by IHG

7. Quality Inn Cairo I-57

8. Fairfield Inn & Suites by Marriott Sikeston

9. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10. Days Inn and Suites by Wyndham Sikeston

11. La Center Motel

12. Hampton Inn Sikeston

13. Comfort Inn & Suites Sikeston I-55

14. Super 8 by Wyndham Sikeston/Miner Area

15. Quiet Country Stay: Modern Home Near Paducah

16. Country Yard Inn and Suite

17. TownePlace Suites by Marriott Sikeston

18. Drury Plaza Hotel Cape Girardeau Conference Center

19. The Riverview

20. Pear Tree Inn Cape Girardeau West

Go beyond your typical stay in Charleston

Price trends for hotels in Charleston

Typical weather for Charleston

Learn more about Charleston

Check out reviews of Charleston hotels guests love

Drury Inn & Suites Sikeston, MO

The Riverview

Fairfield Inn & Suites by Marriott Cape Girardeau

Super 8 by Wyndham Sikeston/Miner Area

Hampton Inn Sikeston

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

The Riverstone Hotel Charleston-Sikeston

Best Western Plus Sikeston I-55

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Frequently asked questions

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