Hotels in Mesopotamia

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Check prices for these dates

Next weekend
Aug 7 - Aug 9
In two weeks
Aug 14 - Aug 16

Top 5 hotels in Mesopotamia at a glance

  1. To Spiti tis Sofias — Located in Kastoria. Guest rating: 10/10 — Exceptional.
  2. Hotel Anastassiou — 2-star hotel in Kastoria. Guest rating: 8.0/10 — Very Good.
  3. Chloe Hotel — 3-star hotel in Kastoria. Guest rating: 10/10 — Exceptional.
  4. Guest House Ilektra — Located in Voio. Guest rating: 9.8/10 — Exceptional.
  5. Esperos Palace Luxury & Spa Hotel — 4-star hotel in Kastoria. Guest rating: 9.0/10 — Wonderful.

Where to stay in Mesopotamia?

Interior

To Spiti tis Sofias

To Spiti tis Sofias
Kastoria
10.0 out of 10, Exceptional, (1 review)
Experience tranquil accommodations at this guesthouse near Kastoria Lake and the Aquarium. Complimentary WiFi and parking simplify your stay, while daily housekeeping ensures comfort during your exploration of this beautiful Greek destination.
The price is $66
$77 total
includes taxes & fees
Aug 30 - Aug 31
To Spiti tis Sofias
Front of property - evening/night

Hotel Anastassiou

Hotel Anastassiou
2.0 star property
Kastoria
8.0 out of 10, Very Good, (70 reviews)
The price is $46
$54 total
includes taxes & fees
Aug 30 - Aug 31
Hotel Anastassiou
Terrace/patio

Chloe Hotel

Chloe Hotel
3.0 star property
Kastoria
10.0 out of 10, Exceptional, (89 reviews)
Unwind at this Kastoria hotel, near Byzantine and Folklore museums. Enjoy free breakfast, parking, and WiFi after a day of tennis, wine tasting at the onsite winery, or rejuvenating spa treatments at this Mediterranean retreat.
The price is $102
$121 total
includes taxes & fees
Aug 30 - Aug 31
Chloe Hotel
Exterior

Guest House Ilektra

Guest House Ilektra
Voio
9.8 out of 10, Exceptional, (11 reviews)
This tranquil retreat in Voio offers a restaurant for traditional flavors and a bar for evening relaxation. Wander through the garden or unwind on the terrace after exploring the region. Free WiFi and parking make your stay convenient.
The price is $61
$71 total
includes taxes & fees
Sep 1 - Sep 2
Guest House Ilektra
Indoor pool

Esperos Palace Luxury & Spa Hotel

Esperos Palace Luxury & Spa Hotel
4.0 star property
Kastoria
9.0 out of 10, Wonderful, (84 reviews)
The price is $106
$132 total
includes taxes & fees
Aug 9 - Aug 10
Esperos Palace Luxury & Spa Hotel
Terrace/patio

Orologopoulos Mansion

Orologopoulos Mansion
5.0 star property
Kastoria
9.6 out of 10, Exceptional, (37 reviews)
Unwind in this luxurious hotel near Museum of the Macedonian Struggle featuring free breakfast, WiFi, and airport shuttle. Enjoy hiking trails, relax at the bar/lounge, or sip drinks on the terrace after exploring Kastoria's cultural landmarks.
The price is $124
$158 total
includes taxes & fees
Aug 9 - Aug 10
Orologopoulos Mansion
Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds

Kyknos De Luxe Hotel

Kyknos De Luxe Hotel
Kastoria
10.0 out of 10, Exceptional, (43 reviews)
Discover this luxury hotel with free WiFi and self parking near Kastoria's cultural attractions. Explore the Folklore Museum and Byzantine Museum, then return to comfort with 24-hour front desk service just 20 minutes from Aristoteles Airport.
The price is $86
$100 total
includes taxes & fees
Aug 31 - Sep 1
Kyknos De Luxe Hotel
Property grounds

Calma Hotel & Spa

Calma Hotel & Spa
4.0 star property
Kastoria
9.6 out of 10, Exceptional, (37 reviews)
The price is $101
$126 total
includes taxes & fees
Aug 29 - Aug 30
Calma Hotel & Spa
Restaurant

Guesthouse Vissinokipos

Guesthouse Vissinokipos
Kastoria
9.4 out of 10, Exceptional, (10 reviews)
Tucked within Kastoria, this inviting guesthouse offers free breakfast, WiFi, and parking. Sip evening drinks at the bar/lounge, enjoy garden relaxation, or visit the nearby Byzantine and Folklore Museums for local culture.
The price is $73
$85 total
includes taxes & fees
Aug 30 - Aug 31
Guesthouse Vissinokipos
Property grounds

Anesis Hotel

Anesis Hotel
2.0 star property
Kastoria
9.0 out of 10, Wonderful, (9 reviews)
The price is $56
$66 total
includes taxes & fees
Aug 11 - Aug 12
Anesis Hotel
Exterior

Andromeda Boutique hotel

Andromeda Boutique hotel
4.0 star property
Kastoria
8.8 out of 10, Excellent, (3 reviews)
The price is $68
$100 total
includes taxes & fees
Aug 30 - Aug 31
Andromeda Boutique hotel
Outdoor dining

OIKOI - Luxury Suites & Maisonettes

OIKOI - Luxury Suites & Maisonettes
Kastoria
The price is $100
$139 total
includes taxes & fees
Aug 9 - Aug 10
OIKOI - Luxury Suites & Maisonettes
Apartment | Interior

Lūma Retreat

Lūma Retreat
Kastoria
The price is $74
$86 total
includes taxes & fees
Aug 4 - Aug 5
Lūma Retreat
Lunch and dinner served

Guesthouse Monopati

Guesthouse Monopati
Amyntaio
10.0 out of 10, Exceptional, (3 reviews)
Nestled in Amyntaio, this guesthouse offers free breakfast and WiFi, with Monopati restaurant serving lunch and dinner on-site. Explore nearby Moni Panagias Monastery and Arcturos Bear Sanctuary, then return to comfortable rooms with daily housekeeping service.
The price is $74
$86 total
includes taxes & fees
Aug 31 - Sep 1
Guesthouse Monopati
Exterior

Arhontiko Christodoulou

Arhontiko Christodoulou
2.0 star property
Prespes
Escape to this idyllic hotel near Prespa National Park, where apartments feature fireplaces, kitchenettes, and furnished balconies. Enjoy complimentary breakfast each morning before exploring hiking trails, then return for free WiFi and parking.
The price is $73
$85 total
includes taxes & fees
Aug 30 - Aug 31
Arhontiko Christodoulou
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Check out reviews of Mesopotamia hotels guests love

Orologopoulos Mansion

Orologopoulos Mansion

10/10 Excellent
"This is the hotel we return to time and time again, and the one we are never disappointed by. * Clean: Perfectly clean. Daily refresh of linens and tidying of room. Public spaces pristine. Black out shades were a pleasant surprise in an antique building like this one. Loved that touch! * Customer service. Top-tier service. Warm and friendly but also give space. * Breakfast. Delicious pites, pastries, yogurt. Choice of barista-quality coffees. Lovely space to eat, both inside and outside in their private garden. * Location. One block from the lake (GREAT for jogging) and across the street from the plateia (square), with its choice of chic restaurants. Quiet when you need it to be. * Parking. Right in front every day, with no issue whatsoever. Always a perfect stay. Love this hotel!"
Paula 3-night trip
Posted 2 weeks ago
Orologopoulos Mansion

Frequently asked questions

What hotels do travelers like in Mesopotamia?
Guests like To Spiti tis Sofias, Limneon Resort & Spa and Esperos Palace Luxury & Spa Hotel.
Can I book a refundable hotel in Mesopotamia?
If you want the flexibility to change your travel plans to Mesopotamia, most hotels offer refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in Mesopotamia be like during my trip?
The warmest months in Mesopotamia are usually August and July with an average temp of 69°F. January and February are the chilliest months when the average temp is 37°F. The rainiest months are November and December.
Why should I book my Mesopotamia hotel with Hotels.com?
There are plenty of reasons to book your Mesopotamia travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.