Hotels in Santa Ana

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Top 5 hotels in Santa Ana at a glance

Casco View Apartments — 3.5-star hotel in Santa Ana. Guest rating: 9.0/10 — Wonderful.
Hostal La Cigarra — 2-star hotel in Santa Ana. Guest rating: 7.6/10 — Good.
Hotel Caracas - Casco Viejo — 3-star hotel in Santa Ana. Guest rating: 7.6/10 — Good.
ART CASCO The Hotel — 2-star hotel in Santa Ana. Guest rating: 6.2/10.
Hotel República — 2-star hotel in Santa Ana. Guest rating: 6.8/10.

Where to stay in Santa Ana?

A modern indoor pool area with clear blue water, lounge chairs, and a wall of plants.

A modern kitchen with a large window, a dining area with chairs, and a view of the city.

A modern kitchen with a central island, stainless steel appliances, and a dining area with black chairs.

A balcony with a view of the sea, a table with a vase and a candle, and a chair.

Casco View Apartments

Santa Ana

melvin

$65

$101 total

includes taxes & fees

Aug 26 - Aug 27

A restaurant with a long counter, chairs, and tables. There are plants and lights decorating the space.

A living room with wicker furniture, a yellow sofa, and a bookshelf.

A hotel lobby with a map of the Caribbean, a fan, and a table with snacks and a flower vase.

A hallway with a wooden door marked '14', a window, and a staircase with a railing.

Hostal La Cigarra

Santa Ana

Mark

$31

$34 total

includes taxes & fees

Aug 26 - Aug 27

Hotel Caracas - Casco Viejo

Santa Ana

William

$35

$38 total

includes taxes & fees

Sep 21 - Sep 22

A hotel entrance with a green facade and a metal fence.

A spacious living area with a staircase, a dining table, and a television.

A living room with a television on a stand, a Christmas tree, and a small table with two chairs.

A neatly made bed with a teal bedspread, two pillows, and two towels folded at the foot of the bed. There is a wooden nightstand with a phone and a small table beside the bed.

ART CASCO The Hotel

Santa Ana

Eldris

$25

$27 total

includes taxes & fees

Aug 29 - Aug 30

A hotel room with a large bed, a window with curtains, a city view, and a lamp.

A balcony with a city view, featuring a curved railing and a palm tree.

A corridor with tiled flooring, doors, and a fire extinguisher mounted on the wall.

A multi-story building with a flat facade, multiple balconies, and a sign indicating it is a public building.

Hotel República

Santa Ana

Danilo

$29

$92 total

includes taxes & fees

Aug 26 - Aug 27

A modern hotel room with a large bed, a sofa, a TV, and a view of the city.

A modern hotel room with a large bed, a wooden headboard, a hanging plant, and a view of the kitchen area.

A spacious living area with wicker furniture, a glass coffee table, and large windows providing natural light.

A modern kitchen with a bar area, green bar stools, a stainless steel refrigerator, and a patterned floor.

La Manzana Barrio Vivo by Wynwood

Santa Ana

Javier Alberto Lindauer

$78

$114 total

includes taxes & fees

Aug 26 - Aug 27

A bar area with a curved counter, multiple seating options, and a variety of bottles and glasses on display.

A hotel room with two beds, a bathroom, and a shower area.

A teal wall-mounted rack with multiple circular slots, likely for hanging items.

Hotel Riazor

Santa Ana

Del

$27

$30 total

includes taxes & fees

Aug 26 - Aug 27

A high-rise building with a glass balcony overlooking a city skyline and a body of water.

A high-rise building with a grid of windows and balconies.

A modern dining area with grey sofas and blue chairs, large windows offering a view of the sea and cityscape.

Room-sofa Bed Stay Rooftop Pool & Gym, A

Santa Ana

Cristian Camilo Betancur

$104

$115 total

includes taxes & fees

Sep 25 - Sep 26

A wooden door with a number plate, a black and white striped bag, and a lantern on the ground.

A rooftop bar with potted plants, seating, and a view of a city skyline.

A restaurant with a wine display and a table set for two.

A rooftop terrace with a city skyline view, a pool, and outdoor seating.

Hotel Casa Panamá

San Felipe, 0.6 km from Santa Ana

Liza

$61

$67 total

includes taxes & fees

Sep 24 - Sep 25

A spacious living room with blue sofas, a marble coffee table, and framed pictures on the walls.

A bedroom with a large bed, white walls, and a view of a building through arched windows.

A blue building with arched windows and balconies, labeled 'Magnolia.'

Hotel Magnolia Boutique

San Felipe, 0.7 km from Santa Ana

Sharon

$73

$80 total

includes taxes & fees

Aug 26 - Aug 27

A multi-story building with balconies, arched windows, and decorative railings.

A spacious lobby with a wooden staircase, multiple seating areas, and a reception desk.

A multi-level atrium with wooden staircases, seating areas, and a decorative ceiling.

A building with a balcony and a street view.

Central Hotel Panama Casco Viejo

San Felipe, 0.9 km from Santa Ana

Dana

$183

$202 total

includes taxes & fees

Sep 22 - Sep 23

A rooftop bar with a city skyline view, outdoor seating, and a bar area with bottles and glasses.

A room with a kitchenette, a sofa, a bed, and a mural with the phrase "Just Breathe".

A modern living room with a purple wall, two abstract paintings, a white sofa with colorful cushions, a wooden coffee table with books and bottles, and patterned floor tiles.

A hotel room with a large bed, a painting on the wall, a door, and a small table with a lamp.

Tantalo Hotel

San Felipe, 0.7 km from Santa Ana

SUSAN

$93

$103 total

includes taxes & fees

Sep 6 - Sep 7

A balcony with a view of a cityscape, including a river and a bridge.

A bedroom with a sloped ceiling, a bed with white bedding, a small wooden drying rack, a patterned rug, and an air conditioning unit.

A spacious living area with a patterned rug, a round ottoman, a sofa, and a coffee table. There is a door leading to another room and a wall-mounted security camera.

A living room with a sofa, coffee table, TV, and artwork on the walls.

Oasis Hotel

San Felipe, 0.6 km from Santa Ana

MARGARET

$59

$65 total

includes taxes & fees

Sep 1 - Sep 2

A rooftop pool area with lounge chairs and a bar, overlooking a city skyline at sunset.

A spacious lobby with high ceilings, large windows, and modern lighting fixtures.

A modern hotel lobby with a glass railing, seating area, and contemporary lighting fixtures.

A buffet setup with various dishes and utensils.

Marriott Panama Hotel

2.1 km from Santa Ana

Sonya Allende

$161

$177 total

includes taxes & fees

Sep 4 - Sep 5

A balcony with a table, chairs, and a view of a city skyline across a body of water.

A spacious living room with a high ceiling, large windows, and a decorative ceiling fan.

A spacious lobby with high ceilings, modern furniture, and decorative lighting fixtures.

A spacious lobby with a round coffee table, seating areas, and a large wall clock.

Sofitel Legend Casco Viejo, Panama City

San Felipe, 1.1 km from Santa Ana

Lisa

$342

$376 total

includes taxes & fees

Sep 8 - Sep 9

A resort with a pool area, lounge chairs, and a view of a bridge at night.

A modern living room with a sofa, chairs, a coffee table, and a staircase leading to a balcony.

A restaurant with a modern interior, featuring black and white patterned chairs, wooden tables, hanging pendant lights, and a menu board on the wall.

A balcony with two wooden chairs, a white balustrade, and a view of boats and palm trees on a calm sea.

Radisson Hotel Panama Canal

Amador, 2.3 km from Santa Ana

Maxima

$94

$104 total

includes taxes & fees

Aug 26 - Aug 27

A spacious outdoor patio with wicker furniture, potted plants, and umbrellas providing shade.

A modern bar area with wooden bar stools, a black countertop, and a display of wine bottles.

A modern hotel lobby with beige sofas, marble flooring, and a reception desk.

A dimly lit restaurant with wooden decor, tables, and chairs arranged for dining.

Hotel San Felipe

San Felipe, 0.7 km from Santa Ana

Helle

$165

$182 total

includes taxes & fees

Aug 29 - Aug 30

A spacious indoor area with high ceilings, large windows, and multiple dining tables.

A spacious lobby with a tiled floor, large windows, and potted plants.

A white building with multiple balconies, large windows, and decorative railings.

A restaurant with brick walls, arched windows, and a variety of seating arrangements including tables and chairs.

American Trade Hotel

San Felipe, 0.7 km from Santa Ana

iriela

$246

$270 total

includes taxes & fees

Sep 1 - Sep 2

A restaurant with multiple dining tables, chairs, and a central water feature.

A bar area with multiple seating options, a bar counter, and a fireplace.

A rooftop terrace with tables and chairs, a view of two white towers, and a building with a large window.

A modern living room with a sofa, a coffee table, and a TV mounted on the wall.

Hotel La Compañía Casco Antiguo

San Felipe, 0.9 km from Santa Ana

Michael

$318

$350 total

includes taxes & fees

Sep 17 - Sep 18

A rooftop pool area with lounge chairs and a table, overlooking a city skyline and the ocean.

A hotel entrance with a glass door, metal staircase, and green lighting.

A dining table with a plate of food, a glass of water, and a vase with flowers.

A hotel room with a bed adorned with rose petals, a desk, a chair, and red balloons.

Hotel Caribe

Calidonia, 1.2 km from Santa Ana

Yira

$42

$46 total

includes taxes & fees

Aug 31 - Sep 1

View all properties

Compare popular hotels in Santa Ana

Property	Property class	Guest rating
Casco View Apartments	9.0 Wonderful 105 reviews	View
Hostal La Cigarra	7.6 Good 73 reviews	View
Hotel Riazor	3.8 11 reviews	View
Hotel Caracas - Casco Viejo	7.6 Good 4 reviews	View
Hotel República	6.8 196 reviews	View

Our prices for hotels in Santa Ana are cheapest in February

Top landmarks in Santa Ana

El Machetazo Santa Ana

If you want to give your credit card some exercise, head out to El Machetazo Santa Ana in Santa Ana. Splash some more cash at Avenida Central and Paseo de Las Bovedas.

See properties

Check out reviews of Santa Ana hotels guests love

Decapolis Hotel Panama City

8/10 Good

"The property is clean, my room was spacious and the staffs are friendly and helpful. I definitely going stay in this hotel again."

Hotel Riu Plaza Panama

10/10 Excellent

"Perfect stay for a few day in Panama, close popular fast food restaurant, grocery, malls & airport."

Courtyard by Marriott Panama Metromall

10/10 Excellent

"Room was spotless and staff were friendly and willing to help. Even booked us a taxi to the airport."

Aloft by Marriott Panama

10/10 Excellent

"This is a well located hotel close to the biggest shopping mall in Panama’ City. The staff is very kind and friendly. The breakfast has a lot of options with fresh food and good buffet. We stayed four days before to return to the USA and Panamá has very kind people. We recommend this place."

Central Hotel Panama Casco Viejo

10/10 Excellent

"Lovely"

Hyatt Regency Panama City

10/10 Excellent

"I absolutely love Hyatt, all their hotels match the vibe and energy of the country they're in and this location was no different! The hotel was beautifully decorated and peaceful. The coffee at Amado was great, I started my morning there each day. The drinks at Rulfo were also wonderful. The staff were kind and attentive, they provided umbrellas for us to use one afternoon when it was pouring rain. Room service also came quickly when we ordered. The housekeeping staff also did a great job with refreshing the rooms each day. Another highlight that I can't forget to mention is the gym, wow! The gym was two levels, complete with a sauna, a great assortment of weight lifting machines and equipment and Pelatons - honestly the best chain hotel gym I have ever seen. Overall this hotel comes highly recommended."

Waldorf Astoria Panama

10/10 Excellent

"Wonderful place to stay"

Courtyard by Marriott Panama Multiplaza Mall

10/10 Excellent

"I live in Panama so when I travel back to the US, I always stay the night before here. 1st class place. Easy shuttle and the employees are the best. I only stay here when I travel. Food is great as well, rooms are clean and comfortable."

Renaissance Panama City Hotel

10/10 Excellent

"Great hotel"

Find out more about Santa Ana

Hotels in Santa Ana

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Top 5 hotels in Santa Ana at a glance

Where to stay in Santa Ana?

Casco View Apartments

Hostal La Cigarra

Hotel Caracas - Casco Viejo

ART CASCO The Hotel

Hotel República

La Manzana Barrio Vivo by Wynwood

Hotel Riazor

Room-sofa Bed Stay Rooftop Pool & Gym, A

Hotel Casa Panamá

Hotel Magnolia Boutique

Central Hotel Panama Casco Viejo

Tantalo Hotel

Oasis Hotel

Marriott Panama Hotel

Sofitel Legend Casco Viejo, Panama City

Radisson Hotel Panama Canal

Hotel San Felipe

American Trade Hotel

Hotel La Compañía Casco Antiguo

Hotel Caribe

Compare popular hotels in Santa Ana

Price trends for hotels in Santa Ana

Typical weather for Panama City

Top landmarks in Santa Ana

El Machetazo Santa Ana

Check out reviews of Santa Ana hotels guests love

Decapolis Hotel Panama City

Hotel Riu Plaza Panama

Courtyard by Marriott Panama Metromall

Aloft by Marriott Panama

Central Hotel Panama Casco Viejo

Hyatt Regency Panama City

Waldorf Astoria Panama

Courtyard by Marriott Panama Multiplaza Mall

Renaissance Panama City Hotel