Top 10 Hotels in Puxico, MO in 2026 (from $50)

A night scene with a clear sky, a crescent moon, and two silhouetted trees against a twilight sky.

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Where to stay in Puxico?

A coffee shop with a coffee machine, espresso cups, a sink, and a trash bin.

A hotel room with two beds, a desk with a lamp, a chair, a dresser, and a door with a handle.

A kitchen with a white microwave, a fruit basket, a coffee maker, and a storage container.

A hotel hallway with patterned carpet, light green walls, and a ceiling with recessed lighting.

1. Dexter Inn

Dexter

$69

$77 total

includes taxes & fees

Sep 26 - Sep 27

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

2. Hampton Inn Poplar Bluff

Poplar Bluff

$88

$98 total

includes taxes & fees

Oct 18 - Oct 19

A modern hotel lobby with a bar area, seating, and artwork on the walls.

A swimming pool with clear blue water, surrounded by sun loungers and a lifeguard stand.

A modern hotel with a prominent sign, a covered entrance, and a well-lit exterior.

A modern kitchen with a large island, bar stools, wine bottles, and a built-in TV.

3. Hampton Inn By Hilton Dexter

Dexter

$98

$110 total

includes taxes & fees

Oct 4 - Oct 5

A rustic cabin with a metal roof, surrounded by a wooden deck and picnic tables, set in a forested area.

A bedroom with a wooden bed, a bench, and a window.

A wooden deck with a railing leading to a building with a metal roof and a brown door.

4. Lake Wappapello

Williamsville

$100

$105 total

includes taxes & fees

Sep 26 - Sep 27

A spacious lobby with a reception desk, seating area, and large windows.

A hotel room with a bed, a desk, a chair, a sofa, and a TV.

A spacious conference room with brick walls, multiple tables and chairs, a large window, and a mounted TV.

An indoor swimming pool with a clear view of the outside through large windows.

5. Drury Inn & Suites Poplar Bluff

Poplar Bluff

$94

$106 total

includes taxes & fees

Oct 18 - Oct 19

A hotel room with a sofa, a small table, a chair, a desk, two lamps, a window with curtains, and a framed picture on the wall.

A modern lobby with a curved sectional sofa, a glass coffee table, and two armchairs.

A hotel room with a desk, chair, and a small seating area. It includes a microwave, coffee maker, and a refrigerator.

6. Holiday Inn Poplar Bluff by IHG

Poplar Bluff

$83

$94 total

includes taxes & fees

Oct 25 - Oct 26

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

A corner market with a refrigerated display case and a pantry area.

An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

A reception area with a wooden counter, a coffee machine, and a display of pastries.

7. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

$101

$114 total

includes taxes & fees

Oct 4 - Oct 5

A diner with booth seating, a checkered floor, and a counter with a cash register.

A gym with multiple exercise machines, a clock on the wall, and a window with blinds.

A hotel room with a bed, a desk, a chair, a large mirror, a sink, and a trash bin.

A reception area with a marble counter, potted plants, a clock, and a TV on the wall.

8. Travelodge by Wyndham Dexter

Dexter

$95

$107 total

includes taxes & fees

Oct 8 - Oct 9

A hotel room with a bed, a desk, a chair, a bathroom with a bathtub, and a patterned floor.

A living room with a sofa, a coffee table, a clock, and a painting on the wall.

A kitchen with wooden cabinets, a stainless steel sink, a microwave, and a dishwasher.

A hotel reception area with a reception desk, framed certificates, and a painting on the wall.

9. Econo Lodge Dexter

Dexter

$51

$57 total

includes taxes & fees

Oct 24 - Oct 25

A hotel room with two beds, a TV, a mirror, a wardrobe, and a desk.

A window with a view of a parking lot and buildings, a welcome sign, and a credit card machine.

A Hickory House Inn with a clear sky, a parking lot, and a covered entrance.

A row of single-story brick buildings with attached garages, likely a motel or small hotel, with a parking lot in front and a grassy area with a gazebo.

10. OYO Hickory House Inn

Dexter

$67

$81 total

includes taxes & fees

Oct 24 - Oct 25

A modern kitchen with a coffee machine, a sink, and a counter. There are four chairs and a table in the dining area.

A hotel room with two beds, a desk, a chair, a TV mounted on the wall, and a mirror.

A compact kitchen with a dark wooden desk, a black refrigerator, a microwave, and a coffee maker.

A hotel reception area with a modern design, featuring a reception desk, a glass door, and a wall with framed pictures and a large number '6' sign.

11. Motel 6 Poplar Bluff, MO

Poplar Bluff

$74

$83 total

includes taxes & fees

Sep 27 - Sep 28

A hotel lobby with a reception desk, a blue sofa, a fireplace, and a television.

A hotel room with a bed, two armchairs, a sofa, a small table, a TV, a ceiling fan, and a window with curtains.

A hotel room with a bed, a sofa, a small table, and a painting on the wall.

A hotel with a covered entrance, multiple windows, and a yellow facade.

12. Comfort Inn Poplar Bluff North

Poplar Bluff

$83

$94 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with a bed, two bedside lamps, a framed picture of a building, and a nightstand with a phone.

A two-story motel with a covered parking area and a bench outside.

A self-service breakfast area with a refrigerated drink cooler, a coffee machine, and various food items on the counter.

A laundry area with two stacked washers and dryers, a control panel, and a beige wall with a wooden panel above the dryers.

13. Super 8 by Wyndham Poplar Bluff Missouri

Poplar Bluff

$55

$62 total

includes taxes & fees

Oct 15 - Oct 16

A living room with a blue wall, a fireplace, a sofa, and a chair.

A hotel room with two beds, a vanity with a mirror, a chair, and a dresser.

A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.

A bar area with stools and a counter where a bartender is serving drinks.

14. EC Reed's Mercantile and Hotel

Marble Hill

$105

$114 total

includes taxes & fees

Oct 5 - Oct 6

A spacious living area with a dark grey sofa set, a matching ottoman, and a wooden-paneled wall.

A house with a red door, a porch with rocking chairs, and a wreath on the door.

A room with wooden paneling, a ceiling fan, a dining table with chairs, and a sofa.

A spacious dining area with a stone wall, wooden furniture, and a fireplace.

15. 40-acre Poplar Bluff Nature Lovers Paradise!

Poplar Bluff

$120

$297 total

includes taxes & fees

Oct 7 - Oct 8

View all properties

Go beyond your typical stay in Puxico

Learn more about Puxico

Puxico is well-known for its attractions such as Mark Twain National Forest and Mingo Wilderness.

See all hotels in Puxico

Check out reviews of Puxico hotels guests love

Lake Wappapello

Williamsville

10/10 Exceptional

This a cabin in a state park. It was very clean and had newer upgrades. Bring the food you need because it's fairly distance from a grocery. We came later in the day because we needed one night and this was a great price and not a chain hotel which we like. There is a little store not too far from the park. We ordered deli sandwiches from here and picked up some icecream. The sandwiches were delicious and the store had pretty much whatever you might need. The checkin process was great with good...

Dottie

Hampton Inn Poplar Bluff

Poplar Bluff

10/10 Exceptional

Ken

Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

10/10 Exceptional

Anonymous traveler

Holiday Inn Poplar Bluff by IHG

Poplar Bluff

10/10 Exceptional

Luis

Motel 6 Poplar Bluff, MO

Poplar Bluff

10/10 Exceptional

Sandra

Comfort Inn Poplar Bluff North

Poplar Bluff

10/10 Exceptional

Linda

40-acre Poplar Bluff Nature Lovers Paradise!

Poplar Bluff

10/10 Exceptional

Anonymous traveler

Frequently Asked Questions

What hotels do travelers like in Puxico?

Guests like 'the Lakehouse' Lovely Wappapello Country Home!.

Can I book a refundable accommodation in Puxico?

If you want the flexibility to change your travel plans to Puxico, most accommodations provide refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in Puxico be like during my visit?

The warmest months in Puxico are usually July and August with an average temp of 77°F. January and February are the chilliest months when the average temp is 41°F. The rainiest months are April and May.

Why should I book my Puxico hotel through Hotels.com?

There are plenty of reasons to book your Puxico travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.