Quality Inn Cairo I-57 offers a warm welcome with full breakfast and free in-room WiFi. Relax by the seasonal outdoor pool or unwind in the lobby with coffee/tea and newspapers. Guests appreciate the helpful 24-hour front desk staff.
Mound City National Cemetery - 7 min drive - 10.4 km
Fort Defiance State Park - 10 min drive - 9.5 km
Ullin City Hall - 18 min drive - 38.9 km
City of Miner Convention Center - 22 min drive - 50.4 km
Sikeston Depot Museum - 27 min drive - 57.3 km
Getting around
Cairo, IL (CIR-Cairo Regional) - 5 min drive
Paducah, KY (PAH-Barkley Regional) - 43 min drive
Cape Girardeau, MO (CGI-Cape Girardeau Municipal) - 43 min drive
Restaurants
Shemwells BBQ - 7 min drive
Nu Diner - 8 min drive
Spirit House Beer Garden - 8 min drive
Sneed's Cafe - 17 min walk
Shemwell's Bar-B-Q - 7 min drive
About this property
Quality Inn Cairo I-57
When you stay at Quality Inn Cairo I-57, you'll be within a 15-minute drive of Mississippi River. Free perks include WiFi, self parking, and full breakfast daily between 6 AM and 10 AM.
At a glance
DONE
Hotel size
38 rooms
Arranged over 2 floors
DONE
Arriving/Leaving
Check-in start time: 3 PM; Check-in end time: 3:30 AM
Early check-in subject to availability
Late check-in subject to availability
Minimum check-in age: 18
Check-out time is 11 AM
Late check-out subject to availability
DONE
Special check-in instructions
Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools
DONE
Required at check-in
Credit card, debit card, or cash deposit required for incidental charges
Government-issued photo ID may be required
Minimum check-in age is 18
DONE
Children
Children (18 years old and younger) stay free when occupying the parent or guardian's room, using existing bedding
DONE
Pets
Pets allowed (dogs only, 1 total)*
Service animals welcome
Restrictions apply*
WIFI
Internet
Free WiFi in public areas
Free WiFi in rooms
LOCAL_PARKING
Parking
Free onsite self parking
Onsite RV/bus/truck parking (fees apply)
Wheelchair-accessible parking and van parking on site
DONE
Other information
Designated smoking areas
Property amenities
Food and drink
Free full breakfast each morning 6 AM–10 AM
Coffee/tea in a common area
Traveling with children
Children stay free (see details)
Services
24-hour front desk
Free newspapers in lobby
Facilities
Picnic area
Accessibility
Braille/raised signage
Wheelchair-accessible path of travel
Wheelchair-accessible parking
Assistive listening devices available
Wheelchair-accessible van parking
Room amenities
Be entertained
Flat-screen television
Cable TV channels
Home comfort
Air conditioning
Coffee/tea maker
Iron/ironing board
Sleep well
Alarm clock
Free crib/infant bed
Bed sheets provided
Freshen up
Free toiletries
Hair dryer
Towels
Stay connected
Free weekday newspapers
Free WiFi
Free local calls
Food and drink
Refrigerator
Microwave
More
Daily housekeeping
Fees & policies
Pets
Service animals exempt from fees
Pet deposit: USD 20 per stay
Pets are allowed for an extra charge of USD 15 per pet, per night, plus a one-time cleaning fee of USD 25
Policies
This property does not have elevators.
Guests can rest easy knowing there's a carbon monoxide detector, a fire extinguisher, a smoke detector, and a first aid kit on site.
This property accepts credit cards. Cash is not accepted.
Credit cards accepted: Visa, Mastercard, American Express, Discover, Diners Club, JCB International, Carte Blanche
This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Choice).
Also known as
Quality Cairo
Quality Inn Cairo
Quality Inn Cairo I-57 Hotel
Quality Inn Cairo I-57 Cairo
Quality Inn Cairo I-57 Hotel Cairo
Quality Cairo I-57
Hotel Quality Inn Cairo I-57 Cairo
Cairo Quality Inn Cairo I-57 Hotel
Hotel Quality Inn Cairo I-57
Quality Inn Cairo I-57 Cairo
Quality Inn
Frequently asked questions
Does Quality Inn Cairo I-57 offer free cancellation for a full refund?
Yes, Quality Inn Cairo I-57 does have fully refundable room rates available to book on our site. If you’ve booked a fully refundable room rate, this can be cancelled up to a few days before check-in depending on the property's cancellation policy. Just make sure to check this property's cancellation policy for the exact terms and conditions.
Are pets allowed at Quality Inn Cairo I-57?
Yes, dogs are welcome, with a limit of 1 total. There's a charge of USD 15 per pet, per night, and there's also a deposit of USD 20 per stay. Service animals are exempt from fees. Some restrictions may apply, so please contact the property for more details.
Is parking offered on site at Quality Inn Cairo I-57?
Yes, there's free self parking. RV/bus/truck parking is available.
What are the check-in and check-out times at Quality Inn Cairo I-57?
Check-in start time: 3 PM; Check-in end time: 3:30 AM. Check-out time is 11 AM.
What is there to do at Quality Inn Cairo I-57 and nearby?
Quality Inn Cairo I-57 has a picnic area.
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Reviews
Reviews
6.4
Good
All reviews shown are from real guest experiences. Only travelers who have booked a stay with us can submit a review. We verify reviews according to our guidelines and publish all reviews, positive or negative.More informationOpens in a new window
6.8
Cleanliness
5.8
Location
7.6
Staff & service
6.0
Property conditions & facilities
Popular mentions
Room
Bathroom
Service staff
Breakfast
Vat
Shower
Building
Coffee
Bed
Weather
Reviews
Verified
8/10 Very good
Oct 27, 2023
Friendly staff
Muriel
Muriel, 1-night trip
Verified
10/10 Exceptional
Aug 2, 2024
The room was very clean and the breakfast was pretty good. No complaints
Rhonda
Rhonda, 1-night trip
Verified
6/10 Good
Nov 3, 2024
Rooms were clean and without pests. The staff was nice. It has a quiet little seating area with a grill. The location is the setback. Cairo is an abandoned town with almost any restaurants, etc
Joe
Joe, 9-night trip
Verified
2/10 Poor
Sep 11, 2025
The staff in the office were the best part of our stay. However, the area around the hotel was run down, abandoned buildings everywhere, and the road to get to the hotel was full of potholes, borken glass everywhere, and the hotel itself looked to be the only building within it's vicinity that was in working condition. Neither my husband nor I slept. I asked for a refund so we could go to a safer location, but I didnt purchase the travel insurance. I would NOT recommend!
Hannah
Hannah, 1-night trip
Verified
8/10 Very good
Apr 18, 2024
There are very few places to stay in Cairo. The Quality Inn is pretty good considering that the town is not in good shape. The room was large, quiet and clean but aging. The receptionists were very friendly and helpful. The property is convenient for a visit to Fort Defiance. We were satisfied with this stay.
Cheryl
Cheryl, 1-night trip
Verified
8/10 Very good
May 8, 2024
Quick graduation trip
Good bang for your buck! Price through the app was on point and $25 less than going through the hotel..Room was clean zero complaints on cleanliness except for the carpet that you could feel moisture in which also made the hallway and rooms smell..Get rid of the carpet and put down laminate and I’m pretty sure the smell would go away!
Erica
Erica, 1-night trip
Verified
8/10 Very good
Apr 14, 2024
Much better than average breakfast, scrambled eggs, sausage gravy & waffles, in addition to usual. Very rundown neighborhood. Pile of dirty laundry in hall.
Kathy
Kathy, 1-night trip
Verified
4/10 Fair
Dec 1, 2024
Never again
Outdated, but clean could have made up for that. The bed was comfortable. The tub was stained with what appeared to be grout and filth. There were also whitish drips all over the brown doorframes. The mirror was definitely cleaned with the previous tenant’s dirty towels. The coffee condiments were incomplete and hadn’t been replaced. And if all the above wasn’t enough, the place is in a true ghost town!
Anita L
Anita L, 1-night trip
Verified
8/10 Very good
Aug 11, 2023
I always like to stay off the beat and path. Generally speaking it’s quite a bit quieter and calmer. This hotel was older obviously. It had one of those old heat lamps in the bathroom from the 1970’s. Brought a blast from the past. It was very clean which is most important to me. It did have usb ports for charging. I have portable ones tha I always take not every place has them. It was quiet and comfortable. Not too much room sanitizer.
Lori
Lori, 1-night trip
Verified
4/10 Fair
Apr 4, 2026
Breakfast was sparse. This motel needs a complete overhaul.
Susan
Susan, 1-night trip
Verified
6/10 Good
Apr 5, 2026
Dirty microwave and coffee maker, missing bulb in bathroom, blown bulb above sink, hole in the wall where an outlet must have been, towels were clean but had a smell of being in storage. Very dated interior but functional. God enough to sleep for one evening.
Nicole
Nicole, 1-night trip
Verified
10/10 Exceptional
Feb 10, 2026
Amenities, microwave, refrigerator,iron and iron board,Shower soap options
Maurice
Maurice, 2-night trip
Verified
10/10 Exceptional
Sep 28, 2025
Break fast was excellent
Uma
Uma, 1-night trip
Verified
2/10 Poor
Feb 19, 2026
The room was somewhat clean, but that’s the best I can say. The door from outside to the hallway didn’t lock or even close all the way. No staff and the office closed 11pm-5am. Sketchy part of town. No eateries close by. I would not recommend. Didn’t feel safe but we were exhausted so we stayed.
Tammie
Tammie, 1-night trip
Verified
4/10 Fair
Dec 29, 2025
The quality was not what I expected for a "Quality Inn". It felt more light a Motel 6. I was not satisfied at all.
ReShena
ReShena, 1-night trip
Verified
10/10 Exceptional
Aug 6, 2025
The checkin was fast and easy. The room is big and comfortable.
Karen
Karen, 1-night trip
Verified
10/10 Exceptional
Apr 12, 2025
We had a quiet and convenient one night stay.
Cindy
Cindy, 1-night trip
Verified
8/10 Very good
Apr 5, 2024
For the price, it was one of the best value's we have stayed at.
Johnny
Johnny, 1-night trip
Verified
10/10 Exceptional
Mar 18, 2024
Great breakfast, coffee in room, walk to Wall carpeting.
raymond
raymond, 1-night trip
Verified
10/10 Exceptional
Jun 8, 2025
Stay here almost weekly. Very quiet, not around anything other than a dollar general which is good. Just a bit pricey for a night.
Jeremy
Jeremy, 1-night trip
Verified
2/10 Poor
Feb 23, 2026
There was a dirty comb in the floor, the base of the toilet was crusted with urine, and the hair dryer didn’t work and was in pieces. I went to the office at 6 am to complain and show them pictures and it was locked up and all the lights were out. I am disabled and use a wheelchair and have to sit in the tub to bathe. If the toilet was crusted with urine, how can I be assured the tub was cleaned and sanitized? I would appreciate my money back and that was my intent when I went to the office but I was on a schedule and could not wait for them to get up and open.
Brandy
Brandy, 1-night trip
Verified
2/10 Poor
Jul 15, 2025
The hotel is in need of some serious upkeep and cleaning. It is in fairly poor condition, but it the only hotel in town.
Timothy
Timothy, 3-night trip
Verified
8/10 Very good
Aug 21, 2023
It was somewhat difficult to locate but decent place to spend night.
Sharon
Sharon, 1-night trip
Verified
8/10 Very good
Jun 10, 2025
It was ok. We were just passing by
tania
tania, 1-night trip
Verified
2/10 Poor
Sep 27, 2025
Isolated property, no businesses nearby. Trash overflowing. Room was not necessarily dirty but was had pieces coming apart. Breakfast had week-expired items.