Hotels in Defiance

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Dates

November 2025

December 2025

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Where to stay in Defiance?

$85 total

includes taxes & fees

Nov 20 - Nov 21

$141 total

includes taxes & fees

Dec 12 - Dec 13

$105 total

includes taxes & fees

Nov 24 - Nov 25

$106 total

includes taxes & fees

Nov 20 - Nov 21

$98 total

includes taxes & fees

Nov 30 - Dec 1

$126 total

includes taxes & fees

Dec 2 - Dec 3

$112 total

includes taxes & fees

Nov 23 - Nov 24

$151 total

includes taxes & fees

Nov 23 - Nov 24

$115 total

includes taxes & fees

Dec 14 - Dec 15

$70 total

includes taxes & fees

Dec 8 - Dec 9

$58 total

includes taxes & fees

Dec 1 - Dec 2

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Go beyond your typical stay in Defiance

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Top landmarks in Defiance

Missouri wineries have some of the most superb wine we've ever tasted! We recommend sipping on some chambourcin while basking in the sunshine.

Chandler Hill Vineyards

Travelers might want a tour of Chandler Hill Vineyards, just one of the places to visit, and located 1.3 mi (2.1 km) from central Defiance.

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August A. Busch Memorial Conservation Area

If you like spending time outside, why not spend the afternoon at August A. Busch Memorial Conservation Area, a park located 30.2 mi (48.6 km) from the center of St. Louis.

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Check out reviews of Defiance hotels guests love

Drury Plaza Hotel St. Louis Creve Coeur

10/10 Excellent

"It was very comfortable and nice. Staff was super!"

Courtyard by Marriott St Louis Creve Coeur

10/10 Excellent

"Efficient check-in. Room was clean, neutral smell (clean but not fragranced), new furnishings, spacious bathroom and easy-to-use shower (no higher-education degree required to use the faucet). The ambiance of the whole room and the outdoor courtyard and parking area was upscale and clean. Very impressed! We travel often and I would rate this room as one of the most comfortable and clean rooms we've stayed in. Highly recommend."