Hotels in East Prairie

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Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,000 reviews)
Escape to this serene Sikeston hotel with both indoor and outdoor pools near restaurants and shopping. The fitness center, free breakfast, WiFi and parking enhance your stay, while the helpful staff ensures comfort just minutes from Central Park.
The price is $111
$128 total
includes taxes & fees
Aug 9 - Aug 10
Drury Inn & Suites Sikeston, MO

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (488 reviews)
Experience Sikeston from this hotel with free breakfast, WiFi, and parking. Take a morning dip in the indoor pool or hit the fitness center. Near Central Park and Sikeston Depot Museum, guests love the helpful staff and clean rooms.
The price is $85
$96 total
includes taxes & fees
Aug 23 - Aug 24
Holiday Inn Express & Suites Sikeston Southwest by IHG

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (422 reviews)
The price is $71
$79 total
includes taxes & fees
Aug 2 - Aug 3
The Riverstone Hotel Charleston-Sikeston

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very Good, (301 reviews)
Warm comfort awaits at this Sikeston hotel where the indoor pool invites morning swims. Just minutes from Central Park and Sikeston Depot Museum, enjoy free WiFi, parking, and a fitness center while helpful staff enhance your stay.
The price is $89
$102 total
includes taxes & fees
Aug 28 - Aug 29
Comfort Inn & Suites Sikeston I-55

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1,008 reviews)
Experience comfort at this Sikeston hotel, offering free breakfast and parking close to Central Park. The helpful staff welcomes guests to enjoy the indoor pool and fitness center. With easy access to Sikeston Depot Museum, you'll find everything needed for a convenient Missouri stay.
The price is $93
$106 total
includes taxes & fees
Aug 9 - Aug 10
Best Western Plus Sikeston I-55

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (651 reviews)
This Charleston motel offers complimentary WiFi, parking, and on-the-go breakfast daily. Located with convenient interstate access to Cape Girardeau, guests consistently praise the helpful staff. The comfortable accommodations provide a practical base for exploring southeastern Missouri.
The price is $60
$66 total
includes taxes & fees
Aug 2 - Aug 3
Super 8 by Wyndham Charleston/Sikeston East MO

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (597 reviews)
Dive into vacation mode at this welcoming hotel with an indoor pool and fitness center near Central Park. After enjoying the complimentary breakfast, explore Sikeston Depot Museum before returning to relax in modern rooms with free WiFi.
The price is $102
$115 total
includes taxes & fees
Aug 23 - Aug 24
Hampton Inn Sikeston

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (101 reviews)
Located in Sikeston, this hotel offers free breakfast, WiFi, and parking. Take a refreshing swim in the indoor pool or grab a bite at the restaurant. Nearby attractions include Central Park and Sikeston Depot Museum for local exploration.
The price is $110
$125 total
includes taxes & fees
Aug 9 - Aug 10
Fairfield Inn & Suites by Marriott Sikeston

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (106 reviews)
Active travelers will appreciate the health club at this comfortable Charleston motel. Free WiFi keeps you connected, while complimentary parking saves you money. Located within driving distance of Cape Girardeau Municipal Airport for easy regional access.
The price is $69
$77 total
includes taxes & fees
Aug 1 - Aug 2
Eagle Inn Charleston

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (805 reviews)
This peaceful hotel offers a complimentary continental breakfast, free WiFi, and convenient parking. Located near I-55 Exit 67, guests consistently praise the helpful staff and clean rooms that provide a quiet retreat after exploring local attractions.
The price is $72
$83 total
includes taxes & fees
Aug 2 - Aug 3
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,000 reviews)
Travelers rave about this serene retreat with helpful staff and clean rooms. Take advantage of free WiFi, parking, and on-the-go breakfast. Work out in the fitness center before exploring Central Park and Sikeston Depot Museum nearby.
The price is $68
$78 total
includes taxes & fees
Aug 17 - Aug 18
Days Inn and Suites by Wyndham Sikeston

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (18 reviews)
The price is $109
$123 total
includes taxes & fees
Aug 16 - Aug 17
TownePlace Suites by Marriott Sikeston

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (147 reviews)
This welcoming motel offers convenience with complimentary WiFi and parking, plus round-the-clock front desk assistance. Explore nearby Central Park and Sikeston Depot Museum before returning to your comfortable accommodations.
The price is $61
$73 total
includes taxes & fees
Jul 31 - Aug 1
Country Yard Inn and Suite

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very Good, (69 reviews)
Discover comfort at this Marston hotel, just off Interstate 55. Wake up to a complimentary full breakfast before exploring nearby attractions. Free WiFi and parking add value to your stay in this convenient Missouri location.
The price is $83
$95 total
includes taxes & fees
Jul 31 - Aug 1
Super 8 By Wyndham Marston

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (419 reviews)
Slip into this inviting Union City hotel just minutes from Discovery Park of America's interactive exhibits. After exploring nearby attractions, unwind in the refreshing indoor pool or maintain your routine in the 24-hour fitness center. Free breakfast, WiFi and parking enhance your value-packed stay.
The price is $79
$94 total
includes taxes & fees
Aug 23 - Aug 24
Sleep Inn at Discovery Park of America

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
7.0 out of 10, Good, (658 reviews)
Cozy lodging near Central Park and Sikeston Depot Museum with complimentary breakfast, WiFi, and parking. Just 29 minutes from Cape Girardeau Municipal Airport, this Super 8 offers comfortable accommodations for exploring the area.
The price is $63
$72 total
includes taxes & fees
Aug 9 - Aug 10
Super 8 by Wyndham Sikeston/Miner Area

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.2 out of 10, Very Good, (533 reviews)
This Quality Inn offers a seasonal outdoor pool, rejuvenating hot tub, and complimentary breakfast near County Market Place. With free WiFi, parking, and easy access to Reelfoot Shopping Center, travelers appreciate the attentive staff.
The price is $67
$80 total
includes taxes & fees
Aug 30 - Aug 31
Quality Inn Union City US 51

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (574 reviews)
Inviting comfort awaits at this Union City motel where complimentary continental breakfast starts your day. Located near County Market Place and Reelfoot Shopping Center, enjoy free WiFi and parking with attentive staff ready to assist you.
The price is $60
$71 total
includes taxes & fees
Jul 31 - Aug 1
Country Hearth Inn & Suites Union City

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (191 reviews)
Minutes from County Market Place, this hotel offers a welcoming indoor pool, fitness center, and free breakfast. Guests rave about the helpful staff, while free parking makes exploring easy. Reelfoot Shopping Center is nearby for retail therapy.
The price is $102
$121 total
includes taxes & fees
Aug 9 - Aug 10
Hampton Inn Union City

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (293 reviews)
Set off I-57 in Cairo, this welcoming hotel provides complimentary full breakfast and self parking. Explore nearby Fort Defiance State Park or take a short drive to Ballard Wildlife Management Area while enjoying free WiFi throughout your stay.
The price is $64
$72 total
includes taxes & fees
Aug 14 - Aug 15
Quality Inn Cairo I-57
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in East Prairie

Learn more about East Prairie

East Prairie is well-known for its attractions such as Big Oak Tree State Park and Mississippi River.

A tree-lined landscape with a river and fields.

Check out reviews of East Prairie hotels guests love

Frequently asked questions

What hotels do travelers like in East Prairie?
Can I book a refundable hotel in East Prairie?
If you need the flexibility to change your travel plans to East Prairie, most hotels provide refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in East Prairie be like during my trip?
July and August are typically the warmest months in East Prairie when the average temp is 77°F. January and February are the coldest months when the average temperature is 41°F. March and April are the months with the most rain.
Why should I book my East Prairie accommodation with Hotels.com?
There are lots of reasons to book your East Prairie trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.