Hotels in Santa Clara
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9.0 out of 10, Wonderful, (4708)
9.0/10
Wonderful
(4708)
The price is $122
$122
$135 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Plaza Paitilla Inn Hotel
Plaza Paitilla Inn Hotel3.5 star property
Punta Paitilla, 8.4 km from Santa Clara
9.4 out of 10, Exceptional, (2136)
9.4/10
Exceptional
(2136)
The price is $108
$108
$119 total
includes taxes & fees
Jan 16 - Jan 17, 2026
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City5.0 star property
Juan Diaz, 2.8 km from Santa Clara
9.6 out of 10, Exceptional, (644)
9.6/10
Exceptional
(644)
The price is $224
$224
$247 total
includes taxes & fees
Jan 25 - Jan 26, 2026
8.8 out of 10, Excellent, (1054)
8.8/10
Excellent
(1054)
The price is $84
$84
$93 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Radisson Hotel Panama Canal
Radisson Hotel Panama Canal4.5 star property
Amador, 13.9 km from Santa Clara
8.4 out of 10, Very Good, (1004)
8.4/10
Very Good
(1004)
The price is $82
$82
$90 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Riande Aeropuerto Hotel & Casino
Riande Aeropuerto Hotel & Casino4.0 star property
8.7 km from Santa Clara
8.6 out of 10, Excellent, (1847)
8.6/10
Excellent
(1847)
The price is $125
$125
$138 total
includes taxes & fees
Dec 26 - Dec 27
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott4.5 star property
Obarrio, 7.5 km from Santa Clara
8.8 out of 10, Excellent, (1001)
8.8/10
Excellent
(1001)
The price is $159
$159
$175 total
includes taxes & fees
Jan 3 - Jan 4, 2026
7.8 out of 10, Good, (667)
7.8/10
Good
(667)
The price is $152
$152
$167 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Hyatt Regency Panama City
Hyatt Regency Panama City4.5 star property
Campo Alegre, 8.4 km from Santa Clara
10.0 out of 10, Exceptional, (131)
10/10
Exceptional
(131)
The price is $157
$157
$172 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Panama House Bed & Breakfast
Panama House Bed & Breakfast2.5 star property
Bella Vista, 7.1 km from Santa Clara
9.0 out of 10, Wonderful, (185)
9.0/10
Wonderful
(185)
The price is $41
$41
$45 total
includes taxes & fees
Dec 28 - Dec 29
Megapolis Hotel Panamá
Megapolis Hotel Panamá4.5 star property
Punta Paitilla, 8.2 km from Santa Clara
8.4 out of 10, Very Good, (1305)
8.4/10
Very Good
(1305)
The price is $214
$214
$236 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Central Hotel Panama Casco Viejo
Central Hotel Panama Casco Viejo4.0 star property
San Felipe, 11.5 km from Santa Clara
9.2 out of 10, Wonderful, (1003)
9.2/10
Wonderful
(1003)
The price is $241
$241
$265 total
includes taxes & fees
Jan 11 - Jan 12, 2026
The Westin Playa Bonita Panama
The Westin Playa Bonita Panama5.0 star property
19.1 km from Santa Clara
8.0 out of 10, Very Good, (1000)
8.0/10
Very Good
(1000)
The price is $228
$228
$251 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Summit Rainforest & Golf Resort
Summit Rainforest & Golf Resort4.0 star property
17.8 km from Santa Clara
8.4 out of 10, Very Good, (1000)
8.4/10
Very Good
(1000)
The price is $72
$72
$79 total
includes taxes & fees
Dec 30 - Dec 31
Principe Hotel and Suites
Principe Hotel and Suites3.0 star property
El Cangrejo, 7.8 km from Santa Clara
9.0 out of 10, Wonderful, (1616)
9.0/10
Wonderful
(1616)
The price is $55
$55
$61 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Best Western Plus Panama Zen Hotel
Best Western Plus Panama Zen Hotel4.0 star property
El Cangrejo, 7.6 km from Santa Clara
9.0 out of 10, Wonderful, (987)
9.0/10
Wonderful
(987)
The price is $101
$101
$111 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Crowne Plaza Panama Airport by IHG
Crowne Plaza Panama Airport by IHG4.0 star property
10.2 km from Santa Clara
8.4 out of 10, Very Good, (2333)
8.4/10
Very Good
(2333)
The price is $110
$110
$121 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Waymore Hotel Spa & Casino
Waymore Hotel Spa & Casino4.0 star property
El Cangrejo, 8.3 km from Santa Clara
9.0 out of 10, Wonderful, (624)
9.0/10
Wonderful
(624)
The price is $66
$66
$98 total
includes taxes & fees
Dec 26 - Dec 27
Ramada Plaza by Wyndham Panama Punta Pacifica
Ramada Plaza by Wyndham Panama Punta Pacifica4.0 star property
San Francisco, 6.6 km from Santa Clara
9.6 out of 10, Exceptional, (1125)
9.6/10
Exceptional
(1125)
The price is $98
$98
$108 total
includes taxes & fees
Jan 2 - Jan 3, 2026
9.0 out of 10, Wonderful, (1001)
9.0/10
Wonderful
(1001)
The price is $309
$309
$340 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
When is the best time to visit Panama City?
When is the best time to visit Panama City?Our prices for hotels in Panama City are cheapest in January
When is the best time to visit Panama City?
When is the best time to visit Panama City?
Our prices for hotels in Panama City are cheapest in January
Price trends for hotels in Panama City
Pricing is based on two traveler single night rates
Currently viewing crowd sizes and weather for December.
Typical weather for Panama City
December
High crowds
High 29°C / low 24°C. Cloudy most days.
View properties in December 29°
December, High crowds, average high temperature 29 degrees Celsius, average low temperature 24 degrees Celsius. Cloudy most days.
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January, Moderate crowds, average high temperature 30 degrees Celsius, average low temperature 24 degrees Celsius. Sunny most days.
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30°
February, High crowds, average high temperature 30 degrees Celsius, average low temperature 24 degrees Celsius. Sunny most days.
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31°
March, High crowds, average high temperature 31 degrees Celsius, average low temperature 24 degrees Celsius. Sunny most days.
24°
31°
April, Low crowds, average high temperature 31 degrees Celsius, average low temperature 24 degrees Celsius. Sunny most days.
24°
30°
May, Low crowds, average high temperature 30 degrees Celsius, average low temperature 25 degrees Celsius. Rainy most days.
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29°
June, Low crowds, average high temperature 29 degrees Celsius, average low temperature 25 degrees Celsius. Rainy most days.
25°
29°
July, High crowds, average high temperature 29 degrees Celsius, average low temperature 24 degrees Celsius. Rainy most days.
24°
29°
August, Moderate crowds, average high temperature 29 degrees Celsius, average low temperature 24 degrees Celsius. Rainy most days.
24°
29°
September, Low crowds, average high temperature 29 degrees Celsius, average low temperature 24 degrees Celsius. Rainy most days.
24°
29°
October, Moderate crowds, average high temperature 29 degrees Celsius, average low temperature 24 degrees Celsius. Rainy most days.
24°
29°
November, Moderate crowds, average high temperature 29 degrees Celsius, average low temperature 24 degrees Celsius. Rainy most days.
24°
Monthly weather averages (˚C)
Check out reviews of Santa Clara hotels guests love
Novotel Panama City
10/10 Excellent
"The hotel was very nice and the staff was great."
Decapolis Hotel Panama City
10/10 Excellent
"Good"
Megapolis Hotel Panamá
10/10 Excellent
"Best hotel I ever stayed"
Plaza Paitilla Inn Hotel
10/10 Excellent
"I had a wonderful stay at this hotel and highly recommend it.
The location is excellent and very central, very close to the Jewish community, including a synagogue and Chabad.
Everything is within walking distance — a pleasant neighborhood with a park, supermarket, pharmacy, and a shopping mall.
The rooms were very clean and well maintained, with a lovely view.
The breakfast was full and generous, with a wide variety of options — nothing was missing.
The internet connection was strong and reliable.
The service was available 24/7, and the staff was helpful and professional.
I would definitely stay here again.
"
Dreams Playa Bonita Panama - All Inclusive
10/10 Excellent
"Beautiful and luxurious "
Principe Hotel and Suites
10/10 Excellent
"Clean rooms, courteous staff. The front desk team is awesome. 2nd time visiting, i'll definitely be back!"
Marriott Panama Hotel
10/10 Excellent
"Yes"
Waymore Hotel Spa & Casino
10/10 Excellent
"Very good"
Hotel Riu Plaza Panama
10/10 Excellent
"The Riu EXCEEDED all my expectations. The customer service is definitely a 10, the breakfast is definitely a 10!! I met the kindest server Katuschka…I loved her. She would come hope to be back soon. "
Find out more about Santa Clara