Top 10 Hotels in La Mesa in 2026 (from $43)

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Where to stay in La Mesa?

A room with a bed, a desk with a chair, a television, and a door.

A hotel room with a bed, a desk, a TV, and a kitchenette.

A small kitchenette with a microwave, coffee maker, and a toaster. There are two black bar stools and a TV mounted on the wall displaying movie recommendations.

A bathroom with a black toilet, a black sink, a shower curtain, and a window.

1. Tocumen Comfort Stay

24 de Diciembre

$45

$50 total

includes taxes & fees

Sep 29 - Sep 30

A room with two beds, a desk with chairs, a television, and a window with blinds.

A small kitchenette with a microwave, a coffee maker, and a refrigerator. There are two chairs and a sofa.

A compact kitchen with a microwave, two stools, a small refrigerator, and a flat-screen TV mounted on the wall.

A bathroom with a sink, toilet, and shower curtain.

2. B&B Lodgings

24 de Diciembre

$49

$54 total

includes taxes & fees

Sep 29 - Sep 30

A room with a bed, a desk with a computer, a TV, and a fan.

A room with a tiled floor, a flat-screen TV mounted on the wall, a small refrigerator, a microwave, and two bar stools.

A bathroom with a black toilet, a black bidet, a sink with a black basin, and a towel rack with folded towels.

A small, modern room with a kitchenette, a flat-screen TV mounted on the wall, and a herringbone-patterned wooden floor.

3. PLEASANT HOSTAL PANAMA

24 de Diciembre

$43

$48 total

includes taxes & fees

Oct 2 - Oct 3

A spacious lobby with a high ceiling, modern lighting fixtures, and a glass entrance leading to a lower level.

A modern bar area with a central island, bar stools, and a television mounted on the ceiling.

A modern restaurant with checkered flooring, wooden chairs, and large windows offering a view of greenery.

A swimming pool with a clear water surface, surrounded by a covered area with lounge chairs and a bar area.

4. Crowne Plaza Panama Airport by IHG

Tocumen Airport

$136

$156 total

includes taxes & fees

Oct 6 - Oct 7

A hotel room with two single beds, a small table with a chair, a TV mounted on the wall, and a marble-patterned headboard.

A two-story building with a sign reading "HOTEL EXPRESS INN".

A rectangular swimming pool with blue tiles and a brick border.

A modern interior with a staircase, a seating area with a bench and tables, and a counter with a sign reading "NISATO".

5. Express Inn Panama International Airport Hostel

Tocumen Airport

$50

$54 total

includes taxes & fees

Sep 30 - Oct 1

A bedroom with a large bed, a nightstand, a dresser, and decorative wall art.

A multi-level interior with a wooden staircase, decorative lighting, and a blue wall.

An outdoor dining area with two stone statues, string lights, and a covered seating area.

A cozy living room with a television, a lamp, and a sofa.

6. ORHO Hotel Boutique 15 Minutes from PTY Airport

Tocumen Airport

$102

$133 total

includes taxes & fees

Sep 29 - Sep 30

A modern living room with a sofa, a coffee table, a flat-screen TV, and a view of greenery through large windows.

A swimming pool with a wooden bridge, surrounded by palm trees and lounge chairs.

A playground with multiple slides and climbing structures.

A hotel room with two beds, a desk, a television, and an air conditioning unit.

7. Riande Aeropuerto Hotel & Casino

Tocumen Airport

$108

$119 total

includes taxes & fees

Sep 29 - Sep 30

A building with a sign reading 'Lilia House' and a decorative wall with a sign stating 'Cada Familia tiene una.'

A dining area with a table set for two, chairs, a TV mounted on the wall, a decorative plant, and a window with decorative bars.

8. Swette Love 10 Minutes From the Airport Tocumen

Las Mañanitas

$57

$74 total

includes taxes & fees

Oct 11 - Oct 12

A modern cabin with a sloped roof, surrounded by trees, and a gravel path leading to the entrance.

A modern kitchen with a built-in refrigerator, a coffee maker, and a dining area with a table and chairs.

A modern kitchen with a built-in stove, a sink, and a shelf with dishes and a potted plant.

A modern room with a bed, a small table, and a chair. There is a window with a view of trees and a hammock outside.

9. Tiny Cabin

Panamá

$134

$147 total

includes taxes & fees

Sep 30 - Oct 1

A buffet with various food items including fruits, juices, and cheeses.

A hotel reception area with a wooden reception desk, seating area with chairs and ottomans, and a large window providing natural light.

An aerial view of a rectangular swimming pool with two lounge chairs and a ladder.

A gym with treadmills, weight machines, and dumbbells.

10. Courtyard by Marriott Panama Metromall

San Antonio

$101

$111 total

includes taxes & fees

Oct 23 - Oct 24

A hotel entrance with a central water feature, seating areas, and potted plants.

An outdoor dining area with wicker chairs and tables, a bar with bottles, and a pool in the background.

A spacious lobby with a wooden ceiling, a central wooden table surrounded by potted plants, and a marble wall with a large window in the background.

The entrance of The Santa Maria with a covered walkway and a view of the interior.

11. The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Juan Diaz

$269

$296 total

includes taxes & fees

Oct 15 - Oct 16

A rooftop pool with a city view, lounge chairs, and a clear sky.

A modern lounge area with a bar, seating, and a large window offering a city view.

A modern gym with treadmills, weight machines, and exercise balls.

A modern kitchen with a marble countertop, a refrigerator, and a dining area with a table set for two.

12. Corporate Stays Arcadia | Executive Furnished Apartments

Costa del Este

$104

$167 total

includes taxes & fees

Oct 3 - Oct 4

A rooftop pool with a city view, modern architecture, and outdoor seating.

A modern hotel room with a large bed, a desk, and a view of the cityscape.

A high-rise building with a view of the ocean and a parking area with palm trees.

A narrow street with multi-story buildings, balconies, and a central building with a red roof.

13. The Westin Panama

Costa del Este

$206

$226 total

includes taxes & fees

Oct 10 - Oct 11

A swimming pool with lounge chairs, surrounded by greenery and tall buildings in the background.

A modern living room with a sofa, a dining table, and a staircase leading to an upper level.

A modern apartment with a kitchen, dining area, and living room.

A modern building with the sign 'DOVILLE' and 'CIRCUNVENTENARIO' indicating a hotel or similar establishment.

14. Apex Executive Apartments - Dovle

Parque Lefevre

$104

$201 total

includes taxes & fees

Oct 4 - Oct 5

A modern outdoor swimming pool with a clear view of a tall building in the background.

A modern urban pathway lined with lush greenery and a pool, leading to a building with balconies and a clear sky.

A modern reception area with a brick wall, wooden paneling, and a neon sign.

A modern kitchen with a curved island, bar stools, pendant lighting, and wooden shelving with plants.

15. Dovle Residences by HMS-Preferred Member

San Francisco

$155

$170 total

includes taxes & fees

Sep 29 - Sep 30

A swimming pool with lounge chairs, surrounded by greenery and modern buildings.

A modern interior with a staircase, a dining area, a living room, and a kitchen.

A modern building with a glass facade and balconies.

A modern living room with a sofa, coffee table, and a staircase.

16. Modern Apartment in Panama City 2BR Pool Gym

San Francisco

$127

$174 total

includes taxes & fees

Sep 29 - Sep 30

A modern living room with a sofa, a coffee table with flowers, a TV, and a large window with a city view.

A modern living room with a large window, a sofa, a coffee table, a TV on a wooden cabinet, and a dining table with chairs.

A dining area with a table set for four, large windows with a cityscape view, a small side table with a lamp, and a television on a stand.

A bedroom with a large bed, a view through a sliding door, and two framed pictures on the wall.

17. Boutique Apartments Panamá Coco del Mar

San Francisco

$47

$192 total

includes taxes & fees

Oct 1 - Oct 2

An elevator with a digital display showing the number 3, a sign above it reading 'PISO-3', and two safety signs on the wall.

A living room with a sectional sofa, a ceiling fan, a decorative wall piece, and a window with blinds.

A television mounted on a wall with a cityscape display, a small plant on a shelf, and a decorative light fixture.

A single bed with a dark blue mattress, a wooden headboard, and two pillows. There is a small wooden nightstand with drawers to the right of the bed. The room has plain white walls and a window with a sheer curtain.

18. Charming 3 Bedroom Apartment in San Miguelito, Panama City

José Domingo Espinar

$70

$98 total

includes taxes & fees

Oct 9 - Oct 10

A buffet with various food items and a decorative plant.

A spacious lobby with a high ceiling, a glass railing on the upper level, and a seating area with modern furniture.

A spa area with a hot tub, candles, and a curved bench.

A hotel with a swimming pool, outdoor seating, and a modern architectural design.

19. Sheraton Grand Panama

San Francisco

$185

$203 total

includes taxes & fees

Oct 4 - Oct 5

A modern hotel with a prominent entrance, multiple floors, and a well-lit facade.

A modern lounge area with seating, a bar, and a staircase.

A spacious lobby with a pool table, comfortable seating areas, and a bar with a variety of beverages.

A modern interior with two escalators leading to upper floors, a prominent 'a loft Panama' sign, and a staircase with glass railings.

20. Aloft by Marriott Panama

San Francisco

$132

$146 total

includes taxes & fees

Oct 4 - Oct 5

View all properties

Go beyond your typical stay in La Mesa

Check out reviews of La Mesa hotels guests love

Crowne Plaza Panama Airport by IHG

Tocumen Airport

10/10 Exceptional

Ceci

Riande Aeropuerto Hotel & Casino

Tocumen Airport

10/10 Exceptional

Roberto

ORHO Hotel Boutique 15 Minutes from PTY Airport

Tocumen Airport

10/10 Exceptional

sandro

A balcony with wicker chairs and a view of the cityscape.

A hotel room with a large bed, a desk with a lamp, a chair, and a view of a cityscape through a window.

A rooftop pool area with a view of high-rise buildings in the background.

A reception area with a marble wall, a 'Free Wireless Internet' sign, and a floral arrangement.

Ramada Plaza by Wyndham Panama Punta Pacifica

San Francisco

10/10 Exceptional

Theon

Courtyard by Marriott Panama Metromall

San Antonio

10/10 Exceptional

Carlos

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Juan Diaz

10/10 Exceptional

John

Corporate Stays Arcadia | Executive Furnished Apartments

Costa del Este

10/10 Exceptional

This place is even more beautiful than the pictures! We stayed in unit 1508 and it felt brand new—super clean, stylish, and in a very safe area. I was nervous about booking last minute, but check-in was smooth. Irving greeted us and made us feel at home. Another huge plus is the location—you’re right across the street from a beautiful, modern mall with tons of great stores, cafes, and restaurants. There’s also a dog park directly across the street, as well as a family-friendly park nearby...

Dinita

B&B Lodgings

24 de Diciembre

10/10 Exceptional

Ricardo

Sheraton Grand Panama

San Francisco

10/10 Exceptional

John

Aloft by Marriott Panama

San Francisco

10/10 Exceptional

Juan C Rey

San Francisco by Wynwood House

San Francisco

10/10 Exceptional

Jelani

The Westin Panama

Costa del Este

10/10 Exceptional

Alvaro

Boutique Apartments Panamá Coco del Mar

San Francisco

10/10 Exceptional

Spectacular view from the 31st floor of the city and partial ocean greeted us every morning, with a nice little patio to enjoy it from too. Three bedrooms, all with nice beds, plus a nice and large main and dining area. Everything worked well, including the air conditioning. Very safe residential building with front door security. It is not located in a main tourist area, but 5-10 min drive from best parts of Panama City. Area itself seemed safe. Food recommendation: one of the best restaurants...

Michael