Hotels in South San Francisco

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Aug 21 - Aug 22
Tomorrow
Aug 22 - Aug 23
This weekend
Aug 21 - Aug 23
Next weekend
Aug 28 - Aug 30

Where to stay in South San Francisco?

Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel
South San Francisco
$103
$120 total
includes taxes & fees
Sep 6 - Sep 7
Best Western Plus Grosvenor Airport Hotel

Home2 Suites by Hilton San Francisco Airport North

Home2 Suites by Hilton San Francisco Airport North
The East Side
$98
$115 total
includes taxes & fees
Sep 3 - Sep 4
Home2 Suites by Hilton San Francisco Airport North

DoubleTree by Hilton San Francisco South Airport Blvd

DoubleTree by Hilton San Francisco South Airport Blvd
South San Francisco
$130
$153 total
includes taxes & fees
Sep 4 - Sep 5
DoubleTree by Hilton San Francisco South Airport Blvd

Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point
The East Side
$147
$172 total
includes taxes & fees
Sep 6 - Sep 7
Embassy Suites by Hilton San Francisco Airport Oyster Point

Sonesta Select San Francisco Airport Oyster Point Waterfront

Sonesta Select San Francisco Airport Oyster Point Waterfront
Oyster Point
$105
$124 total
includes taxes & fees
Sep 6 - Sep 7
Sonesta Select San Francisco Airport Oyster Point Waterfront

Holiday Inn Express San Francisco-Airport North by IHG

Holiday Inn Express San Francisco-Airport North by IHG
South San Francisco
$94
$122 total
includes taxes & fees
Aug 23 - Aug 24
Holiday Inn Express San Francisco-Airport North by IHG

Hilton Garden Inn San Francisco Arpt North

Hilton Garden Inn San Francisco Arpt North
The East Side
$98
$115 total
includes taxes & fees
Sep 7 - Sep 8
Hilton Garden Inn San Francisco Arpt North

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Downtown South San Francisco
$127
$148 total
includes taxes & fees
Sep 1 - Sep 2
La Quinta Inn & Suites by Wyndham San Francisco Airport N

Four Points by Sheraton Hotel & Suites San Francisco Airport

Four Points by Sheraton Hotel & Suites San Francisco Airport
South San Francisco
$91
$107 total
includes taxes & fees
Sep 6 - Sep 7
Four Points by Sheraton Hotel & Suites San Francisco Airport

Hampton Inn San Francisco Airport

Hampton Inn San Francisco Airport
The East Side
$110
$130 total
includes taxes & fees
Sep 7 - Sep 8
Hampton Inn San Francisco Airport

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
Oyster Point
$152
$180 total
includes taxes & fees
Sep 4 - Sep 5
AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
Oyster Point
$123
$146 total
includes taxes & fees
Sep 1 - Sep 2
Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

Hotel Focus SFO

Hotel Focus SFO
The East Side
$96
$113 total
includes taxes & fees
Sep 20 - Sep 21
Hotel Focus SFO

Larkspur Landing Extended Stay Suites South San Francisco

Larkspur Landing Extended Stay Suites South San Francisco
The East Side
$127
$149 total
includes taxes & fees
Sep 5 - Sep 6
Larkspur Landing Extended Stay Suites South San Francisco

Travelodge by Wyndham San Francisco Airport North

Travelodge by Wyndham San Francisco Airport North
South San Francisco
$73
$87 total
includes taxes & fees
Aug 30 - Aug 31
Travelodge by Wyndham San Francisco Airport North

Hotel Nova SFO

Hotel Nova SFO
South San Francisco
$120
$140 total
includes taxes & fees
Aug 23 - Aug 24
Hotel Nova SFO

Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area

Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area
The East Side
$127
$148 total
includes taxes & fees
Sep 6 - Sep 7
Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area

Comfort Inn and Suites San Francisco Airport North

Comfort Inn and Suites San Francisco Airport North
The East Side
$101
$119 total
includes taxes & fees
Sep 6 - Sep 7
Comfort Inn and Suites San Francisco Airport North

Days Inn by Wyndham San Francisco S/Oyster Point Airport

Days Inn by Wyndham San Francisco S/Oyster Point Airport
Paradise Valley
$101
$126 total
includes taxes & fees
Aug 23 - Aug 24
Days Inn by Wyndham San Francisco S/Oyster Point Airport

Rodeway Inn South San Francisco Airport

Rodeway Inn South San Francisco Airport
South San Francisco
$100
$117 total
includes taxes & fees
Sep 11 - Sep 12
Rodeway Inn South San Francisco Airport
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Check out pet-friendly hotels in South San Francisco

Home2 Suites by Hilton San Francisco Airport North

Home2 Suites by Hilton San Francisco Airport North
The East Side
$98
$115 total
includes taxes & fees
Sep 3 - Sep 4
Home2 Suites by Hilton San Francisco Airport North

DoubleTree by Hilton San Francisco South Airport Blvd

DoubleTree by Hilton San Francisco South Airport Blvd
South San Francisco
$130
$153 total
includes taxes & fees
Sep 4 - Sep 5
DoubleTree by Hilton San Francisco South Airport Blvd

Sonesta Select San Francisco Airport Oyster Point Waterfront

Sonesta Select San Francisco Airport Oyster Point Waterfront
Oyster Point
$105
$124 total
includes taxes & fees
Sep 6 - Sep 7
Sonesta Select San Francisco Airport Oyster Point Waterfront

Hilton Garden Inn San Francisco Arpt North

Hilton Garden Inn San Francisco Arpt North
The East Side
$98
$115 total
includes taxes & fees
Sep 7 - Sep 8
Hilton Garden Inn San Francisco Arpt North

Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point
The East Side
$147
$172 total
includes taxes & fees
Sep 6 - Sep 7
Embassy Suites by Hilton San Francisco Airport Oyster Point

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Downtown South San Francisco
$127
$148 total
includes taxes & fees
Sep 1 - Sep 2
La Quinta Inn & Suites by Wyndham San Francisco Airport N

Four Points by Sheraton Hotel & Suites San Francisco Airport

Four Points by Sheraton Hotel & Suites San Francisco Airport
South San Francisco
$91
$107 total
includes taxes & fees
Sep 6 - Sep 7
Four Points by Sheraton Hotel & Suites San Francisco Airport

Hampton Inn San Francisco Airport

Hampton Inn San Francisco Airport
The East Side
$110
$130 total
includes taxes & fees
Sep 7 - Sep 8
Hampton Inn San Francisco Airport

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
Oyster Point
$123
$146 total
includes taxes & fees
Sep 1 - Sep 2
Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

Hotel Focus SFO

Hotel Focus SFO
The East Side
$96
$113 total
includes taxes & fees
Sep 20 - Sep 21
Hotel Focus SFO
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You may also like hotels with pools in South San Francisco

Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point
The East Side
$147
$172 total
includes taxes & fees
Sep 6 - Sep 7
Embassy Suites by Hilton San Francisco Airport Oyster Point

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
Oyster Point
$123
$146 total
includes taxes & fees
Sep 1 - Sep 2
Sonesta ES Suites San Francisco Airport Oyster Point Waterfront

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
Oyster Point
$152
$180 total
includes taxes & fees
Sep 4 - Sep 5
AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Downtown South San Francisco
$127
$148 total
includes taxes & fees
Sep 1 - Sep 2
La Quinta Inn & Suites by Wyndham San Francisco Airport N

Travelodge by Wyndham San Francisco Airport North

Travelodge by Wyndham San Francisco Airport North
South San Francisco
$73
$87 total
includes taxes & fees
Aug 30 - Aug 31
Travelodge by Wyndham San Francisco Airport North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Our prices for hotels in South San Francisco are cheapest in January
Price trends for hotels in South San Francisco
Pricing is based on two traveler single night rates
View properties in August
Typical weather for South San Francisco
August
High 20°C / low 14°C. Sunny most days.
View properties in August
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Monthly weather averages (˚C)

Top neighborhoods in South San Francisco

Downtown South San Francisco

Downtown South San Francisco buzzes with a blend of biotech innovation and cultural diversity. Corporate towers and colorful murals tell the story of this unique business hub. You'll find authentic taquerias, dim sum houses, and Filipino eateries nestled between modern office campuses along Grand Avenue. The neighborhood comes alive during weekdays when professionals fill its plazas and restaurants. Getting around is a breeze with nearby BART and Caltrain stations connecting you to San Francisco proper and beyond. Business hotels cater mostly to corporate travelers with practical amenities. The area quiets down after work hours, offering a genuine glimpse into Bay Area life away from tourist crowds.

Oyster Point

Oyster Point balances sleek biotech campuses with stunning San Francisco Bay views. The waterfront promenade offers perfect spots for watching waves crash against the shore or catching a beautiful sunset. Modern plazas feature public art installations while walking paths showcase both cutting-edge architecture and natural bay ecosystems. Business travelers appreciate the corporate hotels with meeting facilities and convenient access to office buildings. Dining options cater primarily to weekday lunch crowds, with most establishments closing early evening. The area is best explored by car, though waterfront paths provide scenic strolling opportunities away from the corporate hustle.

The East Side

The East Side delivers authentic local life away from San Francisco's tourist traps. Catch Bay views from San Bruno Point Park or explore diverse family-owned restaurants along Grand Avenue serving up killer tacos and pho. This residential neighborhood mixes Hispanic and Asian influences that shine through local markets and casual eateries. Budget travelers appreciate the affordable motels and extended-stay options that cost way less than downtown San Francisco. Buses connect to BART and Caltrain, though having wheels helps. Most spots close early, so plan your food adventures accordingly.

Paradise Valley

Paradise Valley offers a peaceful retreat from San Francisco's bustle while keeping you close to the action. This quiet residential neighborhood in South San Francisco balances suburban calm with convenient access to nearby attractions. Take a stroll through San Bruno Point Park or venture to local spots like K1 Speed for some indoor racing fun. Budget-friendly accommodations make Paradise Valley an appealing base for Bay Area exploration. The neighborhood's proximity to San Francisco International Airport and major highways ensures easy connections throughout the region. With ample street parking and minimal crowds, you'll appreciate this low-key alternative to the city's more hectic districts.

Top landmarks in South San Francisco

San Bruno Point Park

7.8/10 (451 reviews)
If you like quiet time surrounded by flowers and greenery, hang out at San Bruno Point Park in The East Side. Our travelers also like this walkable area for its restaurants. Want to stretch your legs some more? Head to Bayfront Park and John McLaren Park, both nearby.
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South San Francisco Convention Center

7.8/10 (668 reviews)
South San Francisco Convention Center is worth a visit, located 0.5 mi (0.8 km) from central South San Francisco. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander.
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San Francisco Baking Institute

7.6/10 (423 reviews)
If you'd like to get a taste of South San Francisco student life, check out San Francisco Baking Institute in The East Side. Let yourself be amazed at the art galleries in the area— your cultural tour starts here. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. South San Francisco has lots of other significant landmarks you might want to visit such as Golden Gate Bridge.
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See's Candies

8.0/10 (474 reviews)
See's Candies is 1.2 mi (2 km) from central South San Francisco, why not stop by during your stay. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. If you have fun at See's Candies, you'll love K1 Speed San Francisco and Coastside Comics, both located nearby.
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South San Francisco Hillside Sign

If you're planning a bit of sightseeing head to South San Francisco Hillside Sign— just one of the monuments in Paradise Valley. South San Francisco has lots of other popular landmarks you might want to see such as Golden Gate Bridge.
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K1 Speed San Francisco

7.6/10 (330 reviews)
K1 Speed San Francisco is 1.1 mi (1.7 km) from central South San Francisco, why not stop by during your stay. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. If you have fun at K1 Speed San Francisco, you'll love See's Candies and Coastside Comics, both located nearby.
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Sign Hill Park

If you like quiet time surrounded by flowers and greenery, then make a stop at Sign Hill Park located 8.6 mi (13.8 km) from the center of San Francisco. Want to stretch your legs some more? Head to San Bruno Point Park and John McLaren Park, both nearby.
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Learn more about South San Francisco

Look beyond the iconic 'South San Francisco The Industrial City' sign crowning Sign Hill Park for a city with its own distinct identity. Grand Avenue serves up a global feast of family-run eateries where locals debate the merits of each dumpling house. San Bruno Mountain offers hiking trails with sweeping Bay views that explain why residents tolerate the fog. See's Candies factory tours satisfy sweet tooths, while K1 Speed delivers indoor racing thrills. The Convention Center hosts events that draw visitors who are surprised to discover this isn't simply San Francisco's southern neighborhood. Despite tripling in population since World War II, 'South City' maintains its working-class roots while embracing its role as a Peninsula destination in its own right.

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A large, modern bridge with a unique design against a clear blue sky.
Photo by Tonette Pineda✈⛵🚌🚉🚃🚅🚀

Check out reviews of South San Francisco hotels guests love

Hyatt Regency San Francisco

Hyatt Regency San Francisco

8/10 Good
"The restaurant staff are of a quality not befitting a hotel of this class. The waiters do not pay the necessary attention to the customers. A busboy picked up a napkin that a previous customer had dropped on the floor, folded it, and placed it next to my plate."
Mehmet 3-night trip
Posted 4 hours ago
Hyatt Regency San Francisco
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

10/10 Excellent
"We enjoyed everything about this hotel, the close proximity to Pier 39 was great. The breakfast was delicious with many choices. Staff was helpful and friendly."
Kerry 3-night trip
Posted 9 hours ago
Hotel Riu Plaza Fisherman's Wharf
Hotel Focus SFO

Hotel Focus SFO

10/10 Excellent
"Todo muy bien"
Anyello Dragoslago Valadez 4-night trip
Posted 10 hours ago
Hotel Focus SFO
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

10/10 Excellent
"Parking is convenient across the street $90 for 2 days (Embarcadero Center 1, 2, 3 and 4 options). Nice hotel, clean room, and great location."
Yee Yee 2-night trip
Posted 10 hours ago
Club Quarters Hotel in San Francisco

Frequently asked questions

What accommodations do travelers like in South San Francisco?
Can I book refundable accommodations in South San Francisco?
If you need the flexibility to change your travel plans to South San Francisco, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow down the results.
Where can I stay in South San Francisco if I want a vacation rental instead of a hotel?
If you're looking for a good alternative to a hotel, review our selection of 25 vacation homes. In addition, you can choose from 12 apartments.
What will the weather in South San Francisco be like during my visit?
The warmest months in South San Francisco are usually September and August with an average temp of 62°F. February and January are the chilliest months when the average temp is 53°F. The rainiest months are December and January.
Why should I book my South San Francisco accommodation with Hotels.com?
There are lots of reasons to book your South San Francisco trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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