Hotels in Seneca

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Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (73 reviews)
Tucked between Lake Hartwell and Lake Keowee, these charming cabins offer serene patios and well-equipped kitchenettes. Just minutes from outdoor recreation areas and Cross Creek Plantation Golf, with free parking and cozy climate control for year-round comfort.
The price is $93
$146 total
includes taxes & fees
Jun 17 - Jun 18
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123
2.5 star property
Downtown
8.0 out of 10, Very Good, (702 reviews)
Serene hotel within a 15-minute drive of Clemson University offers a seasonal outdoor pool, complimentary WiFi, parking, and breakfast. Toy Train Park and The Gauntlet attractions are nearby, with guests consistently praising the quiet atmosphere and attentive service.
The price is $85
$99 total
includes taxes & fees
Jun 14 - Jun 15
Quality Inn Seneca Clemson Area US-123

Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1,005 reviews)
Unwind at this lakeside retreat with a poolside bar and seasonal outdoor pool just minutes from Clemson University. The 24-hour fitness center and hot tub provide recreation options while the restaurant and lounge offer on-site dining convenience.
The price is $109
$135 total
includes taxes & fees
May 20 - May 21
Lakeside Lodge Clemson

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
3.0 star property
Seneca
9.4 out of 10, Exceptional, (230 reviews)
Minutes from Clemson University and Lakes Keowee and Hartwell, this Seneca hotel offers free breakfast and parking. Refresh at the outdoor pool or fitness center after exploring nearby Golden Corner Plaza and Gignilliat Community Center.
The price is $129
$142 total
includes taxes & fees
May 31 - Jun 1
Fairfield Inn & Suites Seneca Clemson Univ Area

Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
Seneca
8.4 out of 10, Very Good, (659 reviews)
Located within a 10-minute drive of Clemson University, this Seneca hotel offers a seasonal outdoor pool and free daily breakfast. Guests appreciate the helpful staff and clean rooms, while enjoying convenient access to local attractions.
The price is $98
$108 total
includes taxes & fees
May 24 - May 25
Best Western Seneca-Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
2.0 star property
Seneca
6.8 out of 10, (749 reviews)
This Seneca motel offers easy access to Clemson University and Lake Keowee. Take a refreshing dip in the seasonal outdoor pool after exploring nearby Lake Hartwell. Free WiFi, parking, and daily on-the-go breakfast add exceptional value.
The price is $73
$80 total
includes taxes & fees
Jun 17 - Jun 18
Days Inn by Wyndham Seneca / Clemson Area

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (840 reviews)
This convenient Seneca hotel offers a complimentary morning meal, fitness center, and free parking just 5 minutes from campus. Guests praise the attentive staff, while Littlejohn Coliseum and Sloan Tennis Center are located nearby.
The price is $112
$124 total
includes taxes & fees
Jun 18 - Jun 19
Tru by Hilton Seneca Clemson

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
2.5 star property
Seneca
9.2 out of 10, Wonderful, (711 reviews)
Just 5 minutes from Lake Keowee, this hotel offers a 24-hour fitness center and seasonal outdoor swimming. Enjoy complimentary breakfast, WiFi, and parking while staying close to Clemson University. Guests consistently praise the helpful staff and clean accommodations.
The price is $122
$134 total
includes taxes & fees
Jun 7 - Jun 8
Hampton Inn & Suites Seneca-Clemson Area

Baymont by Wyndham Easley/Greenville

Baymont by Wyndham Easley/Greenville
2.5 star property
Easley
7.4 out of 10, Good, (823 reviews)
The price is $78
$87 total
includes taxes & fees
May 25 - May 26
Baymont by Wyndham Easley/Greenville

Quality Inn & Suites Easley - Greenville

Quality Inn & Suites Easley - Greenville
2.5 star property
Easley
7.0 out of 10, Good, (445 reviews)
Wake up to a delicious continental breakfast at this Easley hotel. Jump into the seasonal outdoor pool after exploring nearby attractions. Free WiFi and parking make your stay hassle-free, with The Peace Center just a 15-minute drive away.
The price is $64
$71 total
includes taxes & fees
May 21 - May 22
Quality Inn & Suites Easley - Greenville

Days Inn by Wyndham Easley/Greenville/Clemson Area

Days Inn by Wyndham Easley/Greenville/Clemson Area
2.0 star property
Easley
6.2 out of 10, (852 reviews)
Escape to this welcoming Days Inn where a seasonal outdoor pool refreshes after exploring nearby trails. Located close to Easley Recreation Center and Dollar Tree Plaza, the motel offers free breakfast, WiFi, and parking. Guests consistently praise the helpful staff and clean accommodations.
The price is $63
$70 total
includes taxes & fees
May 23 - May 24
Days Inn by Wyndham Easley/Greenville/Clemson Area

Hampton Inn Anderson/ Alliance Business Park

Hampton Inn Anderson/ Alliance Business Park
2.5 star property
Anderson
9.2 out of 10, Wonderful, (839 reviews)
Start your day with a free breakfast before exploring nearby Anderson Motor Speedway. This hotel offers a seasonal outdoor pool, 24-hour fitness center, and complimentary WiFi and parking. The friendly staff ensures a comfortable, clean stay.
The price is $114
$126 total
includes taxes & fees
May 31 - Jun 1
Hampton Inn Anderson/ Alliance Business Park

Holiday Inn Express Anderson by IHG

Holiday Inn Express Anderson by IHG
2.5 star property
Anderson
8.4 out of 10, Very Good, (395 reviews)
This quiet hotel offers a rejuvenating retreat with its outdoor pool and fitness center. Located near Anderson Motor Speedway and Saluda Valley Golf Course, the property includes free breakfast, WiFi, and parking. Business travelers appreciate the helpful staff and convenient amenities.
The price is $110
$122 total
includes taxes & fees
Jun 19 - Jun 20
Holiday Inn Express Anderson by IHG

The Bleckley Inn

The Bleckley Inn
3.5 star property
Anderson
9.8 out of 10, Exceptional, (415 reviews)
Escape to this charming hotel featuring Restaurant 151's southern dishes and a fitness center for your workout needs. The rooftop terrace offers relaxing views while free parking adds convenience for exploring nearby Church Street Heritage Park.
The price is $210
$233 total
includes taxes & fees
May 21 - May 22
The Bleckley Inn

Home2 Suites by Hilton Anderson Downtown

Home2 Suites by Hilton Anderson Downtown
3.0 star property
Anderson
9.4 out of 10, Exceptional, (242 reviews)
This welcoming Anderson hotel offers a seasonal outdoor pool and fitness center, all within a short drive of Lake Hartwell. Nearby attractions include Church Street Heritage Park and Generator Park. Guests appreciate the attentive staff, complimentary WiFi, and morning breakfast.
The price is $140
$155 total
includes taxes & fees
May 31 - Jun 1
Home2 Suites by Hilton Anderson Downtown

Carolina Inn Anderson Clemson Area

Carolina Inn Anderson Clemson Area
2.5 star property
Anderson
10.0 out of 10, Exceptional, (2 reviews)
The price is $55
$61 total
includes taxes & fees
May 20 - May 21
Carolina Inn Anderson Clemson Area

Horizon Inn & Suites

Horizon Inn & Suites
2.0 star property
Anderson
4.6 out of 10, (312 reviews)
Unwind at this cozy hotel near Anderson Mall and North Anderson Park. Take advantage of the on-site fitness center after exploring local attractions. Free WiFi and complimentary parking make your stay in Anderson even more convenient.
The price is $54
$64 total
includes taxes & fees
May 20 - May 21
Horizon Inn & Suites

Super 8 by Wyndham Anderson/Clemson Area

Super 8 by Wyndham Anderson/Clemson Area
2.5 star property
Anderson
6.6 out of 10, (287 reviews)
Rise to complimentary on-the-go breakfast at this convenient Anderson hotel, just minutes from Lake Hartwell. Enjoy free WiFi and parking while staying near Anderson Mall and the Sports Center. Clemson Station is a short 22-minute drive away.
The price is $75
$83 total
includes taxes & fees
May 20 - May 21
Super 8 by Wyndham Anderson/Clemson Area

Quality Inn Clemson near University

Quality Inn Clemson near University
2.5 star property
Anderson
7.0 out of 10, Good, (923 reviews)
Minutes from Anderson Civic Center and Mall, this hotel offers a refreshing seasonal outdoor pool and garden terrace. Enjoy complimentary continental breakfast, WiFi, and parking during your stay. Helpful staff ensure a pleasant experience in the entertainment district.
The price is $57
$63 total
includes taxes & fees
Jun 8 - Jun 9
Quality Inn Clemson near University

Holiday Inn Anderson by IHG

Holiday Inn Anderson by IHG
3.0 star property
Anderson
8.8 out of 10, Excellent, (727 reviews)
Escape to a quiet retreat just 5 minutes from Lake Hartwell. This Anderson hotel offers an outdoor pool, restaurant, and bar for relaxation after exploring nearby attractions. Free WiFi and parking complement the helpful staff that guests consistently praise.
The price is $110
$122 total
includes taxes & fees
May 24 - May 25
Holiday Inn Anderson by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

When is the best time to visit Seneca?

Our prices for hotels in Seneca are cheapest in December
Price trends for hotels in Seneca
Pricing is based on two traveler single night rates
View properties in May
Currently viewing crowd sizes and weather for May.
Typical weather for Seneca
May
High 26°C / low 15°C. Sunny most days.
View properties in May
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May, no crowd data, average high temperature 26 degrees Celsius, average low temperature 15 degrees Celsius. Sunny most days.
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June, no crowd data, average high temperature 31 degrees Celsius, average low temperature 19 degrees Celsius. Sunny most days.
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July, no crowd data, average high temperature 32 degrees Celsius, average low temperature 21 degrees Celsius. Sunny most days.
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August, no crowd data, average high temperature 31 degrees Celsius, average low temperature 20 degrees Celsius. Sunny most days.
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September, no crowd data, average high temperature 28 degrees Celsius, average low temperature 18 degrees Celsius. Sunny most days.
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October, no crowd data, average high temperature 23 degrees Celsius, average low temperature 12 degrees Celsius. Sunny most days.
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November, no crowd data, average high temperature 17 degrees Celsius, average low temperature 6 degrees Celsius. Sunny most days.
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December, no crowd data, average high temperature 12 degrees Celsius, average low temperature 4 degrees Celsius. Sunny most days.
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January, no crowd data, average high temperature 10 degrees Celsius, average low temperature 1 degrees Celsius. Partly sunny.
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February, no crowd data, average high temperature 13 degrees Celsius, average low temperature 3 degrees Celsius. Partly sunny.
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March, no crowd data, average high temperature 17 degrees Celsius, average low temperature 6 degrees Celsius. Sunny most days.
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April, no crowd data, average high temperature 22 degrees Celsius, average low temperature 10 degrees Celsius. Sunny most days.
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Monthly weather averages (˚C)

Top neighborhoods in Seneca

Downtown

Downtown Seneca charms visitors with well-preserved historical buildings that tell the story of its railroad heritage. The tree-lined Ram Cat Alley showcases local history through colorful murals, while the old courthouse square hosts seasonal farmers markets and community events. You can explore the Bertha Lee Strickland Cultural Museum or browse antique shops filled with Southern treasures. Family-owned cafes serve up delicious Southern comfort food like fried green tomatoes and barbecue. Accommodations range from historic bed & breakfasts in Victorian homes to budget-friendly motels. The entire downtown is walkable with wide sidewalks, making it easy to discover this authentic slice of small-town America at your own pace.

Serenity Bay

Lake Keowee beckons from this peaceful coastal retreat nestled in Saxony Forest. Serenity Bay lives up to its name with tree-lined streets perfect for contemplative walks. Nearby Keowee Key Golf Course offers tee times for enthusiasts, while South Beach provides sandy relaxation without the crowds. The natural setting creates an ideal escape for bird watchers and nature photographers. Vacation rentals with weathered wood siding and muted earth tones blend seamlessly into the forest canopy. Getting around requires your own wheels since public transit is limited. The neighborhood trades bustling nightlife for cricket choruses and ocean breezes filtering through pine trees—exactly what makes this hidden gem worth finding.

Pine Ridge Point

Lake Keowee sparkles as the crown jewel of Pine Ridge Point, a peaceful residential haven in Seneca. Waterfront vacation homes nestle among tall pines, offering private docks and stunning views. Visitors spend days swimming in crystal-clear waters, boating across the lake, or simply unwinding on expansive decks beneath Carolina blue skies. This neighborhood is all about authentic lakeside living without commercial distractions. Most travelers cook in well-equipped rental kitchens or drive 15 minutes to Seneca for restaurants. Personal vehicles are essential for getting around, though scenic paths along the shoreline make for perfect evening strolls.

Indian Oaks

Indian Oaks gives you all the peaceful vibes of suburban life with none of the tourist chaos. This leafy neighborhood in Seneca lets you live like a local under a canopy of mature oak trees. The curved streets and manicured lawns create a park-like setting that's perfect for morning walks. Lake Keowee is just a short drive away when you need a water fix. You'll need wheels to get around since public transit is limited and restaurants aren't within walking distance. Most visitors stay in vacation rental homes with private yards and driveways. The neighborhood gets incredibly quiet after dark—ideal for travelers who want to experience authentic suburban living while having Seneca's attractions nearby.

Top landmarks in Seneca

Learn more about Seneca

Between the crystal waters of Lake Keowee and the misty cascade of Isaqueena Falls lies a playground for outdoor enthusiasts. Kayak across the lake while keeping an eye out for bald eagles soaring overhead and blue herons stalking the shallows. The lush forests of Oconee State Park offer hiking trails for every skill level, with shade-dappled paths winding through ancient trees. Twin Lakes Recreation Area provides family-friendly spots to picnic after a morning on the water. Dog owners shouldn't miss The Pier Dog Park, where four-legged friends can splash along the shoreline. After a day of adventure, the coffeehouses in the historic downtown offer the perfect place to recharge while planning tomorrow's excursion to Keowee Key Golf Course or Lake Hartwell.

Lake Keowee South Carolina

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Frequently asked questions

What accommodations do travelers like in Seneca?
Can I book refundable accommodations in Seneca?
If you want the flexibility to change your travel plans to Seneca, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Seneca if I want a budget-friendly accommodation?
Lakeside Lodge Clemson, Quality Inn Seneca Clemson Area US-123 and Tru by Hilton Seneca Clemson are a few accommodations you might want to consider that'll save you money.
Where can I stay in Seneca if I want a vacation rental instead of a hotel?
If you want to find a good alternative to a hotel, review our selection of 208 vacation homes. In addition, there are 20 apartments and 12 condos.
What will the weather in Seneca be like during my visit?
The warmest months in Seneca are usually July and August with an average temp of 76°F. January and February are the chilliest months when the average temp is 46°F. The rainiest months are December and January.
Why should I book my Seneca hotel with Hotels.com?
There are plenty of reasons to book your Seneca travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.