Hotels in Seneca

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Check prices for these dates

Tonight
Aug 24 - Aug 25
Tomorrow
Aug 25 - Aug 26
This weekend
Aug 28 - Aug 30
Next weekend
Sep 4 - Sep 6

Top 5 hotels in Seneca at a glance

  1. Quality Inn Seneca US-123 — 2.5-star hotel in Seneca. Guest rating: 8.0/10 — Very Good.
  2. Tru by Hilton Seneca Clemson — 2.5-star hotel in Seneca. Guest rating: 9.2/10 — Wonderful.
  3. Hampton Inn & Suites Seneca-Clemson Area — 2.5-star hotel in Seneca. Guest rating: 9.2/10 — Wonderful.
  4. Best Western Seneca-Clemson — 2.5-star hotel in Seneca. Guest rating: 8.4/10 — Very Good.
  5. Lakeside Lodge Clemson — 2.5-star hotel in Seneca. Guest rating: 9.0/10 — Wonderful.

Where to stay in Seneca?

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
$76
$89 total
includes taxes & fees
Sep 3 - Sep 4
Quality Inn Seneca US-123

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
$106
$116 total
includes taxes & fees
Sep 6 - Sep 7
Tru by Hilton Seneca Clemson

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
$122
$134 total
includes taxes & fees
Aug 30 - Aug 31
Hampton Inn & Suites Seneca-Clemson Area

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
$97
$107 total
includes taxes & fees
Aug 27 - Aug 28
Best Western Seneca-Clemson

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
$109
$135 total
includes taxes & fees
Aug 26 - Aug 27
Lakeside Lodge Clemson

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
$120
$132 total
includes taxes & fees
Aug 30 - Aug 31
Fairfield Inn & Suites Seneca Clemson Univ Area

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
$81
$89 total
includes taxes & fees
Aug 27 - Aug 28
Days Inn by Wyndham Seneca / Clemson Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
$93
$146 total
includes taxes & fees
Sep 23 - Sep 24
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
Clemson
$149
$165 total
includes taxes & fees
Sep 1 - Sep 2
Clemson University's James F. Martin Inn

Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area
Clemson
$106
$117 total
includes taxes & fees
Aug 31 - Sep 1
Hampton Inn Clemson-University Area

Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
Clemson
$101
$112 total
includes taxes & fees
Sep 24 - Sep 25
Comfort Inn & Suites Clemson - University Area

Inn @ Clemson

Inn @ Clemson
Clemson
$89
$99 total
includes taxes & fees
Aug 26 - Aug 27
Inn @ Clemson

Rodeway Inn & Suites Walhalla

Rodeway Inn & Suites Walhalla
Walhalla
$76
$85 total
includes taxes & fees
Sep 23 - Sep 24
Rodeway Inn & Suites Walhalla

The Abernathy of Clemson

The Abernathy of Clemson
Clemson
$169
$188 total
includes taxes & fees
Sep 7 - Sep 8
The Abernathy of Clemson

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
Clemson
$101
$112 total
includes taxes & fees
Aug 27 - Aug 28
Best Western Plus Clemson Hotel & Conference Center

Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
Clemson
$110
$122 total
includes taxes & fees
Aug 30 - Aug 31
Holiday Inn Express & Suites Clemson by IHG

Courtyard Marriott Clemson

Courtyard Marriott Clemson
Clemson
$118
$131 total
includes taxes & fees
Aug 31 - Sep 1
Courtyard Marriott Clemson

The Inn at Patrick Square

The Inn at Patrick Square
Clemson
$149
$165 total
includes taxes & fees
Aug 30 - Aug 31
The Inn at Patrick Square

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
$239
$265 total
includes taxes & fees
Aug 26 - Aug 27
The Shepherd Hotel Downtown Clemson

Clemson Memorabilia House

Clemson Memorabilia House
Clemson
$89
$238 total
includes taxes & fees
Aug 26 - Aug 27
Clemson Memorabilia House
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Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
$90
per night
$105 total
includes taxes & fees
Quality Inn Seneca US-123

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
$134
per night
$147 total
includes taxes & fees
Tru by Hilton Seneca Clemson

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
$114
per night
$125 total
includes taxes & fees
Best Western Seneca-Clemson

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
$134
per night
$147 total
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
$88
per night
$97 total
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
$109
per night
$135 total
includes taxes & fees
Lakeside Lodge Clemson

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
$139
per night
$153 total
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
$114
per night
$169 total
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
$114
per night
$251 total
includes taxes & fees
Tru by Hilton Seneca Clemson

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
$85
per night
$199 total
includes taxes & fees
Quality Inn Seneca US-123

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
$129
per night
$284 total
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
$110
per night
$241 total
includes taxes & fees
Best Western Seneca-Clemson

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
$149
per night
$328 total
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
$119
per night
$294 total
includes taxes & fees
Lakeside Lodge Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
$103
per night
$226 total
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
$209
per night
$548 total
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

6 Mi to South Cove Boat Ramp! Lake Keowee Escape

6 Mi to South Cove Boat Ramp! Lake Keowee Escape
Seneca
$258
per night
$799 total
includes taxes & fees
6 Mi to South Cove Boat Ramp! Lake Keowee Escape

Screened Patio & Yard: Clemson Weekends/lakes Stay

Screened Patio & Yard: Clemson Weekends/lakes Stay
Seneca
$206
per night
$756 total
includes taxes & fees
Screened Patio & Yard: Clemson Weekends/lakes Stay

Lake Keowee Gem! Close to Clemson & Hiking Trails

Lake Keowee Gem! Close to Clemson & Hiking Trails
Seneca
$627
per night
$1,641 total
includes taxes & fees
Lake Keowee Gem! Close to Clemson & Hiking Trails

Lakefront Seneca Vacation Rental w/ Shared Dock!

Lakefront Seneca Vacation Rental w/ Shared Dock!
Seneca
$395
per night
$1,071 total
includes taxes & fees
Lakefront Seneca Vacation Rental w/ Shared Dock!

Check out pet-friendly hotels in Seneca

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
$106
$116 total
includes taxes & fees
Sep 6 - Sep 7
Tru by Hilton Seneca Clemson

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
$76
$89 total
includes taxes & fees
Sep 3 - Sep 4
Quality Inn Seneca US-123

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
$109
$135 total
includes taxes & fees
Aug 26 - Aug 27
Lakeside Lodge Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
$81
$89 total
includes taxes & fees
Aug 27 - Aug 28
Days Inn by Wyndham Seneca / Clemson Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
$93
$146 total
includes taxes & fees
Sep 23 - Sep 24
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
View all properties

You may also like hotels with pools in Seneca

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
$109
$135 total
includes taxes & fees
Aug 26 - Aug 27
Lakeside Lodge Clemson

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
$97
$107 total
includes taxes & fees
Aug 27 - Aug 28
Best Western Seneca-Clemson

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
$122
$134 total
includes taxes & fees
Aug 30 - Aug 31
Hampton Inn & Suites Seneca-Clemson Area

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
$76
$89 total
includes taxes & fees
Sep 3 - Sep 4
Quality Inn Seneca US-123

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
$120
$132 total
includes taxes & fees
Aug 30 - Aug 31
Fairfield Inn & Suites Seneca Clemson Univ Area

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
$81
$89 total
includes taxes & fees
Aug 27 - Aug 28
Days Inn by Wyndham Seneca / Clemson Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Our prices for hotels in Seneca are cheapest in December
Price trends for hotels in Seneca
Pricing is based on two traveler single night rates
View properties in August
Typical weather for Seneca
August
High 31°C / low 20°C. Sunny most days.
View properties in August
31°
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18°
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12°
17°
12°
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22°
10°
26°
15°
31°
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Monthly weather averages (˚C)

Top neighborhoods in Seneca

Downtown

Downtown Seneca charms visitors with well-preserved historical buildings that tell the story of its railroad heritage. The tree-lined Ram Cat Alley showcases local history through colorful murals, while the old courthouse square hosts seasonal farmers markets and community events. You can explore the Bertha Lee Strickland Cultural Museum or browse antique shops filled with Southern treasures. Family-owned cafes serve up delicious Southern comfort food like fried green tomatoes and barbecue. Accommodations range from historic bed & breakfasts in Victorian homes to budget-friendly motels. The entire downtown is walkable with wide sidewalks, making it easy to discover this authentic slice of small-town America at your own pace.

Serenity Bay

Lake Keowee beckons from this peaceful coastal retreat nestled in Saxony Forest. Serenity Bay lives up to its name with tree-lined streets perfect for contemplative walks. Nearby Keowee Key Golf Course offers tee times for enthusiasts, while South Beach provides sandy relaxation without the crowds. The natural setting creates an ideal escape for bird watchers and nature photographers. Vacation rentals with weathered wood siding and muted earth tones blend seamlessly into the forest canopy. Getting around requires your own wheels since public transit is limited. The neighborhood trades bustling nightlife for cricket choruses and ocean breezes filtering through pine trees—exactly what makes this hidden gem worth finding.

Pine Ridge Point

Lake Keowee sparkles as the crown jewel of Pine Ridge Point, a peaceful residential haven in Seneca. Waterfront vacation homes nestle among tall pines, offering private docks and stunning views. Visitors spend days swimming in crystal-clear waters, boating across the lake, or simply unwinding on expansive decks beneath Carolina blue skies. This neighborhood is all about authentic lakeside living without commercial distractions. Most travelers cook in well-equipped rental kitchens or drive 15 minutes to Seneca for restaurants. Personal vehicles are essential for getting around, though scenic paths along the shoreline make for perfect evening strolls.

Indian Oaks

Indian Oaks gives you all the peaceful vibes of suburban life with none of the tourist chaos. This leafy neighborhood in Seneca lets you live like a local under a canopy of mature oak trees. The curved streets and manicured lawns create a park-like setting that's perfect for morning walks. Lake Keowee is just a short drive away when you need a water fix. You'll need wheels to get around since public transit is limited and restaurants aren't within walking distance. Most visitors stay in vacation rental homes with private yards and driveways. The neighborhood gets incredibly quiet after dark—ideal for travelers who want to experience authentic suburban living while having Seneca's attractions nearby.

Top landmarks in Seneca

A grassy field with yellow flowers and trees in the foreground, with mountains in the background.

Blue Ridge Field

Blue Ridge Field is worth a visit, located 0.8 mi (1.2 km) from central Seneca.
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A waterfall surrounded by autumn foliage.

High Falls County Park

High Falls County Park is worth a visit, located 7.8 mi (12.5 km) from central Seneca.
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Oconee County Library Seneca Branch

Oconee County Library Seneca Branch is worth a pic or two when discovering Downtown.
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South Cove Park

South Cove Park is worth a visit, located 2 mi (3.3 km) from central Seneca.
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Friendship Recreation Area

Friendship Recreation Area is worth a visit, located 6.5 mi (10.5 km) from central Seneca.
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Seneca City Hall

Seneca City Hall is worth a pic or two when discovering Downtown.
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Highpointe Lower Field

Highpointe Lower Field is worth a visit, located 5.7 mi (9.1 km) from central Seneca.
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The Gauntlet

If you want to see a show while you're in town, try and grab some tickets at The Gauntlet in Downtown. If you enjoy the show and want to see another, Oconee Community Theatre isn't far.
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Learn more about Seneca

Between the crystal waters of Lake Keowee and the misty cascade of Isaqueena Falls lies a playground for outdoor enthusiasts. Kayak across the lake while keeping an eye out for bald eagles soaring overhead and blue herons stalking the shallows. The lush forests of Oconee State Park offer hiking trails for every skill level, with shade-dappled paths winding through ancient trees. Twin Lakes Recreation Area provides family-friendly spots to picnic after a morning on the water. Dog owners shouldn't miss The Pier Dog Park, where four-legged friends can splash along the shoreline. After a day of adventure, the coffeehouses in the historic downtown offer the perfect place to recharge while planning tomorrow's excursion to Keowee Key Golf Course or Lake Hartwell.

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A calm lake with mountains in the background.

Check out reviews of Seneca hotels guests love

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"Me and my family had a great time"
Nirumol 1-night trip
Posted 5 days ago
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Quality Inn Seneca US-123

Quality Inn Seneca US-123

10/10 Excellent
"Persons at front desk and management"
Michael 1-night trip
Posted 7 days ago
Quality Inn Seneca US-123

Frequently asked questions

What accommodations do travelers like in Seneca?
Can I book refundable accommodations in Seneca?
If you want the flexibility to change your travel plans to Seneca, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Seneca if I want a budget-friendly accommodation?
Lakeside Lodge Clemson, Tru by Hilton Seneca Clemson and Quality Inn Seneca US-123 are a few accommodations you might want to consider that'll save you money.
Where can I stay in Seneca if I want a vacation rental instead of a hotel?
If you want to find a good alternative to a hotel, review our selection of 217 vacation homes. In addition, there are 21 apartments and 11 condos.
What will the weather in Seneca be like during my visit?
The warmest months in Seneca are usually July and August with an average temp of 76°F. January and February are the chilliest months when the average temp is 46°F. The rainiest months are December and January.
Why should I book my Seneca hotel with Hotels.com?
There are plenty of reasons to book your Seneca travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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