Hotels in Santa Cruz

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Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (371 reviews)
A sophisticated retreat in Santa Cruz featuring spa services with massages and facials. Two restaurants serving international cuisine complement the fitness center and hot tub. Near Patio Design LifeStyle Center and Ventura Mall with convenient airport access.
The price is $131
$131 total
May 29 - May 30
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Ibis Santa Cruz DE LA Sierra
Ibis Santa Cruz DE LA Sierra
3.0 star property
Santa Cruz
9.6 out of 10, Exceptional, (108 reviews)
Discover Santa Cruz from this modern hotel with a bar, café, and business-friendly amenities. Located near Municipal Library and Patio Design LifeStyle Center, enjoy free WiFi and parking while the helpful staff ensures a pleasant stay.
The price is $55
$55 total
May 2 - May 3
Ibis Santa Cruz DE LA Sierra
Camino Real Hotel
Camino Real Hotel
4.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (426 reviews)
Set in a prime Santa Cruz location, this luxurious hotel features indoor and outdoor pools, 2 bars, and a full-service spa offering massages. La Tranquera restaurant serves daily meals, with Ventura Mall and Santa Cruz Zoo nearby for exploration.
The price is $131
$131 total
May 30 - May 31
Camino Real Hotel
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (268 reviews)
Upscale retreat with a Roof Top Bar & Lounge serving three daily meals and stunning city views. Free breakfast, WiFi and parking complement the fitness center. Ventura Mall and Patio Design LifeStyle Center wait just minutes away.
The price is $94
$94 total
May 7 - May 8
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Marriott Santa Cruz de la Sierra Hotel
Marriott Santa Cruz de la Sierra Hotel
5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (230 reviews)
Set in Santa Cruz with international dining at Toborochi restaurant, this luxury hotel offers relaxing massages at the spa. Cool off in the outdoor pool, work out in the fitness center, or enjoy a drink at the bar after exploring nearby Ventura Mall.
The price is $127
$127 total
May 8 - May 9
Marriott Santa Cruz de la Sierra Hotel
Hotel LP Santa Cruz Centro
Hotel LP Santa Cruz Centro
3.0 star property
Santa Cruz
8.0 out of 10, Very Good, (285 reviews)
Located in the heart of Santa Cruz, this hotel offers convenient access to Ramon Tahuichi Aguilera Stadium and Blacutt Square. Enjoy a meal at the restaurant or relax with a drink at the bar after exploring. Free WiFi and parking enhance your stay.
The price is $49
$54 total
May 8 - May 9
Hotel LP Santa Cruz Centro
Hotel LP Equipetrol
Hotel LP Equipetrol
3.5 star property
Santa Cruz
8.2 out of 10, Very Good, (205 reviews)
Immerse yourself in Santa Cruz's vibrant energy at this modern hotel. Just minutes from Ventura Mall and Santa Cruz Zoo, enjoy convenient amenities including a pool, room service, and free WiFi for a seamless stay.
The price is $40
$45 total
May 29 - May 30
Hotel LP Equipetrol
TRYP by Wyndham Santa Cruz
TRYP by Wyndham Santa Cruz
4.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (160 reviews)
Immerse in Santa Cruz's vibrant scene at this Art Deco haven with a refreshing outdoor pool and relaxing sauna. Just minutes from Patio Design LifeStyle Center and the Zoo, enjoy complimentary breakfast, WiFi, and parking after a day of exploration.
The price is $99
$99 total
May 2 - May 3
TRYP by Wyndham Santa Cruz
Hotel Cortez
Hotel Cortez
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (136 reviews)
The price is $107
$107 total
May 8 - May 9
Hotel Cortez
Premium Suites Deluxe Aparthotel Equipetrol
Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (94 reviews)
The price is $39
$39 total
May 2 - May 3
Premium Suites Deluxe Aparthotel Equipetrol
Hotel G
Hotel G
3.5 star property
Santa Cruz
7.8 out of 10, Good, (106 reviews)
Central Santa Cruz location with free WiFi and parking, close to Las Brisas Shopping Center and the Zoo. This hotel provides a convenient base for exploring the area, with the airport just 24 minutes away and railway station nearby.
The price is $36
$36 total
May 30 - May 31
Hotel G
Cosmopolitano Hotel Boutique
Cosmopolitano Hotel Boutique
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (130 reviews)
Slip into vacation mode at this boutique retreat with an outdoor pool and poolside bar. Near Sacred Art Museum and Franco Aleman Cultural Center, the hotel offers free breakfast, WiFi, and parking. Massages add extra bliss after exploring the area.
The price is $71
$71 total
May 18 - May 19
Cosmopolitano Hotel Boutique
HOTEL OSHO
HOTEL OSHO
3.5 star property
Santa Cruz
9.4 out of 10, Exceptional, (49 reviews)
Immerse in serenity at this welcoming retreat featuring a full-service spa, outdoor pool, and hot tub. Just minutes from Santa Cruz's Contemporary Art Museum, enjoy complimentary breakfast and WiFi after exploring nearby cultural attractions.
The price is $57
$57 total
May 15 - May 16
HOTEL OSHO
Novotel Santa Cruz De La Sierra
Novotel Santa Cruz De La Sierra
5.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (111 reviews)
This luxurious Santa Cruz hotel offers both outdoor and children's pools plus a hot tub for relaxation. Kids stay entertained at the free club while adults unwind at the bar. Near Parque Ecológico with free breakfast, WiFi, and parking.
The price is $95
$95 total
May 24 - May 25
Novotel Santa Cruz De La Sierra
Delfines Collection Hotel By Mercure
Delfines Collection Hotel By Mercure
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (88 reviews)
Just steps from Ventura Mall and a short drive from the Santa Cruz Zoo, this welcoming hotel features free WiFi and room service. Daily housekeeping ensures a refreshing stay while the international airport is only 26 minutes away.
The price is $46
$46 total
May 8 - May 9
Delfines Collection Hotel By Mercure
Alfonsina Hotel Boutique by Inboccaluppo
Alfonsina Hotel Boutique by Inboccaluppo
3.5 star property
Santa Cruz
9.4 out of 10, Exceptional, (43 reviews)
Bask in the Bolivian sunshine at the outdoor pool before enjoying a cocktail at the bar. Minutes from Santa Cruz Zoo and free breakfast, parking, and WiFi elevate your stay at this fitness-equipped retreat.
The price is $80
$80 total
May 2 - May 3
Alfonsina Hotel Boutique by Inboccaluppo
Apart Hotel Toborochi
Apart Hotel Toborochi
3.0 star property
Santa Cruz
8.8 out of 10, Excellent, (60 reviews)
Escape to this refined Santa Cruz aparthotel where you'll enjoy an outdoor pool and onsite spa services. Every apartment includes a private balcony, fully equipped kitchen, and flat-screen TV. Municipal Library and Patio Design LifeStyle Center are located nearby.
The price is $135
$135 total
May 2 - May 3
Apart Hotel Toborochi
Yotau All Suites Hotel
Yotau All Suites Hotel
3.5 star property
Santa Cruz
7.0 out of 10, Good, (76 reviews)
The price is $113
$113 total
May 2 - May 3
Yotau All Suites Hotel
Swissôtel Santa Cruz De La Sierra
Swissôtel Santa Cruz De La Sierra
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (87 reviews)
Immerse yourself in this entertainment district gem near Ventura Mall. Unwind at the full-service spa, cool off in the outdoor pool with cocktails from the poolside bar, or dine at the restaurant after exploring Santa Cruz Zoo.
The price is $126
$126 total
May 15 - May 16
Swissôtel Santa Cruz De La Sierra
Chairú Eco Hotel
Chairú Eco Hotel
3.5 star property
Santa Cruz
9.4 out of 10, Exceptional, (62 reviews)
Immerse in eco-conscious luxury at this Santa Cruz retreat offering 2 on-site dining options and a relaxed bar/lounge. Explore nearby Ventura Mall and Patio Design LifeStyle Center, then unwind with complimentary WiFi and attentive 24-hour service.
The price is $56
$56 total
May 2 - May 3
Chairú Eco Hotel
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Check out family-friendly hotels in Santa Cruz

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

When is the best time to visit Santa Cruz?

Our prices for hotels in Santa Cruz are cheapest in February
Price trends for hotels in Santa Cruz
Pricing is based on two traveler single night rates
View properties in May
Currently viewing crowd sizes and weather for May.
Typical weather for Santa Cruz
May
High 25°C / low 18°C. Sunny most days.
View properties in May
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May, no crowd data, average high temperature 25 degrees Celsius, average low temperature 18 degrees Celsius. Sunny most days.
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June, no crowd data, average high temperature 24 degrees Celsius, average low temperature 17 degrees Celsius. Sunny most days.
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July, no crowd data, average high temperature 25 degrees Celsius, average low temperature 17 degrees Celsius. Sunny most days.
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August, no crowd data, average high temperature 28 degrees Celsius, average low temperature 18 degrees Celsius. Sunny most days.
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September, no crowd data, average high temperature 31 degrees Celsius, average low temperature 21 degrees Celsius. Sunny most days.
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October, no crowd data, average high temperature 32 degrees Celsius, average low temperature 22 degrees Celsius. Sunny most days.
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November, no crowd data, average high temperature 32 degrees Celsius, average low temperature 22 degrees Celsius. Sunny most days.
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December, no crowd data, average high temperature 31 degrees Celsius, average low temperature 22 degrees Celsius. Sunny most days.
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January, no crowd data, average high temperature 31 degrees Celsius, average low temperature 22 degrees Celsius. Sunny most days.
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February, no crowd data, average high temperature 29 degrees Celsius, average low temperature 22 degrees Celsius. Cloudy most days.
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March, no crowd data, average high temperature 29 degrees Celsius, average low temperature 21 degrees Celsius. Sunny most days.
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April, no crowd data, average high temperature 28 degrees Celsius, average low temperature 20 degrees Celsius. Sunny most days.
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Monthly weather averages (˚C)

Top neighborhoods in Santa Cruz

Top landmarks in Santa Cruz

Learn more about Santa Cruz

Santa Cruz is applauded for its cultural attractions such as Cine Center and Sacred Art Museum.

Check out reviews of Santa Cruz hotels guests love

Frequently asked questions

What hotels do travelers recommend in Santa Cruz?
Where can I find free parking at my hotel in Santa Cruz?
These hotels offer the perk of free parking: Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel, Hotel LP Equipetrol and Swissôtel Santa Cruz De La Sierra. There are 8 options you may want to check out on our site.
Can I book refundable hotels in Santa Cruz?
If you want the flexibility to change your plans to Santa Cruz, most accommodations offer refundable* rates you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.
Where can I stay in Santa Cruz if I want a vacation rental instead of a hotel?
If you want to find a good alternative to a hotel, browse our selection of 21 vacation homes. In addition, you can choose from 184 apartments.
What will the weather in Santa Cruz be like during my trip?
Santa Cruz is a great place to visit to enjoy the sunshine any time of year with an average temp of 70°F.
Why should I book my Santa Cruz accommodation with Hotels.com?
There are lots of reasons to book your Santa Cruz trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.