Hotels in St. Charles

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Where to stay in St. Charles?

Suite (Buffalo Bill Suite) | Living area | Flat-screen TV

Boat Whirlpool Suite | Desk, iron/ironing board (on request), WiFi (free)

1. Stone Mill Hotel & Suites

Lanesboro

$105

$113 total

includes taxes & fees

Sep 15 - Sep 16

In-room safe, desk, blackout drapes, iron/ironing board

2. Days Inn by Wyndham Winona

Winona

$68

$76 total

includes taxes & fees

Sep 20 - Sep 21

Studio Suite, 1 King Bed, Non Smoking | Desk, blackout drapes, iron/ironing board, cribs (free)

Suite, 1 King Bed, Non Smoking | Desk, blackout drapes, iron/ironing board, cribs (free)

Indoor pool, open 7:00 AM to midnight, sun loungers

3. AmericInn by Wyndham Winona

Winona

$118

$132 total

includes taxes & fees

Oct 11 - Oct 12

Apartment, 1 Bedroom, 2 Queen Beds, Non Smoking | Premium bedding, down comforters, pillowtop beds, desk

4. AmericInn by Wyndham Rochester Near Mayo Clinic

Rochester

$77

$89 total

includes taxes & fees

Sep 18 - Sep 19

Family Suite, Multiple Beds, Non Smoking, Private Bathroom | Blackout drapes, soundproofing, iron/ironing board (on request)

5. The Wen Inn formerly Andor Wenneson

Peterson

$113

$123 total

includes taxes & fees

Sep 15 - Sep 16

Suite, 1 King Bed, Jetted Tub | In-room safe, desk, laptop workspace, iron/ironing board

6. Holiday Inn Express Rochester South - Mayo Area by IHG

Rochester

$96

$111 total

includes taxes & fees

Sep 20 - Sep 21

Luxury Suite, 1 King Bed, Non Smoking, Hot Tub | Desk, iron/ironing board, cribs (free), rollaway beds (surcharge)

7. Express Suites Riverport Inn & Suites

Winona

$120

$134 total

includes taxes & fees

Sep 15 - Sep 16

8. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Rochester

$76

$87 total

includes taxes & fees

Sep 20 - Sep 21

Studio, 1 Queen Bed | Living area | 40-inch flat-screen TV with digital channels, TV

9. Spark by Hilton Rochester South

Rochester

$89

$103 total

includes taxes & fees

Sep 20 - Sep 21

Grand Double Room Single Use, 1 Bedroom, Kitchenette, River View | Soundproofing, iron/ironing board, rollaway beds (surcharge)

10. Green Gables Inn

Lanesboro

$108

$116 total

includes taxes & fees

Oct 4 - Oct 5

Indoor pool, open 9:00 AM to 10:00 PM, pool umbrellas, sun loungers

Executive Room, 2 Queen Beds, Refrigerator & Microwave, Pool View (Living Room) | Blackout drapes, soundproofing, iron/ironing board

Executive Room, 2 Queen Beds, Non Smoking, Refrigerator & Microwave (Living Room) | Blackout drapes, soundproofing, iron/ironing board

Standard Room, 2 Queen Beds, Accessible, Refrigerator & Microwave | Blackout drapes, soundproofing, iron/ironing board

11. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Rochester

$94

$108 total

includes taxes & fees

Sep 18 - Sep 19

In-room safe, laptop workspace, blackout drapes, iron/ironing board

12. Hampton Inn Rochester-South

Rochester

$106

$122 total

includes taxes & fees

Sep 20 - Sep 21

Desk, blackout drapes, iron/ironing board, cribs (free)

Indoor pool, open 7:00 AM to 11:00 PM, sun loungers

13. Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

$82

$95 total

includes taxes & fees

Oct 13 - Oct 14

14. Econo Lodge Mayo Clinic Area

Rochester

$70

$81 total

includes taxes & fees

Oct 4 - Oct 5

Room, 2 Queen Beds, Non Smoking (Pet-Friendly) | Desk, laptop workspace, blackout drapes, iron/ironing board (on request)

15. Super 8 by Wyndham Winona MN

Winona

$62

$70 total

includes taxes & fees

Sep 20 - Sep 21

Desk, laptop workspace, blackout drapes, iron/ironing board

16. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Kutzky Park

$101

$116 total

includes taxes & fees

Sep 18 - Sep 19

Egyptian cotton sheets, premium bedding, pillowtop beds, in-room safe

17. Home2 Suites by Hilton Rochester Mayo Clinic Area

Rochester

$122

$141 total

includes taxes & fees

Sep 25 - Sep 26

18. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park

$112

$128 total

includes taxes & fees

Sep 25 - Sep 26

Deluxe Double Room | Down comforters, pillowtop beds, blackout drapes, soundproofing

19. Country Trails Inn & Suites

Preston

$126

$140 total

includes taxes & fees

Sep 15 - Sep 16

Desk, laptop workspace, iron/ironing board, WiFi (free)

20. Med City Inn & Suites - Mayo Clinic Area

Kutzky Park

$71

$82 total

includes taxes & fees

Sep 15 - Sep 16

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Go beyond your typical stay in St. Charles

Pet friendly

Pool

Hot tub

Family friendly

Cottage

Learn more about St. Charles

St. Charles is well-known for its attractions such as Whitewater State Park and Whitewater River.

See all hotels in St. Charles

An aerial view of a town with industrial buildings, roads, and green areas.

Check out reviews of St. Charles hotels guests love

Holiday Inn Express Rochester South - Mayo Area by IHG

10/10 Excellent

"Clean big room, comfortable Bed and breakfast had a good selection."

The Berkman

10/10 Excellent

"Excellent service and wonderful room!"

EVEN Hotel Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"The night staff (Affinity) was super helpful to me checking in late. She was quite friendly and cool!"

Super 8 by Wyndham Winona MN

8/10 Good

"You get what you paid for. I went in with no expectations and it was worth it for my family during our 2 night stay, I booked my reservation very early so the price wasn’t ridiculously high. We just needed a place to sleep so we didn’t need anything fancy. Right when you walk in there is an odd smell but you don’t smell it in the room, a lot of their towels had stains so we had to ask a few times and their pillows are very flat. The plus is that it’s a walking distance to the bluff for hiking! Staffs were friendly and plenty of parking spots."

Hampton Inn Rochester-South

10/10 Excellent

"Hotel was very well maintained. Especially liked the fitness room and the Peleton exercise bike. Breakfast also exceeded my expectations. Will stay again."

AmericInn by Wyndham Rochester Near Mayo Clinic

8/10 Good

"The elevator needed vacuuming badly. The staff was helpful and friendly. Breakfast was good and convenient. Nice restaurant attached."

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

10/10 Excellent

"Waterslide was a hit for sure!!"

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent

"Staff was very helpful"

Express Suites Riverport Inn & Suites

8/10 Good

"Clean room. Friendly staff. Nice indoor pool. A bit pricey but not as bad as holiday inn."

Frequently asked questions

What accommodations do travelers recommend in St. Charles?

White Valley Motel is an accommodation that is popular with guests.

Can I book refundable accommodations in St. Charles?

If you need the flexibility to change your plans to St. Charles, most properties provide refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in St. Charles be like during my vacation?

July and August are typically the warmest months in St. Charles when the average temp is 67°F. January and February are the coldest months when the average temperature is 22°F. June and May are the months with the most rain.

Why should I book my St. Charles accommodation with Hotels.com?

There are plenty of reasons to book your St. Charles travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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