Hotels in Cairo

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Check prices for these dates

Tonight
Feb 25 - Feb 26
Tomorrow
Feb 26 - Feb 27
This weekend
Feb 27 - Mar 1
Next weekend
Mar 6 - Mar 8

Where to stay in Cairo?

Lobby
Quality Inn Cairo I-57
Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (282 reviews)
Set off I-57 in Cairo, this welcoming hotel provides complimentary full breakfast and self parking. Explore nearby Fort Defiance State Park or take a short drive to Ballard Wildlife Management Area while enjoying free WiFi throughout your stay.
The price is $68
$75 total
includes taxes & fees
Mar 6 - Mar 7
Quality Inn Cairo I-57
Exterior
The Riverstone Hotel Charleston-Sikeston
The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (408 reviews)
The price is $70
$78 total
includes taxes & fees
Feb 26 - Feb 27
The Riverstone Hotel Charleston-Sikeston
Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi
Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (624 reviews)
This Charleston motel offers complimentary WiFi, parking, and on-the-go breakfast daily. Located with convenient interstate access to Cape Girardeau, guests consistently praise the helpful staff. The comfortable accommodations provide a practical base for exploring southeastern Missouri.
The price is $62
$69 total
includes taxes & fees
Mar 3 - Mar 4
Super 8 by Wyndham Charleston/Sikeston East MO
Basic Double Room | Living area
La Center Motel
La Center Motel
2.0 star property
La Center
7.8 out of 10, Good, (17 reviews)
Escape to this relaxing La Center hotel with complimentary WiFi and parking. Just a 15-minute drive from Ohio River Valley and 16 minutes from Paducah Regional Airport, the convenient location makes exploring the area effortless.
The price is $60
$70 total
includes taxes & fees
Feb 26 - Feb 27
La Center Motel
Room, 1 King Bed, Non Smoking | View from room
Eagle Inn Charleston
Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (105 reviews)
Active travelers will appreciate the health club at this comfortable Charleston motel. Free WiFi keeps you connected, while complimentary parking saves you money. Located within driving distance of Cape Girardeau Municipal Airport for easy regional access.
The price is $64
$71 total
includes taxes & fees
Feb 26 - Feb 27
Eagle Inn Charleston
House (2 Bedrooms) | Interior
Quiet Country Stay: Modern Home Near Paducah
Quiet Country Stay: Modern Home Near Paducah
3.0 star property
Cunningham
The price is $121
$290 total
includes taxes & fees
Feb 26 - Feb 27
Quiet Country Stay: Modern Home Near Paducah
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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When is the best time to visit Cairo?

Our prices for hotels in Cairo are cheapest in March
Price trends for hotels in Cairo
Pricing is based on two traveler single night rates
View properties in February
Currently viewing crowd sizes and weather for February.
Typical weather for Cairo
February
High 8°C / low -1°C. Partly sunny.
View properties in February
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February, no crowd data, average high temperature 8 degrees Celsius, average low temperature -1 degrees Celsius. Partly sunny.
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March, no crowd data, average high temperature 14 degrees Celsius, average low temperature 5 degrees Celsius. Partly sunny.
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April, no crowd data, average high temperature 19 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
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May, no crowd data, average high temperature 25 degrees Celsius, average low temperature 15 degrees Celsius. Sunny most days.
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June, no crowd data, average high temperature 30 degrees Celsius, average low temperature 20 degrees Celsius. Sunny most days.
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July, no crowd data, average high temperature 32 degrees Celsius, average low temperature 21 degrees Celsius. Sunny most days.
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August, no crowd data, average high temperature 31 degrees Celsius, average low temperature 20 degrees Celsius. Sunny most days.
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September, no crowd data, average high temperature 28 degrees Celsius, average low temperature 17 degrees Celsius. Sunny most days.
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October, no crowd data, average high temperature 21 degrees Celsius, average low temperature 11 degrees Celsius. Sunny most days.
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November, no crowd data, average high temperature 14 degrees Celsius, average low temperature 5 degrees Celsius. Partly sunny.
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December, no crowd data, average high temperature 9 degrees Celsius, average low temperature 1 degrees Celsius. Partly sunny.
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January, no crowd data, average high temperature 6 degrees Celsius, average low temperature -2 degrees Celsius. Partly sunny.
-2°
Monthly weather averages (˚C)

Top landmarks in Cairo

Fort Defiance State Park

Stand at the exact spot where the mighty Mississippi and Ohio rivers collide in this historic park. Bring binoculars to spot wildlife while learning about Lewis and Clark's 1803 training ground.
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Learn more about Cairo

Cairo is well-known for its attractions such as Mississippi River and Ohio River Valley. The city has something for everyone including sights like Fort Defiance State Park within a small-town setting.

See all hotels in Cairo
Cairo Ohio River Bridge traversing over the Ohio River at sunset

Check out reviews of Cairo hotels guests love

Quality Inn Cairo I-57

Quality Inn Cairo I-57

10/10 Excellent
"Amenities, microwave, refrigerator,iron and iron board,Shower soap options "
Maurice 2-night trip
Posted 2 weeks ago
Quality Inn Cairo I-57

Frequently asked questions

What accommodations do travelers like in Cairo?
Quality Inn Cairo I-57 is a property that our guests really like.
Can I book refundable accommodations in Cairo?
If you're looking for the flexibility to change your travel plans to Cairo, most hotels offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
Where should I stay in Cairo if I'm looking for an affordable accommodation?
Quality Inn Cairo I-57 is an accommodation you might want to consider that'll save you money.
What will the weather in Cairo be like during my trip?
The warmest months in Cairo are usually July and August with an average temp of 76°F. January and February are the chilliest months when the average temp is 41°F. The rainiest months are April and March.
Why should I book my Cairo accommodation with Hotels.com?
There are plenty of reasons to book your Cairo travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.