I stayed with my family for three nights and we had a very pleasant experience.
The room was a very good size for 3 people, really quiet, with comfortable beds and a minibar with cold drinks at better prices than in the mini markets, basically, it had everything we needed to have a good rest after a strenuous day walking around Rome.
The hotel is extremely close to Vatican City and there is a metro station a few streets away, the area is safe to walk around even at night, and there are many restaurants with authentic Italian food and honest prices nearby.
The staff was very friendly and helpful, they waited for our late arrival, recommended places to eat, stored our luggage for a couple of hours after the check-out, and called a taxi for us.
Vatican Relais Rome was a great place to stay, I absolutely recommend it!